Potential risk factors for infection with Candida spp. in critically ill patients

Abstract

The incidence, risk factors and prognostic factors for candidal infection were determined in a prospective study of 280 infected patients. Thirty-one (11%) patients were infected with Candida spp., sub-divided into 18 (58%) with C. albicans, and 13 (42%) with non-albicans spp. (six C. glabrata, three C. parapsilosis, and one each of C. krusei, C. tropicalis, C. guilliermondii and C. lusitaniae). Infection with Candida spp. was always associated with concurrent bacterial infection. By univariate logistic regression analysis, the degree of morbidity and the duration of mechanical ventilation were independent predictive factors for death, but infection with Candida spp., was not. Factors associated with Candida spp. infection were the degree of morbidity, intensive care unit length of stay, alterations of immune response, and the number of medical devices involved. By multivariate logistic regression analysis, the only independent risk factor for candidal infection was intensive care unit length of stay.

Candida colonization and candidemia in a pediatric intensive care unit

“…This is similar to the pattern seen at our institute during 1993-2000 (8) but is in contrast to C. albicans being the most common Candida species elsewhere in NICUs (21) and adult ICUs in developed countries (29,31). In low birth weight infants, the majority of fugal colonization occurred with C. albicans followed by C. parapsilosis and C. tropicalis (21).…”

Occurrence of oral Candida colonization and its risk factors among patients with malignancies in China

“…The risk factors for oral Candida colonization and infection in immunosuppressed patients were complex [41], including local oral factors, such as low salivary flow rates and pH, smoking, wearing dentures, and poor oral hygiene [42,43], and other systemic factors such as patient age, disease types, treatment methods, and the physical performance of patients [44,45]. We found the colonization of Candida in patients with pulmonary cancer and digestive tract malignant tumor was significantly associated with age, which was the same as previous report [46].…”

Do clinical features allow for accurate prediction of fungal pathogenesis in bloodstream infections? Potential implications of the increasing prevalence of non-albicans candidemia

“…Past efforts have generally addressed risk factors for fungemia and for mortality in persons who develop fungemia (3,(12)(13)(14)(15)(16)(17)(18). Little attention, however, has focused on the epidemiology of candidemia outside the ICU or on factors identifying patients potentially infected with a nonalbicans isolate.…”