Potential Technetium Small Molecule Radiopharmaceuticals

Synthesis and structural characterization of rhenium(I) tricarbonyl complexes with the bidentate ligands o-(diphenylphosphino)benzaldehyde (P∩O) and o-[(diphenylphosphino)benzylidene]analine (P∩N)

“…The gamma-emitting radionuclide 99m Tc and its Group VII congener 186/188 Re have found wide-ranging applications in radiodiagnosis [1][2][3][4][5][6] and radiotherapy [7,8], respectively. The optimal nuclear properties of 99m Tc (γ-emitter, E max = 140 keV, t 1/2 = 6 h), as well as its convenient availability from 99 Mo/ 99m Tc generator system [9], have made 99m Tc radiopharmaceuticals virtually ideal for imaging low capacity high density receptors by deploying SPECT (single photon emission computerized tomography), while both isotopes 186 Re (t 1/2 = 90.64 h, E max = 1.1 MeV) and 188 Re (t 1/2 = 17 h, E max = 2.1 MeV) are suitable for therapeutic use b y means of β-irradiation.…”

An unexpected ‘4+2’ [N3S]/[NS] rhenium(IV) complex formed upon cleavage of a Re(V) imido bond

“…The continuing expansion of the coordination chemistry of the Group VII elements technetium and rhenium reflects the application of their radionuclides to the development of radiopharmaceuticals [1][2][3][4][5]. 99m Tc-based radiopharmaceuticals continue to provide the mainstay in diagnostic nuclear medicine due to the optimal nuclear properties (t 1/2 = 6.02 h, E g = 142 keV) and easy availability from 99 Mo/ 99m Tc generator [6].…”

“…An ideal conceptual design would provide six-coordinate {Re=N-R} complexes with maximum stability, which hold a pre-organized pentadentate ligand with four coplanar donor atoms and the fifth group perpendicular to the basal plane and trans to the metal-imido bond. 2 ] with 1 utilizing triethylamine as base to neutralize the HCl produced in situ. We herein report the synthesis of a novel '4+2' rhenium(IV) complex 4 whose structure is defined by a highly distorted six-coordinate geometry featuring the [N 3 S] donor set of ligand 3, a partially self-condensed thiazolidine derivative of ligand 1, whose N 3 S donors define a trapezoidal plane and the [NS] donors of the doubly deprotonated form of 2-aminothiophenol, (NHC 6 H 4 S) 2− , in the apical positions.…”

Structural characterizations of an Re(IV) complex [ReCl4(OPPh3)2] and of an imino species [ReOCl2(PPh3)(η2-OC6H4-2-CHNH)] prepared from the reaction of [ReOCl3(PPh3)2] with salicylaldoxime

“…The widespread contemporary interest in the development of technetium and rhenium radiopharmaceuticals [1][2][3][4][5] has fostered a dramatic expansion of the coordination chemistry of these metals. One persistent strategy has focused on developing effective chelating ligands for the robust and ubiquitous {MO} 3+ core (M = Tc, Re).…”