Potential role of β-elemene on histone H1 in the H22 ascites hepatoma cell line

Bao, Fazhen; Qiu, Jie; Zhang, Hong

doi:10.3892/mmr.2012.891

Cited by 11 publications

(7 citation statements)

References 29 publications

(31 reference statements)

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“…According to the study, beta-elemene can suppress the growth of H22 cells through increasing the expression of histone H1 protein. These findings indicated that beta-elemene may be a potential antitumor agent for liver cancer treatment [ 174 ].…”

Section: Recent Research On the Roles Of Herbs And Phytochemicals mentioning

confidence: 99%

Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects

Hong

Tan

et al. 2015

IJMS

141

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Chronic liver dysfunction or injury is a serious health problem worldwide. Chronic liver disease involves a wide range of liver pathologies that include fatty liver, hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. The efficiency of current synthetic agents in treating chronic liver disease is not satisfactory and they have undesirable side effects. Thereby, numerous medicinal herbs and phytochemicals have been investigated as complementary and alternative treatments for chronic liver diseases. Since some herbal products have already been used for the management of liver diseases in some countries or regions, a systematic review on these herbal medicines for chronic liver disease is urgently needed. Herein, we conducted a review describing the potential role, pharmacological studies and molecular mechanisms of several commonly used medicinal herbs and phytochemicals for chronic liver diseases treatment. Their potential toxicity and side effects were also discussed. Several herbal formulae and their biological effects in chronic liver disease treatment as well as the underlying molecular mechanisms are also summarized in this paper. This review article is a comprehensive and systematic analysis of our current knowledge of the conventional medicinal herbs and phytochemicals in treating chronic liver diseases and on the potential pitfalls which need to be addressed in future study.

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Section: Recent Research On the Roles Of Herbs And Phytochemicals mentioning

confidence: 99%

Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects

Hong

Tan

et al. 2015

IJMS

141

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“…Curcuma zedoaria , the dried rhizome of Zingiberaceae plants, has previously been revealed to exhibit antitumor, antithrombotic and antibacterial effects, and has been used to treat many types of cancer in traditional Chinese medical practices ( 14 ). β-elemene, an extractable monomer from Curcuma zedoaria oil, has a wide antineoplastic spectrum, without toxic effects, and has been approved as an auxiliary treatment in China ( 8 ). Previous studies have revealed that the anticancer effects of β-elemene are predominantly due to the inhibition of tumor cell proliferation at a certain stage in the cell cycle, in addition to increased levels of apoptosis ( 7 – 9 ).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of β-elemene via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells

Wang

Zhao

et al. 2018

Mol Med Report

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Concurrent radio chemotherapy treatment prolongs the survival rate of patients with advanced cervical cancer; however, it has adverse side-effects. β-elemene, an active component of the traditional Chinese medicinal herb Curcuma zedoaria, is a promising alternative therapeutic drug for the treatment of advanced cervical cancer. The aim of the present study was to investigate the antitumor effects of β-elemene in human cervical cancer SiHa cells and to determine its underlying therapeutic molecular mechanisms. Cell viability, cell cycle progression and apoptosis were detected using an MTT assay and flow cytometry analysis. Furthermore, the levels of cell migration and cell invasion were investigated using Transwell and wound healing assays. The expression levels of Cyclin-dependent kinase inhibitor 2B (P15), Cyclin D1, cellular tumor antigen p53, apoptosis regulator Bcl-2 (Bcl-2), apoptosis regulator BAX (Bax), 72 kDa type IV collagenase (MMP-2), matrix metalloproteinase-9 (MMP-9), β-catenin, transcription factor 7 (TCF7), and Myc proto-oncogene protein (c-Myc) were analyzed via western blotting. The results revealed that β-elemene inhibited the proliferation of SiHa cells in a dose and time-dependent manner. Administration of β-elemene induced G1 phase cell-cycle arrest, as demonstrated by the upregulation of P15 expression and the downregulation of Cyclin D1 expression. Furthermore, the present study revealed that β-elemene induced apoptosis in SiHa cells by enhancing the expression of p53 and Bax, and suppressing the expression of Bcl-2. In addition, treatment with β-elemene inhibited cell migration and invasion via downregulation of MMP-2 and MMP-9 expression levels. Western blotting demonstrated that β-elemene reduced the expression levels of β-catenin and its downstream target molecule TCF7, thus resulting in reduced levels of their target proteins, including c-Myc, Cyclin D1, Bax and MMP-2 in cervical cancer cells. The results of the present study suggested that β-elemene may inhibit cell proliferation and invasion, in addition to inducing apoptosis, via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells.

