Potential roles and molecular mechanisms of phytochemicals against cancer

Zheng, Zhaodi; Zhang, Leilei; Hou, Xitan

doi:10.1039/d2fo01663j

Cited by 23 publications

(12 citation statements)

References 112 publications

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“…Phytochemicals have gained much interest in research due to their remarkable anticancer properties and are believed to be a potential alternative to anticancer therapy . Furthermore, phytochemicals combined with chemotherapeutic agents target multiple signal cascades to chemosensitize cancer cells to drugs, representing a novel and potentially effective therapeutic strategy. ,, Phytochemicals have been shown to suppress cancer by modulating various signal transduction pathways and employing the anticancer effect by promoting cellular apoptosis, cell proliferation, and inhibiting self-renewal pathways that are responsible for CSC survival (Figure ). , However, to improve the limitations and translational success of phytochemicals, researchers have focused their efforts on developing phytochemical-based nanoformulations or phytonanomedicine for specific tumor targeting abilities with minimal off-target effects for better therapeutic outcomes. ,,, Therefore, nanomedicine strategies are mainly employed to enhance the therapeutic index by inhibiting cancer survival signals and modulating TME.…”

Section: Opportunities For Phytonanomedicine In Cancer Therapymentioning

confidence: 99%

Phytochemical-Based Nanomedicine for Targeting Tumor Microenvironment and Inhibiting Cancer Chemoresistance: Recent Advances and Pharmacological Insights

Sa,

Mohapatra,

Swain

et al. 2023

Mol. Pharmaceutics

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Cancer remains the leading cause of death and rapidly evolving disease worldwide. The understanding of disease pathophysiology has improved through advanced research investigation, and several therapeutic strategies are being used for better cancer treatment. However, the increase in cancer relapse and metastatic-related deaths indicate that available therapies and clinically approved chemotherapy drugs are not sufficient to combat cancer. Further, the constant crosstalk between tumor cells and the tumor microenvironment (TME) is crucial for the development, progression, metastasis, and therapeutic response to tumors. In this regard, phytochemicals with multimodal targeting abilities can be used as an alternative to current cancer therapy by inhibiting cancer survival pathways or modulating TME. However, due to their poor pharmacokinetics and low bioavailability, the success of phytochemicals in clinical trials is limited. Therefore, developing phytochemical-based nanomedicine or phytonanomedicine can improve the pharmacokinetic profile of these phytochemicals. Herein, the molecular characteristics and pharmacological insights of the proposed phytonanomedicine in cancer therapy targeting tumor tissue and altering the characteristics of cancer stem cells, chemoresistance, TME, and cancer immunity are well discussed. Further, we have highlighted the clinical perspective and challenges of phytonanomedicine in filling the gap in potential cancer therapeutics using various nanoplatforms. Overall, we have discussed how clinical success and pharmacological insights could make it more beneficial to boost the concept of nanomedicine in the academic and pharmaceutical fields to counter cancer metastases and drug resistance.

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Section: Opportunities For Phytonanomedicine In Cancer Therapymentioning

confidence: 99%

Phytochemical-Based Nanomedicine for Targeting Tumor Microenvironment and Inhibiting Cancer Chemoresistance: Recent Advances and Pharmacological Insights

Sa,

Mohapatra,

Swain

et al. 2023

Mol. Pharmaceutics

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“…They regulate cancer cell proliferation, migration, angiogenesis, and drug resistance [ 56 ]. Several terpenoids have been demonstrated to operate as autophagy modulators against tumor drug resistance and enhance chemotherapeutic and synthetic drug sensitivity [ 57 ]. Andrographolide (AG), a diterpene lactone from Andrographis paniculate, exerts anti-inflammatory, antiviral, and neuroprotective properties [ 58 ].…”

Section: Natural Products Overcome Autophagy-mediated Tumor Drug Resi...mentioning

confidence: 99%

Focusing on the Role of Natural Products in Overcoming Cancer Drug Resistance: An Autophagy-Based Perspective

Yao

Feng

et al. 2022

Biomolecules

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Autophagy is a critical cellular adaptive response in tumor formation. Nutritional deficiency and hypoxia exacerbate autophagic flux in established malignancies, promoting tumor cell proliferation, migration, metastasis, and resistance to therapeutic interventions. Pro-survival autophagy inhibition may be a promising treatment option for advanced cancer. Furthermore, excessive or persistent autophagy is cytotoxic, resulting in tumor cell death. Targeted autophagy activation has also shown significant promise in the fight against tumor drug resistance. Several research groups have examined the ability of natural products (NPs) such as alkaloids, terpenoids, polyphenols, and anthraquinones to serve as autophagy inhibitors or activators. The data support the capacity of NPs that promote lethal autophagy or inhibit pro-survival autophagy from being employed against tumor drug resistance. This paper discusses the potential applications of NPs that regulate autophagy in the fight against tumor drug resistance, some limitations of the current studies, and future research needs and priorities.

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“…Magnolol was shown to have an apparent apoptotic impact in SGC-7901 human gastric cancer cells [ 16 ]. Magnolol and its methoxylated derivative, 2-O-methyl magnolol, were recently found to inhibit the proliferation, migration, and invasion of hepatocellular carcinoma cell lines by inducing p21 and p53 activation [ 17 ]. The anti-tumor effects of magnolol and 2-O-methyl magnolol in vivo were also established [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Magnolol Anticancer Potential in MKN-45 Gastric Cancer Cells

et al. 2023

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Background and Objectives: Combination therapy improves the effect of chemotherapy on tumor cells. Magnolol, used in treating gastrointestinal disorders, has been shown to have anti-cancer properties. We investigated the synergistic effect of cisplatin and magnolol on the viability and maintenance of MKN-45 gastric cancer cells. Materials and Methods: The toxicity of magnolol and/or cisplatin was determined using the MTT technique. The trypan blue method was used to test magnolol and/or cisplatin’s effect on MKN-45 cell growth. Crystal violet staining was used to assess the treated cells’ tendency for colony formation. The expression of genes linked to apoptosis, cell cycle arrest, and cell migration was examined using the qPCR method. Results: According to MTT data, using magnolol and/or cisplatin significantly reduced cell viability. The ability of the treated cells to proliferate and form colonies was also reduced considerably. Magnolol and/or cisplatin treatment resulted in a considerable elevation in Bax expression. However, the level of Bcl2 expression was dramatically reduced. p21 and p53 expression levels were significantly increased in the treated cells, while MMP-9 expression was significantly reduced. Conclusions: These findings show that magnolol has a remarkable anti-tumor effect on MKN-45 cells. In combination with cisplatin, magnolol may be utilized to overcome cisplatin resistance in gastric cancer cells.

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Potential roles and molecular mechanisms of phytochemicals against cancer

Abstract: Increasing evidence has been reported regarding phytochemicals, plant secondary metabolites, having therapeutic functions against numerous human diseases.

Cited by 23 publications

References 112 publications

Phytochemical-Based Nanomedicine for Targeting Tumor Microenvironment and Inhibiting Cancer Chemoresistance: Recent Advances and Pharmacological Insights

Phytochemical-Based Nanomedicine for Targeting Tumor Microenvironment and Inhibiting Cancer Chemoresistance: Recent Advances and Pharmacological Insights

Focusing on the Role of Natural Products in Overcoming Cancer Drug Resistance: An Autophagy-Based Perspective

Evaluating the Magnolol Anticancer Potential in MKN-45 Gastric Cancer Cells

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