Potential role of hydrogen sulfide in diabetes-impaired angiogenesis and ischemic tissue repair

Cheng, Zhongjian

doi:10.1016/j.redox.2020.101704

Cited by 51 publications

(36 citation statements)

References 168 publications

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“…Studies have suggested that the cardioprotective effects of H 2 S are mediated through various pathways 71 , 92 – 94 . H 2 S has an important role in promoting angiogenesis and ameliorating type 2 diabetes mellitus that also protect against IRI 8 , 95 , 96 . Endogenous H 2 S production also augments antioxidant signalling via nuclear factor erythroid 2-related factor 2, reduces nuclear factor-κB (NF-κB)-mediated inflammatory signalling and facilitates NO signalling 60 , 97 .…”

Section: Sulfides In the Cardiovascular Systemmentioning

confidence: 99%

Sulfide regulation of cardiovascular function in health and disease

et al. 2022

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Hydrogen sulfide (H 2 S) has emerged as a gaseous signalling molecule with crucial implications for cardiovascular health. H 2 S is involved in many biological functions, including interactions with nitric oxide, activation of molecular signalling cascades, post-translational modifications and redox regulation. Various preclinical and clinical studies have shown that H 2 S and its synthesizing enzymes — cystathionine γ-lyase, cystathionine β-synthase and 3-mercaptosulfotransferase — can protect against cardiovascular pathologies, including arrhythmias, atherosclerosis, heart failure, myocardial infarction and ischaemia–reperfusion injury. The bioavailability of H 2 S and its metabolites, such as hydropersulfides and polysulfides, is substantially reduced in cardiovascular disease and has been associated with single-nucleotide polymorphisms in H 2 S synthesis enzymes. In this Review, we highlight the role of H 2 S, its synthesizing enzymes and metabolites, their roles in the cardiovascular system, and their involvement in cardiovascular disease and associated pathologies. We also discuss the latest clinical findings from the field and outline areas for future study.

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Section: Sulfides In the Cardiovascular Systemmentioning

confidence: 99%

Sulfide regulation of cardiovascular function in health and disease

et al. 2022

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“…The brain, liver, kidney, and other organs produce H 2 S [ 7 ]. The cellular biogenesis of H 2 S is based on the desulfuration of cysteine or homocysteine, a process involving mainly three enzymes: cystathionin-β-synthase (CBS), cystathionin-γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST) [ 61 ]. H 2 S biogenesis at the mitochondria level implies cysteine aminotransferase (CAT) that catalyzes L-cysteine and glutamate to 3-mercaptopyruvate and α-ketoglutarate.…”

Section: Resultsmentioning

confidence: 99%

Recent Advances in Molecular Research on Hydrogen Sulfide (H2S) Role in Diabetes Mellitus (DM)—A Systematic Review

Munteanu

Rotariu

Turnea

et al. 2022

IJMS

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Abundant experimental data suggest that hydrogen sulfide (H2S) is related to the pathophysiology of Diabetes Mellitus (DM). Multiple molecular mechanisms, including receptors, membrane ion channels, signalingmolecules, enzymes, and transcription factors, are known to be responsible for the H2S biological actions; however, H2S is not fully documented as a gaseous signaling molecule interfering with DM and vascular-linked pathology. In recent decades, multiple approaches regarding therapeutic exploitation of H2S have been identified, either based on H2S exogenous apport or on its modulated endogenous biosynthesis. This paper aims to synthesize and systematize, as comprehensively as possible, the recent literature-related data regarding the therapeutic/rehabilitative role of H2S in DM. This review was conducted following the “Preferred reporting items for systematic reviews and meta-analyses” (PRISMA) methodology, interrogating five international medically renowned databases by specific keyword combinations/“syntaxes” used contextually, over the last five years (2017–2021). The respective search/filtered and selection methodology we applied has identified, in the first step, 212 articles. After deploying the next specific quest steps, 51 unique published papers qualified for minute analysis resulted. To these bibliographic resources obtained through the PRISMA methodology, in order to have the best available information coverage, we added 86 papers that were freely found by a direct internet search. Finally, we selected for a connected meta-analysis eight relevant reports that included 1237 human subjects elicited from clinical trial registration platforms. Numerous H2S releasing/stimulating compounds have been produced, some being used in experimental models. However, very few of them were further advanced in clinical studies, indicating that the development of H2S as a therapeutic agent is still at the beginning.

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“…The relation between diabetes-induced endothelial dysfunction and H 2 S impairment is now well established (for review see [ 77 , 97 ]). H 2 S levels have been observed to be reduced in rats with diabetes induced by streptozotocin (STZ) and in subjects with type 2 diabetes mellitus [ 98 , 99 , 100 , 101 , 102 ].…”

Section: Cardiovascular Diseases Associated With Altered Levels Ofmentioning

confidence: 99%

Endothelium as a Source and Target of H2S to Improve Its Trophism and Function

2021

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The vascular endothelium consists of a single layer of squamous endothelial cells (ECs) lining the inner surface of blood vessels. Nowadays, it is no longer considered as a simple barrier between the blood and vessel wall, but a central hub to control blood flow homeostasis and fulfill tissue metabolic demands by furnishing oxygen and nutrients. The endothelium regulates the proper functioning of vessels and microcirculation, in terms of tone control, blood fluidity, and fine tuning of inflammatory and redox reactions within the vessel wall and in surrounding tissues. This multiplicity of effects is due to the ability of ECs to produce, process, and release key modulators. Among these, gasotransmitters such as nitric oxide (NO) and hydrogen sulfide (H2S) are very active molecules constitutively produced by endotheliocytes for the maintenance and control of vascular physiological functions, while their impairment is responsible for endothelial dysfunction and cardiovascular disorders such as hypertension, atherosclerosis, and impaired wound healing and vascularization due to diabetes, infections, and ischemia. Upregulation of H2S producing enzymes and administration of H2S donors can be considered as innovative therapeutic approaches to improve EC biology and function, to revert endothelial dysfunction or to prevent cardiovascular disease progression. This review will focus on the beneficial autocrine/paracrine properties of H2S on ECs and the state of the art on H2S potentiating drugs and tools.

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Potential role of hydrogen sulfide in diabetes-impaired angiogenesis and ischemic tissue repair

Cited by 51 publications

References 168 publications

Sulfide regulation of cardiovascular function in health and disease

Sulfide regulation of cardiovascular function in health and disease

Recent Advances in Molecular Research on Hydrogen Sulfide (H2S) Role in Diabetes Mellitus (DM)—A Systematic Review

Endothelium as a Source and Target of H2S to Improve Its Trophism and Function

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