Potential roles of metalloproteinases of endometrium‐derived exosomes in embryo‐maternal crosstalk during implantation

Latifi, Zeinab; Fattahi, Amir; Ranjbaran, Ali; Nejabati, Hamid Reza; Imakawa, Kazuhiko

doi:10.1002/jcp.26259

Cited by 36 publications

(26 citation statements)

References 188 publications

(220 reference statements)

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“…and "cell surface receptor signaling pathway") [41,42]. Notably, a previous study has suggested that G-protein coupled receptor may play a vital role in embryo-maternal crosstalk during the period of maternal recognition and establishment of pregnancy [43].…”

Section: Highly Abundant Mirnas Might Influence Endometrial Receptivementioning

confidence: 99%

Small RNA-seq analysis of extracellular vesicles from porcine uterine flushing fluids during peri-implantation

Hua

Wang²,

Lian

et al. 2021

Gene

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Section: Highly Abundant Mirnas Might Influence Endometrial Receptivementioning

confidence: 99%

Small RNA-seq analysis of extracellular vesicles from porcine uterine flushing fluids during peri-implantation

Hua

Wang²,

Lian

et al. 2021

Gene

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“…

Implantation is dependent on various factors including embryo quality, endometrial receptivity, embryo-endometrial crosstalk, and immunological factors. [1][2][3][4] Indeed, two-thirds of gestation failures occur due to the uterine dysfunction and the embryo is only responsible for one-third of the failures. 5,6 As the embryo expresses paternal antigens that are foreign to the mother immune system, the pregnancy is considered as a semi-allograft.

…”

mentioning

confidence: 99%

Lymphocytes immunotherapy for preserving pregnancy: Mechanisms and Challenges

Taheri

Nejabati

Latifi

et al. 2018

American J Rep Immunol

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Due to the expression of paternal antigens by the embryo, pregnancy is considered as a semi-allograft and so immunological dysregulation is considered as one of the important causes in repeated implantation failure (RIF) and recurrent pregnancy loss (RPL). It has been revealed that lymphocytes immunotherapy (LIT) could be an appropriate approach to prevent pregnancy loss in such patients. Various mechanisms have been suggested for effectiveness of LIT such as enhancing expression of anti-paternal cytotoxic antibodies (APCA), progesterone-induced blocking factor (PIBF), anti-idiotypic antibodies (Ab2), and mixed lymphocyte reaction blocking antibodies (MLR-Bf), as well as reduction in the T helper 1/T helper 2 ratio and deviation in the pattern of cytokines production. However, there are controversial results about the beneficial effect of LIT treatment in RIF and RPL patients. In the current study, we reviewed findings of LIT in RIF and RPL patients with a focus on possible mechanisms of alloimmunization in preserving pregnancy. Besides, we highlighted possible reasons for mixed results about the effectiveness of LIT and way of solving the problem. Also, we proposed potential laboratory and clinical criteria to recruit patients for LIT.

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“…For example, MMP-14 and ADAM10, present in endometrium-derived exosomes, act on IL-8, TGFb, CD44, Notch and its ligand DLL1 promoting their bioactivity [40][41][42][43]. For reference, a recent comprehensive review has summarized the roles of MMPs in embryo-maternal crosstalk [44].…”

Section: Paracrine-cytokines Chemokinesmentioning

confidence: 99%

Mother and Embryo Cross-Communication

Idelevich¹,

Vilella

2020

Genes

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Endometrial receptivity is a biosensor for embryo quality, as embryos with reduced developmental potential are rejected. However, embryo quality only accounts for an estimated one-third of implantation failures, with suboptimal endometrial receptivity accounting for the remaining two-thirds. As pregnancy progresses, a uterus continues to engage in close communication with an embryo/fetus, exchanging information in the form of endocrine, paracrine, and other cues. Given the long mammalian gestation period, this dialogue is intricate, diverse, and, currently, not fully understood. Recent progress and the availability of high-throughput techniques, including transcriptomics, proteomics, and metabolomics, has allowed the simultaneous examination of multiple molecular changes, enhancing our knowledge in this area. This review covers the known mechanisms of mother–embryo cross-communication gathered from animal and human studies.

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Potential roles of metalloproteinases of endometrium‐derived exosomes in embryo‐maternal crosstalk during implantation

Cited by 36 publications

References 188 publications

Small RNA-seq analysis of extracellular vesicles from porcine uterine flushing fluids during peri-implantation

Small RNA-seq analysis of extracellular vesicles from porcine uterine flushing fluids during peri-implantation

Lymphocytes immunotherapy for preserving pregnancy: Mechanisms and Challenges

Mother and Embryo Cross-Communication

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