Potential Role of Selenium Against Hepatotoxicity Induced by 2,4-Dichlorophenoxyacetic Acid in Albino Wistar Rats

Tichati, Lazhari; Trea, Fouzia; Ouali, Kheireddine

doi:10.1007/s12011-019-01773-9

Cited by 24 publications

(23 citation statements)

References 52 publications

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“…MDA levels were measured using the method described by Ohkawa et al (Ohkawa et al, 1979). Catalase and glutathione peroxidase (GPX) levels were measured as described elsewhere (Aebi, 1984;Tichati et al, 2020). Serum levels of cytokines were measured using Sandwich-ELISA kits following the procedures in the instruction manual supplied by the company.…”

Section: Biochemical Cytokine and Renal Oxidative Stress Measurementsmentioning

confidence: 99%

Impact of Thymus vulgaris extract on sodium nitrite‐induced alteration of renal redox and oxidative stress: Biochemical, molecular, and immunohistochemical study

Soliman

Aldhahrani

Alghamdi

et al. 2021

Journal of Food Biochemistry

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Thyme (Thymus vulgaris) is an herbal plant with pleiotropic medicinal properties. In this study, we examined the possible protective effect of an ethanolic extract of thyme leaves against the renal oxidative stress induced by sodium nitrite (NaNO 2 ). Male Swiss mice received either saline or thyme extract for 15 days (0.5 g/kg body weight, orally). NaNO 2 (60 mg/kg) was injected intraperitoneally at Day 14. The protective group received the thyme extract for 15 days and NaNO 2 on Day 14. Blood and kidney samples were taken from all groups to measure serum urea, blood urea nitrogen (BUN), creatinine, serum, tissue antioxidant activity, and the inflammatory cytokines IL-1β and IL-6. Quantitative real-time PCR (qRT-PCR) was used to examine the expression of kidney injury marker-1 (Kim-1), TNFα, nuclear factor erythroid-2 related factor 2 (Nrf2), and hemoxygenase-1 (HO-1), all of which are associated with kidney redox and oxidative stress. Pretreatment with thyme extract reduced the effects of NaNO 2 on urea, BUN, and creatinine, and reversed its effect on tissue and serum antioxidants.NaNO 2 -induced nephritis as demonstrated by the upregulation in mRNA expression of Kim-1 and TNFα, which was, however, recovered and protected by pretreatment with thyme extract. Expression of Nrf2 and HO-1 was upregulated by treatment with thyme extract and downregulated by NaNO 2 intoxication. NaNO 2 -induced congestion in glomeruli and dilatation of the renal tubules, conditions that were restored in the group pretreated with thyme extract. NaNO 2 upregulated Bax immunoreactivity and caused apoptosis in renal structures. Thus, thyme extract is effective in managing the renal toxicity associated with oxidative stress and renal redox. Practical applicationsThe results from this study have shown that use of thyme extract may promote better health due to its high antioxidant activity. For instance, it could be ingested to alleviate the symptoms of renal inflammation and oxidative stress associated with nitrite toxicity. Thyme extract regulated renal redox, oxidative stress, antioxidant levels, and inflammation-associated genes at the molecular, biochemical, and cellular immunohistochemical levels.

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Section: Biochemical Cytokine and Renal Oxidative Stress Measurementsmentioning

confidence: 99%

Impact of Thymus vulgaris extract on sodium nitrite‐induced alteration of renal redox and oxidative stress: Biochemical, molecular, and immunohistochemical study

Soliman

Aldhahrani

Alghamdi

et al. 2021

Journal of Food Biochemistry

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“…Reactive oxygen species are likely to impair the activity of these systems. Nevertheless, antioxidant molecules like vitamins C and E and trace elements as zinc are important for strengthening the body's antioxidant defenses and preventing oxidative stress [4].…”

Section: Introductionmentioning

confidence: 99%

Effect of Zinc Deficiency on Blood Glucose, Lipid Profile, and Antioxidant Status in Streptozotocin Diabetic Rats and the Potential Role of Sesame Oil

Beloucif

Kechrid

Bekada

2021

Biol Trace Elem Res

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Zinc is recognized to have a crucial function in insulin production. As a result, its absence may have a deleterious impact on the progression of diabetes and associated consequences. So, this study was undertaken to evaluate the effect of sesame oil on biochemical parameters, zinc status, and oxidative stress biomarkers in streptozotocin (STZ)-induced diabetic rats fed zinc-deficient diet. Rats were divided into four groups. The first group consisted of non-diabetic rats that were fed in a sufficient zinc diet, whereas the second was a diabetic group which received also sufficient zinc diet, while the third and fourth groups were diabetic rats fed in a deficient zinc diet, one was non-treated and the other was treated with sesame oil 6% diet for 27 days. Zinc deficiency has affected the weight of the diabetic animals. It was also noticed that inadequate dietary zinc intake increased concentrations of glucose, cholesterol, triglycerides, malondialdehyde, and transaminases activities. Furthermore, zinc deficiency feed provoked a decrease in zinc level in tissues (femur, liver, and pancreas); glutathione concentration; and lactic dehydrogenase, amylase, catalase, superoxide dismutase, and glutathione-S-transferase activities. However, sesame oil treatment ameliorated all the previous parameters approximately to their normal values. It was found out that sesame oil supplementation is a potent factor in mitigating the oxidative severity of zinc deficiency in diabetes through its effective antioxidant potential.

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“…Pesticides may adversely affect hematopoietic tissue and liver functions in populations chronically exposed to high levels of these compounds [ 121 ]. Some experimental studies by Brazilian groups corroborate the evidence for pesticide hepatotoxicity, disrupting biochemical parameters, and antioxidant capacity.…”

Section: Resultsmentioning

confidence: 99%

Impact of Pesticides on Human Health in the Last Six Years in Brazil

Lopes-Ferreira

Maleski

Balan-Lima

et al. 2022

IJERPH

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Every year, Brazil intensifies its activity in agriculture and, as a result, it has become one of the biggest consumers of pesticides in the world. The high rate of these substances raises environmental and human health concerns. Therefore, we collected papers from PubMed, Scopus, Scielo, and Web of Science databases, from 2015 to 2021. After a blind selection using the software Rayyan QCRI by two authors, 51 studies were included. Researchers from the South and the Southeast Brazilian regions contributed to most publications, from areas that concentrate agricultural commodity complexes. Among the pesticides described in the studies, insecticides, herbicides, and fungicides were the most frequent. The articles reported multiple toxic effects, particularly in rural workers. The results obtained can be used to direct policies to reduce the use of pesticides, and to protect the health of the population.

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Potential Role of Selenium Against Hepatotoxicity Induced by 2,4-Dichlorophenoxyacetic Acid in Albino Wistar Rats

Cited by 24 publications

References 52 publications

Impact of Thymus vulgaris extract on sodium nitrite‐induced alteration of renal redox and oxidative stress: Biochemical, molecular, and immunohistochemical study

Impact of Thymus vulgaris extract on sodium nitrite‐induced alteration of renal redox and oxidative stress: Biochemical, molecular, and immunohistochemical study

Effect of Zinc Deficiency on Blood Glucose, Lipid Profile, and Antioxidant Status in Streptozotocin Diabetic Rats and the Potential Role of Sesame Oil

Impact of Pesticides on Human Health in the Last Six Years in Brazil

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