Potential role of adenosine deaminase in the diagnosis of adult-onset Still’s disease

Xun, Chunhua; Zhao, Yuqing; Hu, Zhi jian

doi:10.1007/s00296-012-2532-z

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…While some studies reported an association between serum ADA levels and disease activation both in ulcerative colitis and Crohn’s disease[11,24], some others found no relation of serum ADA levels and disease activity in Crohn’s disease[25]. Similarly, it has been shown that ADA levels are associated with disease activation in patients with other autoimmune diseases, such as systemic lupus erythematosus, juvenile idiopathic arthritis, rheumatoid arthritis and Still’s disease[9,10,26,27]. Multiple and complex mechanisms are involved in the pathogenesis of immune-mediated disorders, and this process does not seem to be disease speciﬁc.…”

Section: Discussionmentioning

confidence: 99%

Relationship between serum adenosine deaminase levels and liver histology in autoimmune hepatitis

Torğutalp

Efe

Babaoğlu

et al. 2017

WJG

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AIMTo evaluate the relationship between serum adenosine deaminase (ADA) levels and histological features in patients with autoimmune hepatitis (AIH).METHODSA total of 80 subjects (52 AIH cases and 28 healthy controls) were included in the study. Patients were diagnosed according to the simplified criteria suggested by the International Autoimmune Hepatitis Group. All of the cases had been diagnosed with AIH between 2010-2015 at Hacettepe University, Department of Gastroenterology. Serum blood samples were collected and stored at -80 °C until the biochemical estimation of ADA activity. The diagnosis of patients was confirmed by liver biopsy. Serum ADA > 20 U/L was considered to be high level.RESULTSMean serum ADA levels were significantly higher in AIH patients than those in healthy controls (25.4 ± 9.6 U/L vs 12.8 ± 2.2 U/L, P < 0.001). Serum ADA levels > 20 U/L were found in 63.5% AIH patients and in 0% healthy controls (P < 0.001). Mean serum ADA levels were signiﬁcantly increased in each stage of histological activity: 15.2 ± 3.5 U/L for patients with mild interface hepatitis, 23.1 ± 10.0 U/L for patients with moderate interface hepatitis and 30.9 ± 7.0 U/L for patients with severe interface hepatitis (P < 0.001). Correlation analysis showed that there was a positive association between serum ADA levels and histological activity (r = 0.71, P < 0.001). Receiver operating characteristic analysis suggested that 24.5 U/L was the optimum cut-off point of ADA level for severe interface hepatitis (sensitivity 88%, speciﬁcity 85.2%, area under the curve: 0.88).CONCLUSIONBecause of the positive correlation with inflammatory activity, serum ADA level may be a potential biomarker for predicting or monitoring histological activity in patients with AIH.

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Section: Discussionmentioning

confidence: 99%

Relationship between serum adenosine deaminase levels and liver histology in autoimmune hepatitis

Torğutalp

Efe

Babaoğlu

et al. 2017

WJG

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“…There was a study that showed ADA activity may be a potential marker for the diagnosis of AOSD [ 23 ]. However, this study included fewer cases and did not analyze the relationship between ADA activity and disease activity.…”

Section: Discussionmentioning

confidence: 99%

Increased serum adenosine deaminase activity in patients with adult-onset Still's disease

Geng

Guo

et al. 2022

BMC Immunol

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Background Adult-onset Still's disease (AOSD) is a systemic inflammatory disease of unknown etiology, lacking specific diagnosis and disease activity evaluation indicators. This study will analyze the activity and clinical significance of Adenosine deaminase (ADA) in AOSD patients. Methods Totally 53 AOSD patients, 60 patients with other autoimmune diseases including systemic lupus erythematosus (SLE), sjogren syndrome (SS) and rheumatoid arthritis (RA), as well as 60 healthy subjects were included in this study. AOSD activity was determined by Pouchot score. We analyzed the correlation between ADA activity and clinical parameters. In addition, the correlation between ADA activity and disease activity score was also analyzed. Results This study showed that the activity of ADA in AOSD patients was significantly higher than that of healthy controls, SLE, SS and RA patient groups (p < 0.0001). The ADA activity of AOSD patients decreased significantly after systemic treatment (p < 0.0001). Correlation analysis showed that ADA activity was positively correlated with ALT(r = 0.54, p < 0.0001), AST (r = 0.82, p < 0.0001) and serum ferritin (r = 0.67, p < 0.001). ADA activity was negatively correlated with white blood cell (r = − 0.42, p = 0.002) and platelet counts (r = − 0.44, p = 0.001). We also found a significant positive correlation between the activity of ADA and Pouchot score in AOSD patients (r = 0.51, p = 0.001). Receiver operating characteristic (ROC) curve analysis showed that ADA activity had a sensitivity of 93.3%, and a specificity of 83% for the diagnosis of AOSD, with an area under the curve of 0.93. Conclusion This study showed that serum ADA activity can be used as a potential biomarker for AOSD diagnosis and disease activity assessment.

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“…In addition, a previous study showed elevated serum adenosine deaminase (ADA) levels may be associated with Still’s disease. 3 …”

Section: Introductionmentioning

confidence: 99%

“…In addition, a previous study showed elevated serum adenosine deaminase (ADA) levels may be associated with Still's disease. 3 It is diagnosed based on Yamaguchi criteria 4 after the exclusion of infections, malignancy, lymphoproliferative diseases, drug reactions, and other auto-inflammatory disorders.…”

Section: Introductionmentioning

confidence: 99%

Atypical Presentation of Adult-Onset Still’s Disease

Sobhrakhshankhah

Zamani

Behnam

et al. 2023

Middle East J Dig Dis

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Adult-onset Still’s disease (AOSD) is a rare rheumatic disorder with various presentations. It is diagnosed based on the Yamaguchi criteria, besides the exclusion of infectious diseases and other rheumatic disorders and malignancies. Here, we describe a case of a young man, presenting with remittent fever, abdominal pain, and persistent nausea. Further evaluations showed elevated acute phase reactants, abnormal levels of liver transaminase, multiple lymphadenopathies, and pleural effusion. He was finally diagnosed with AOSD and responded well to corticosteroids and methotrexate. We describe the present case to alert gastroenterologists to AOSD as a rare differential diagnosis in patients with persistent gastrointestinal symptoms.

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Potential role of adenosine deaminase in the diagnosis of adult-onset Still’s disease

Cited by 6 publications

References 14 publications

Relationship between serum adenosine deaminase levels and liver histology in autoimmune hepatitis

Relationship between serum adenosine deaminase levels and liver histology in autoimmune hepatitis

Increased serum adenosine deaminase activity in patients with adult-onset Still's disease

Atypical Presentation of Adult-Onset Still’s Disease

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