Potential Targets and Mechanisms of Dalbergia odorifera on Treating Lung Adenocarcinoma Explored by Network Pharmacology

Abstract

Background and Objective: Dalbergia odorifera (DO) is a medicinally important plant which showed anticancer effects in osteosarcoma and neuroblastoma, however, it lacks data on Lung Adenocarcinoma (LUAD). Therefore, the effect of DO on LUAD was explored in this study. Materials and Methods: The main active components of DO, targets of DO and LUAD disease targets were obtained from databases including the TCMSP and Gene Cards. While, the top 10 hub targets of overlapping genes were analyzed by the topological structure (CytoNCA), Molecular Complex Deletion (MCODE) plugin and cytoHubba. Moreover, the correlation between hub gene expression and LUAD was confirmed on the Gene Expression Profiling Interactive Analysis Dataset (GEPIA). Results: A total of 37 core active components were selected according to the screening criteria of ADME OB>30% and DL>0.18. While 627 genes overlapped between targets of DO and LUAD, of which STAT3, EGFR, SRC, PTK2, PTPN11, MAPK1, LYN, LCK, CTNNB1 and MAPK3 were defined as the hub genes involved in the anti-LUAD effects of DO. Moreover, the mRNA expression of LCK is associated with the prognosis stages and median survival time of LUAD. Conclusion: The application of network pharmacology analysis provides a theoretical mechanism for the pharmacological effect of DO against LUAD.