Potential Use of Iron Chelators against Oxidative Damage

Oxidative Stress, Redox Signaling, and Metal Chelation in Anthracycline Cardiotoxicity and Pharmacological Cardioprotection

“…Taken together, this provided a strong rationale for studies of ANT cardiotoxicity prevention with iron chelators. While the classical antioxidants scavenge the ROS once they had been formed, chelators are able to prevent the formation of highly toxic OH through the ironcatalyzed Fenton and Haber-Weiss reactions (68,84).…”

Iron(III) Complexation by New Aminocarboxylate Chelators − Thermodynamic and Kinetic Studies

“…The main reason is probably that the design of such systems is potentially problematic for medicinal chemists in terms of safety margins owing to the possible interaction of chelators with normal iron metabolism. [6] We recently developed a new strategy based on the idea that an ''ideal'' iron chelator for use in oxidative stress-related conditions should effectively chelate iron only in prooxidant conditions. We therefore explored the possibility of generating pro-drugs that can be oxidatively activated into species with strong iron-binding capacity.…”

Phytate Degradation During Traditional Cooking: Significance of the Phytic Acid Profile in Cereal-Based Vegetarian Meals

“…Furthermore, it has been claimed that phytic acid is a potent antioxidant which inhibits Fenton reactions leading to lipid peroxidation and inhibition of polyphenol oxidase (Galey, 1997). Recent studies have shown IP3 to be an anti-carcinogen which protects against colon cancer (Shamsuddin, 1995).…”