Occurrence of oral Candida colonization and its risk factors among patients with malignancies in China

Sun, Haiyan; Chen, Yong; Zou, Xuan; Li, Huan; Yin, Xiuyun; Qin, Haifeng; Liu, Rongrui; Yu, Chengbin; Li, Qihong; Yu, Kaitao; Han, Xiaonan; Zou, Jie; Cheng, Ge; Li, Han

doi:10.1007/s00784-015-1524-2

Cited by 18 publications

(25 citation statements)

References 47 publications

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“…Likewise, long‐term antibiotics use as a risk factor for Candida colonization is unclear (Fanello et al, ; Meurman et al, ). We did not find increased risk of Candida colonization in patients with history of antibiotics use as reported in a previous study in patients with cancer (Sun et al, ). This could be due to small numbers of subjects who took antibiotics in the month prior to this study.…”

Section: Discussionsupporting

confidence: 72%

“…The result is consistent with previous studies which reported 55%–100% Candida colonization in postradiotherapy cancer patients (de Freitas et al, ; Jain et al, ; Karbach et al, ; Thaweboon et al, ). The prevalence was considerably higher than previously reported 25.7%–55% Candida colonization in healthy population (Ergun et al, ; Lam‐Ubol et al, ; Meurman et al, ; Sun et al, ; Thanyasrisung et al, ).…”

Section: Discussioncontrasting

confidence: 56%

“…The use of antifungal drug to prevent candidiasis and as a risk factor for NACS colonization has been controversial (Meurman et al, ; Sun et al, ). Our results suggest that history of antifungal drug use does not affect overall Candida colonization in multivariate analysis, but significantly reduced colonization by C. albicans .…”

Section: Discussionmentioning

confidence: 99%

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Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients

et al. 2019

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Objectives To evaluate (a) oral colonization of Candida species, especially for non‐albicans Candida species (NACS), in xerostomic postradiotherapy head and neck cancer patients and (b) risk factors affecting their colonization. Materials and methods Subjective and objective dry mouth scores, stimulated salivary flow rates, pH and buffering capacity were measured in 72 xerostomic postradiotherapy head and neck cancer patients. Candida counts and species identification were performed using oral rinse samples cultured in Candida Chromagar, followed by polymerase chain reaction and API 20C AUX system. Results Candida colonization was observed in 87.5% of subjects, with 80.6% and 48.6% of study population colonized by C. albicans and NACS, respectively. NACS was associated with high objective dry mouth scores, denture use, and females (p = .006, .009, and .036, respectively). In addition, Candida glabrata was detected more in females (p = .018) and denture wearers (p = .026), while Candida tropicalis was associated with high objective dry mouth scores (p = .022) and females (p = .027). Quantity of Candida colonization correlated positively with objective dry mouth scores (r = 0.599, p < .001) and negatively with salivary flow rates (r = −0.258, p = .041) and pH (r = −0.290, p = .022). Conclusion NACS colonization was common in xerostomic head and neck cancer patients. Increased signs of dry mouth, female and dental prostheses may promote NACS colonization.

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Section: Discussionsupporting

confidence: 72%

Section: Discussioncontrasting

confidence: 56%

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Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients

et al. 2019

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“…This result could be explained by the fact that the patients in our study have more dental prosthesis; 59.4% of total patients had a dental prosthesis, while 75.7% patients who had Candida colonization had a dental prosthesis in our study. The contributing factors that facilitate Candida formation in dental prostheses are suggested as poor oral hygiene habits and insufficient cleaning of prosthesis and specifically natural affinity of the Candida strains to colonize on the acrylic material of the prosthesis . In our study, we could not find a relationship between oral hygiene and inflammation.…”

Section: Discussioncontrasting

confidence: 77%

Oral Candida Colonization as a Risk Factor for Chronic Inflammation and Atherosclerosis in Hemodialysis Patients

et al. 2019

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The purpose of this study was to determine the prevalence of oral Candida spp. in HD patients and to investigate its relation with systemic inflammation and atherosclerosis. Microbiological samples were taken from buccal mucosa, palate, and dental prosthesis with a cotton swab. High‐sensitivity CRP (hsCRP) and IL‐6 were measured as inflammation markers. A total of 69 patients (58% male and median age 62 years) were enrolled in this study; 53.6% of total patients had oral Candida colonization. HsCRP and IL‐6 levels were found to be significantly higher in the oral Candida colonization positive group than in the Candida colonization negative group (P = 0.002 and P = 0.01, respectively). HDL levels were significantly lower in the Candida colonization positive group (P = 0.03). Peripheral artery disease (P = 0.05) and oral Candida colonization (P = 0.002) were significantly associated with inflammation. In addition to conventional risk factors such as age (P = 0.03), diabetes (P = 0.001), and peripheral artery disease (P = 0.002), oral Candida colonization is associated with coronary artery disease (P = 0.04). Oral Candida colonization might be associated with chronic inflammation and development of atherosclerosis in HD patients.

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“…C. albicans was the most common species isolated from patients, accounting for 30.8% in patients with pulmonary cancer (n=78), 33.7% in patients with digestive tract malignant tumor (n=101), and 12.7% in patients with hematopoietic system tumor (n=79). Cancer patients are a high-risk population for Candida colonization (10).…”

Section: Introductionmentioning

confidence: 99%

Sensitization of Candida albicans to terbinafine by berberine and berberrubine

et al. 2016

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Abstract. Candida albicans (C. albicans) is an opportunistic fungal pathogen, particularly observed in immunocompromised patients. C. albicans accounts for 50-70% of cases of invasive candidiasis in the majority of clinical settings. Terbinafine, an allylamine antifungal drug, has been used to treat fungal infections previously. It has fungistatic activity against C. albicans. Traditional Chinese medicines can be used as complementary medicines to conventional drugs to treat a variety of ailments and diseases. Berberine is a quaternary alkaloid isolated from the traditional Chinese herb, Coptidis Rhizoma, while berberrubine is isolated from the medicinal plant Berberis vulgaris, but is also readily derived from berberine by pyrolysis. The present study demonstrates the possible complementary use of berberine and berberrubine with terbinafine against C. albicans. The experimental findings assume that the potential application of these alkaloids together with reduced dosage of the standard drug would enhance the resulting antifungal potency.

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Occurrence of oral Candida colonization and its risk factors among patients with malignancies in China

Abstract: Old aged patients with pulmonary cancer and digestive tract malignant tumor are high-risk population for Candida colonization. Increasing frequency of teeth brush might be helpful for preventing Candida colonization.

Cited by 18 publications

References 47 publications

Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients

Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients

Oral Candida Colonization as a Risk Factor for Chronic Inflammation and Atherosclerosis in Hemodialysis Patients

Sensitization of Candida albicans to terbinafine by berberine and berberrubine

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