Potential toxic effects produced by L-mimosine in the thyroid and reproductive systems. Evaluation in male rats

Gotardo, André Tadeu; Dipe, Vânius Vinicius; Almeida, Elaine Renata Motta de; Hueza, Isis Machado; Pfister, James A.; Górniak, Silvana Lima

doi:10.1016/j.toxicon.2021.10.003

Cited by 6 publications

(3 citation statements)

References 51 publications

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“…The differential diagnosis for sheep with diffuse alopecia includes poisoning by the plant Leucaena leucocephala, characterized by weight loss, ulcerations of the tongue and esophagus, sialorrhea, goiter, infertility, or death [48,49]. These clinical signs result from the action of mimosine [50], which prevents iodine peroxidation in the thyroid (iodination), with a decreased synthesis of T3 and T4 [51].…”

Section: Discussionmentioning

confidence: 99%

Diffuse Alopecia and Thyroid Atrophy in Sheep

Sampaio

Riet-Correa

Barbosa

et al. 2021

Animals

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Thyroid dysfunction substantially affects the quality of life due to its association with various disorders in different organs. A low intake of selenium and zinc can predispose to thyroid alterations, resulting in hypothyroidism. A deficiency of selenium and zinc causes direct and indirect skin lesions, both by the action of free radicals on the skin and by thyroid dysfunction. The aim of this study was to describe natural cases of diffuse alopecia and thyroid abnormalities in sheep with selenium and zinc deficiency. Five adult sheep presented marked and diffuse alopecia, and the residual hairs were dry and brittle. The skin was thick and crusty, with marked peeling. The triiodothyronine (T3) and thyroxine (T4) serum concentrations were below reference values for the species. Zinc and Se concentrations were low in both the serum and liver. During necropsy, cachexia associated with serous fat atrophy was observed, and the thyroid glands showed marked atrophy. Microscopically, the thyroid presented multifocal to coalescent atrophy, with atrophied and dilated follicles, macrophage infiltration, and the presence of fibrous connective tissue. The skin revealed hyperkeratosis and edema. It is concluded that thyroid atrophy, alopecia, and hyperkeratosis are associated with low serum and liver concentrations of zinc and selenium in sheep.

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Section: Discussionmentioning

confidence: 99%

Diffuse Alopecia and Thyroid Atrophy in Sheep

Sampaio

Riet-Correa

Barbosa

et al. 2021

Animals

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“…Efek toksik dari mimosin berpengaruh pada sapi, domba, kambing, babi, kuda, unggas, kelinci, dan tikus (Fayemi et al, 2011;Porto et al, 2017;Vijayakumar dan Srinivasan, 2018;Loh et al, 2020;Gotardo et al, 2021). Ternak ruminansia seperti sapi, kambing dan domba meskipun diketahui dapat mengubah mimosin menjadi 3,4 dihidroksipiridin (DHP) sehingga lebih tahan terhadap toksik mimosin, keracunan akibat mimosin juga terjadi seperti mengalami rendahnya kenaikan berat badan, alopecia, gondok, kesuburan reproduksi rendah, mengalami aborsi hingga kematian.…”

Section: Abstrakunclassified

“…Toksisitas mimosin berupa gangguan fertilitas pada hewan jantan dapat terjadi karena penggabungan mimosin dalam sekresi tirosin menjadi protein biologis yang dibutuhkan dalam proses pembentukkan hormon tiroid (Gotardo et al, 2021). Adanya mimosin mengakibatkan terhambatnya pengikatan iodine yang dibutuhkan dalam sekresi hormon tiroid (Archibong dan Abdelgadir, 2016).…”

Section: Pembuatan Preparat Histologiunclassified

The Effect of Mimosine From Simplicia of the Lamtoro Leaf on the Histopatological of White Rats’ Testis

Jessica Oktavia Simanjuntak,

Berata,

Winaya

et al. 2024

bulvet

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Lamtoro leaves (Leucaena leucocephala) are often used as cattle feed. Lamtoro leaf feeding causes decrease in sperm concentration, in diameter of the seminiferous tubules, impaired spermatogenesis, cell degeneration and atrophy. This research aims to determine the histopathology of the testes of white rat given mimosine at different doses. This research uses 20 of 2 months old male Wistar strain white rat with 300-350 g body weight. This research used a completely randomized design (CRD) with 4 treatments, which is P0 (negative control), P1 (positive control) is given mimosine standard 5 mg/day/head, P2 is given lamtoro leaf simplicia 50 mg/day/head and P3 is given leaf simplicia lamtoro 150 mg/day/head. Treatment was given for 14 days orally and on the 15th day a necropsy of testicular organ was taken. Histopathological examination was carried out based on the presence of congestion and necrosis lesions in the seminiferous tubules. Data from testicular histopathological examination results were scored based on severity consisting of, 0 = no lesions; 1= mild lesion (focal); 2= moderate lesion (multifocal); 3 = severe (diffuse), then analyzed with the Kruskal-Wallis and Mann-Whitney tests. The results of the study showed that administration of mimosine from lamtoro leaf simplisia could cause congestion and necrosis compared to control and treatment. Administration of mimosine dose 5 mg/day/ head (P1) causes congestion and necrosis while administration of mimosine from lamtoro leaf simplicia dose 50 mg / head / day (P3) does not cause lesions and dose 150 mg/day/ head (P2) causes congestion in the testicles.

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