Potential Role of FDG PET/CT Imaging for Assessing Venous Thromboembolic Disorders

Hess, Søren; Madsen, Poul Thøis; Basu, Sandip; Høilund‐Carlsen, Poul Flemming; Alavi, Abass

doi:10.1097/rlu.0b013e318279bf73

Cited by 17 publications

(14 citation statements)

References 35 publications

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“…Furthermore, we have noted that venous clots due to their high concentration of activated white cells are also readily visualized by FDG-PET ( Fig. 5) [23][24][25][26][27]. We believe this potential application of FDG-PET imaging will likely play a major role in evaluating and treating patients with [15] suspected venous thromboembolic disorders in the near future.…”

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confidence: 99%

The critical role of FDG-PET/CT imaging in assessing systemic manifestations of COVID-19 infection

Alavi

Werner

Gholamrezanezhad

2021

Eur J Nucl Med Mol Imaging

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confidence: 99%

The critical role of FDG-PET/CT imaging in assessing systemic manifestations of COVID-19 infection

Alavi

Werner

Gholamrezanezhad

2021

Eur J Nucl Med Mol Imaging

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“…5 ). 45 , 46 , 47 This is due to the presence of activated white cells and platelets in actively forming clots. Therefore, FDG-PET imaging for assessing patients with cancer will allow detecting the presence of clots throughout the body, including in the lower extremities ( Fig.…”

Section: Practical Clinical Applicationsmentioning

confidence: 99%

Reinventing Molecular Imaging with Total-Body PET, Part II

et al. 2020

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Total-body PET scans will initiate a new era for the PET clinic. The benefits of 40-fold effective sensitivity improvement provide new capabilities to image with lower radiation dose, perform delayed imaging, and achieve improved temporal resolution. These technical features are detailed in the first of this 2-part series. In this part, the clinical impacts of the novel features of total-body PET scans are further explored. Applications of total-body PET scans focus on the real-time interrogation of systemic disease manifestations in a variety of practical clinical contexts. Total-body PET scans make clinical systems biology imaging a reality.

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“…For the time being, FDG-PET/CT will hardly replace compression ultrasound for routine assessment of DVT. However, as previously suggested [10], there may be a role for FDG-PET/CT when looking for VTE in vessels not easily assessed by ultrasound, e.g. iliofemoral vein or veins in very obese patients.…”

Section: Diagnosismentioning

confidence: 86%

“…In general, compression ultrasound has excellent sensitivity in symptomatic patients with proximal lower extremity DVT, but in other clinical settings, the sensitivity may be as low as 21%. In patients with PE, compression ultrasonography of the proximal leg veins found DVT in 29-58%, whereas autopsy studies have found DVT in > 80% [10]. Similarly, CTA and V/Q scans may have excellent sensitivity and specificity when employed in the proper clinical setting, but CTA may miss peripheral PE and contrast media precludes the use in up to 25% of patients.…”

Section: Discussionmentioning

confidence: 99%

“…We previously proposed 18 F-Fluorodeoxyglucose positron emission tomography/computer tomography (FDG-PET/CT) for the diagnosis of VTE as it may overcome shortcomings of other methods [10]. Thus, PET can potentially detect thrombi in any anatomic location of the body, potentially discriminate between acute (FDG-avid) and inactive chronic (nonavid) VTE, as well as potentially differentiate bland thrombus (BT) from tumour thrombus (TT) while automatically screening for occult cancer throughout the body.…”

Section: Vte Is a Common Disease With About 1 Million Reported Cases mentioning

confidence: 99%

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FDG-PET/CT in venous thromboembolism

Hess

Frary

Gerke

et al. 2018

Clin Transl Imaging

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Purpose: Venous thromboembolism (VTE) is common; deep venous thrombosis (DVT) and pulmonary embolism (PE) are the most common presentations. VTE may arise in the entire venous bed and the diagnosis may be difficult. VTE is a dynamic disease, inflammation is key, and FDG-PET/CT has been proposed, e.g. to detect thrombi in any anatomic location, to differentiate acute from chronic VTE, and to differentiate bland VTE from tumor thrombosis. The aim of this systematic review was to assess if the potential uses of 18 F-Fluorodeoxyglucose positron emission tomography/computer tomography (FDG-PET/CT) in VTE are described and documented in the literature. Methods: PubMed and Embase databases were searched. Duplicates and papers in other languages than English and Scandinavian were removed. Remaining papers were screened by title and abstract. Eligible papers were assessed in full-text. Results: The master search yielded 3,897 hits, 316 papers were eligible for full-text assessment. Ten papers were included; six on diagnostic performance of PET/CT in VTE, and four on the ability of PET/CT to differentiate bland VTE from tumor thrombosis. Three papers were prospective, seven were retrospective. Conclusion: If applied early, FDG-PET/CT may have a role in diagnosing DVT, but not PE, to discriminate acute from chronic VTE, and to demonstrate recurrent VTE. FDG-PET/CT is by some considered adept in differentiating bland VTE from tumor thrombosis, but we find this controversial due to FDG avidity in bland VTE. FDG-PET/CT may be feasible when screening for occult malignancy. However, in all mentioned areas, available literature is too sparse and too heterogeneous to allow firm conclusions.

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Potential Role of FDG PET/CT Imaging for Assessing Venous Thromboembolic Disorders

Cited by 17 publications

References 35 publications

The critical role of FDG-PET/CT imaging in assessing systemic manifestations of COVID-19 infection

The critical role of FDG-PET/CT imaging in assessing systemic manifestations of COVID-19 infection

Reinventing Molecular Imaging with Total-Body PET, Part II

FDG-PET/CT in venous thromboembolism

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