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“…Similarly, most experimental studies of β -elemene targeting hepatobiliary diseases have been related to cancer. In mice models transplanted with human HCC cell lines (H22 [ 76 ] and MHCC97H cells [ 77 ]), β -elemene reduced the weight and volume of the tumor tissue. In particular, β -elemene enhanced the sensitivity of the anticancer drugs by increasing the level of copper transporter 1, aiding in the uptake of oxaliplatin into liver cells [ 77 ].…”

Section: Pharmacological Activities Of Active Compounds Isolated Fmentioning

confidence: 99%

“…In particular, β -elemene enhanced the sensitivity of the anticancer drugs by increasing the level of copper transporter 1, aiding in the uptake of oxaliplatin into liver cells [ 77 ]. Based on the underlying mechanisms of its anticancer effects, β -elemene inhibited the proliferation of cancer cells by increasing histone H1 protein in H22 cells [ 76 ], and its treatment induced G2/M arrest and apoptosis of HepG2 cells by augmenting Fas and FasL mRNA and proteins on the cellular surface [ 75 ].…”

Section: Pharmacological Activities Of Active Compounds Isolated Fmentioning

confidence: 99%

Preclinical Evidence of Curcuma longa and Its Noncurcuminoid Constituents against Hepatobiliary Diseases: A Review

Jang

Lee

2020

Evidence-Based Complementary and Alternative Medicine

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Hepatobiliary disease currently serves as an important public health issue due to the fact that it is one of the major causes of death among economically active individuals and can easily progress to chronic diseases. Despite the development of vaccines and numerous drugs, a definite treatment remains lacking owing to different stages of the disease itself, its intricate pathogenesis, an effect uncertainty for long-term use, resistance, and side effects. Curcuma longa (C. longa), which belongs to the family Zingiberaceae and the genus Curcuma, has long been used not only as spice for curry or dye but also as a constituent of herbal formula for the treatment of different diseases due to its bioactive activities. Recently, many studies on the experimental results of C. longa have been published relative to hepatobiliary diseases such as fatty liver, hepatitis, cirrhosis, and tumors. Therefore, in this review, we aimed to summarize the pharmacological effects and underlying molecular mechanisms of C. longa and its four compounds, β-elemene, germacrone, ar-turmerone, and bisacurone, against hepatobiliary diseases. C. longa exhibited antioxidant, hepatoprotective, antisteatotic, anti-inflammatory, antifibrotic, antitumor, and cholagogic effects by regulating apoptosis, CYP2E1, Nrf, lipid metabolism-related factors, TGF-β, NF-κB, CYP7A1, and so on. In particular, β-elemene could be an attractive compound owing to its remarkable hepatoprotective, anti-inflammatory, antifibrotic, and antitumor activities. Altogether, the present review provides a preclinical basis for the efficacy of C. longa as an effective therapeutic agent for the prevention and treatment of hepatobiliary diseases, despite the need for further studies to establish the extraction conditions and separation of active constituents with high bioavailability, and warrants further evaluation in clinical trials.

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Potential role of β-elemene on histone H1 in the H22 ascites hepatoma cell line

Cited by 11 publications

References 29 publications

Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects

Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects

Therapeutic effects of β-elemene via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells

Preclinical Evidence of Curcuma longa and Its Noncurcuminoid Constituents against Hepatobiliary Diseases: A Review

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