Potential Uses of Olive Oil Secoiridoids for the Prevention and Treatment of Cancer: A Narrative Review of Preclinical Studies

Emma, Maria Rita; Augello, Giuseppa; Stefano, Vita Di; Azzolina, Antonina; Giannitrapani, Lydia; Montalto, Giuseppe; Cervello, Melchiorre; Cusimano, Antonella

doi:10.3390/ijms22031234

Cited by 57 publications

(41 citation statements)

References 130 publications

(106 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the bitterness of many of this compounds has been considered to be a deterrent for herbivores [29]. The potential protective role exhibited by secoiridoids from Olea europaea L. for the prevention and treatment of cancers of inflammatory and reactive oxygen species (ROS)-mediated diseases was recently described in the literature [30,31]. Thus, the observed increase of secoiridoids content for the untreated infected cultivar could be also taken into account for possible biotechnological use in pharma industry.…”

Section: Cultivar-related Treatment Effects For Naturally Infected Leccino Cellina DI Nardò and Ogliarola Salentina Over The Two Leaf Sammentioning

confidence: 99%

Olive Cultivars Susceptible or Tolerant to Xylella fastidiosa Subsp. pauca Exhibit Mid-Term Different Metabolomes upon Natural Infection or a Curative Treatment

Girelli

Coco

Angilè

et al. 2021

Plants

View full text Add to dashboard Cite

Xylella fastidiosa subsp. pauca, is a bacterial phytopathogen associated with the “olive quick decline syndrome” (OQDS) causing severe economic losses to olive groves in Salento area (Apulia, Italy). In a previous work, we analyzed by 1H-NMR the metabolic pattern of naturally infected Ogliarola salentina and Cellina di Nardò susceptible cultivars untreated and treated with a zinc-copper citric acid biocomplex and we observed the treatment related variation of the disease biomarker quinic acid. In this study, we focused also on the Leccino cultivar, known to exhibit tolerance to the disease progression. The 1H-NMR-based metabolomic approach was applied with the aim to characterize the overall metabolism of tolerant Leccino in comparison with the susceptible cultivars Ogliarola salentina and Cellina di Nardò under periodic mid-term treatment. In particular, we studied the leaf extract molecular patterns of naturally infected trees untreated and treated with the biocomplex. The metabolic Leccino profiles were analyzed for the first time and compared with those exhibited by the susceptible Cellina di Nardò and Ogliarola salentina cultivars. The study highlighted a specificity in the metabolic response of the tolerant Leccino compared to susceptible cultivars. These differences provide useful information to describe the defensive mechanisms underlying the change of metabolites as a response to the infection, and the occurrence of different levels of disease, season and treatment effects for olive cultivars.

show abstract

Section: Cultivar-related Treatment Effects For Naturally Infected Leccino Cellina DI Nardò and Ogliarola Salentina Over The Two Leaf Sammentioning

confidence: 99%

Olive Cultivars Susceptible or Tolerant to Xylella fastidiosa Subsp. pauca Exhibit Mid-Term Different Metabolomes upon Natural Infection or a Curative Treatment

Girelli

Coco

Angilè

et al. 2021

Plants

View full text Add to dashboard Cite

show abstract

“…The anti-inflammatory effect of turmeric and extra virgin olive oil provoked interest in several scientific research and has been discovered to have antioxidant and anti-inflammatory properties and many other diet's health benefits. Each can alter the human immune system by influencing the release of interleukins involved in immunological defense [17,18,19].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Turmeric and Extra Virgin Olive Oil in the Management of IL 6 and IL 10 in Healthy Mice

Attiyah

Mohammed

2021

JPRI

View full text Add to dashboard Cite

Background: Anti-Inflammatory properties of turmeric and extra virgin olive oil have numerous health benefits. They exert and promote anti-inflammatory actions, moreover, each gives benefits that go beyond reducing inflammation. Objective: The aim of our study is to evaluate and compare the immunomodulatory effect of each turmeric and extra virgin olive oil (EVOO) alone or in combination. Methods: We demonstrated the serum level of pro-inflammatory cytokines IL-6 and IL-10 in healthy male Swiss albino mice (C57BL/6 strain) after oral intake of curcumin and extra virgin olive oil for six weeks by ELISA assay. Results: Our results showed that dietary intake of turmeric and EVOO had a reducing effect on serum IL-6 level and could increase the production of IL-10 level significantly. Inflammatory responses of turmeric and EVOO combination appear to be more effective on health by inhibition of IL 6 and induce IL 10 production. Conclusion: Anti-inflammatory effect of turmeric and EVOO can play an important role in modulating the level of IL 6 and IL-10. Moreover, co-administration of them having a greater anti-inflammatory effect.

show abstract

“…Oleuropein inhibited the cell growth and induced apoptosis in different cancer cell lines ( Emma et al, 2021 ). Oleuropein (125 mg/kg of diet), another potent polyphenol, has anticancer property.…”

Section: Methodology and Criteria Usedmentioning

confidence: 99%

Olive Oil: Nutritional Applications, Beneficial Health Aspects and its Prospective Application in Poultry Production

et al. 2021

View full text Add to dashboard Cite

Plant polyphenols have promoting health features, including anti-mutagenic, anti-inflammatory, anti-thrombotic, anti-atherogenic, and anti-allergic effects. These polyphenols improve the immune system by affecting the white blood cell proliferation, as well as by the synthesis of cytokines and other factors, which contribute to immunological resistance. Olive trees are one of the most famous trees in the world. Whereas, olive olive oil and derivatives represent a large group of feeding resource for farm animals. In recent years, remarkable studies have been carried out to show the possible use of olive oil and derivatives for improvement of both animal performance and product quality. In vivo application of olive oil and its derived products has shown to maintain oxidative balance owing to its polyphenolic content. Consumption of extra virgin olive oil reduces the inflammation, limits the risk of liver damage, and prevents the progression of steatohepatitis through its potent antioxidant activities. Also, the monounsaturated fatty acids content of olive oil (particularly oleic acid), might have positive impacts on lipid peroxidation and hepatic protection. Therefore, this review article aims to highlight the nutritional applications and beneficial health aspects of olive oil and its effect on poultry production.

show abstract

Potential Uses of Olive Oil Secoiridoids for the Prevention and Treatment of Cancer: A Narrative Review of Preclinical Studies

Cited by 57 publications

References 130 publications

Olive Cultivars Susceptible or Tolerant to Xylella fastidiosa Subsp. pauca Exhibit Mid-Term Different Metabolomes upon Natural Infection or a Curative Treatment

Olive Cultivars Susceptible or Tolerant to Xylella fastidiosa Subsp. pauca Exhibit Mid-Term Different Metabolomes upon Natural Infection or a Curative Treatment

Effectiveness of Turmeric and Extra Virgin Olive Oil in the Management of IL 6 and IL 10 in Healthy Mice

Olive Oil: Nutritional Applications, Beneficial Health Aspects and its Prospective Application in Poultry Production

Contact Info

Product

Resources

About