Potential Probiotic Properties of Blautia producta Against Lipopolysaccharide-Induced Acute Liver Injury

Mao, Bingyong; Guo, Weiling; Liu, Xuemei; Cui, Shumao; Zhang, Qiuxiang; Zhao, Jianxin; Tang, Xin; Zhang, Hao

doi:10.1007/s12602-023-10044-y

Cited by 19 publications

(15 citation statements)

References 46 publications

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“…The genus Ruminococcaceae can increase the production of short-chain fatty acids (SCFAs), including acetic, propionic, and butyric acids, while reducing the release of inflammatory factors ( Wang et al, 2023 ). Additionally, Ruminiclostridium5 and Anaerotruncus have been linked to CD8+ and CD4+ T cells, and their abundance is negatively related to the levels of inflammatory TNF-α, IL-1β, and IL-6 ( Mao et al, 2023 ; Singh et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota and autoimmune neurologic disorders: a two-sample bidirectional Mendelian randomization study

Zhang,

Fang,

Zheng

et al. 2024

Front. Microbiol.

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BackgroundIncreasing evidence has suggested that alterations in the gut microbiome are correlated with autoimmune neurologic disorders, yet the causal relationship between them has yet to be established.MethodsFrom the published genome-wide association study (GWAS) summary statistics, we obtained data on the gut microbiota and three autoimmune neurologic disorders (Multiple Sclerosis, Guillain-Barré Syndrome, and Myasthenia Gravis). We then implemented a two-sample Mendelian Randomization (MR) to determine the causal relationship between the gut microbiota and the diseases. To validate the results, we conducted a series of sensitivity analyses. Finally, to verify the direction of causality, a reverse-causality analysis was done.ResultsWe discovered that a higher relative abundance of the genus Ruminococcus2 (OR: 1.213, 95% CI: 1.006–1.462, p = 0.043, PFDR = 0.048) and the genus Roseburia (OR: 1.255, 95% CI: 1.012–1.556, p = 0.038, PFDR = 0.048) were associated with a higher risk of MS. Furthermore, the higher the abundance of the class Mollicutes (OR: 3.016, 95% CI: 1.228–7.411, p = 0.016, PFDR = 0.021), the genus Eubacterium (hallii group) (OR: 2.787, 95% CI: 1.140–6.816, p = 0.025, PFDR = 0.025), and the phylum Tenericutes (OR: 3.016, 95% CI: 1.228–7.411, p = 0.016, PFDR = 0.021) was linked to a greater probability of GBS. Additionally, the higher the abundance of the genus Ruminococcaceae UCG005 (OR: 2.450, 95% CI: 1.072–5.598, p = 0.034, PFDR = 0.036), the genus Holdemania (OR: 2.437, 95% CI: 1.215–4.888, p = 0.012, PFDR = 0.024), genus Lachnoclostridium (OR: 3.681, 95% CI: 1.288–10.521, p = 0.015, PFDR = 0.025) and the genus Eubacterium (ruminantium group) (OR: 2.157, 95% CI: 1.211–3.843, p = 0.003, PFDR = 0.016) correlated with a greater chance of MG occurrence. No SNPs were identified as outliers through sensitivity analysis. Then, the results of the reverse MR analysis did not indicate any reverse causality.ConclusionOur findings demonstrate a causal relationship between the gut microbiota and three autoimmune neurologic disorders, providing novel insights into the mechanisms of these autoimmune neurologic disorders that are mediated by gut microbiota.

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Section: Discussionmentioning

confidence: 99%

Gut microbiota and autoimmune neurologic disorders: a two-sample bidirectional Mendelian randomization study

Zhang,

Fang,

Zheng

et al. 2024

Front. Microbiol.

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“…Similar to the above studies, the current study found that L. reuteri alleviated hepatic I/R-induced injury by a mechanism that may be related to the protection of intestinal barrier function and maintenance of gut microbiota homeostasis. Blautia , with potential probiotic properties, alleviates LPS-induced acute hepatic injury [ 32 ]. Lactobacillus acidophilus and Bifidobacterium may protect against myocardial ischemia-reperfusion [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus reuteri mitigates hepatic ischemia/reperfusion injury by modulating gut microbiota and metabolism through the Nrf2/HO-1 signaling

Zhang,

Gong,

Tan

et al. 2024

Biol Direct

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Background This study seeks to investigate the impacts of Lactobacillus reuteri (L. reuteri) on hepatic ischemia-reperfusion (I/R) injury and uncover the mechanisms involved. Methods Mice in the I/R groups were orally administered low and high doses of L.reuteri (L.reuteri-low and L. reuteri-hi; 1 × 1010 CFU/d and 1 × 1011 CFU/d), for 4 weeks prior to surgery. Following this, mice in the model group were treated with an Nrf2 inhibitor (ML-385), palmitoylcarnitine, or a combination of both. Results After treatment with L. reuteri, mice exhibited reduced levels of serum aminotransferase (ALT), aspartate aminotransferase (AST), and myeloperoxidase (MPO) activity, as well as a lower Suzuki score and apoptosis rate. L. reuteri effectively reversed the I/R-induced decrease in Bcl2 expression, and the significant increases in the levels of Bax, cleaved-Caspase3, p-p65/p65, p-IκB/IκB, p-p38/p38, p-JNK/JNK, and p-ERK/ERK. Furthermore, the administration of L. reuteri markedly reduced the inflammatory response and oxidative stress triggered by I/R. This treatment also facilitated the activation of the Nrf2/HO-1 pathway. L. reuteri effectively counteracted the decrease in levels of beneficial gut microbiota species (such as Blautia, Lachnospiraceae NK4A136, and Muribaculum) and metabolites (including palmitoylcarnitine) induced by I/R. Likewise, the introduction of exogenous palmitoylcarnitine demonstrated a beneficial impact in mitigating hepatic injury induced by I/R. However, when ML-385 was administered prior to palmitoylcarnitine treatment, the previously observed effects were reversed. Conclusion L. reuteri exerts protective effects against I/R-induced hepatic injury, and its mechanism may be related to the promotion of probiotic enrichment, differential metabolite homeostasis, and the Nrf2/HO-1 pathway, laying the foundation for future clinical applications.

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“…Several Blautia species have recently been identified to have beneficial effects on host function, including the suppression of Vibrio cholera colonization 48 , improving inflammatory responses in a DSS mouse model 49 , ameliorating obesity and type-2 diabetes 50 and protecting against enteric viral infection 51 , despite being a rather low-abundance gut bacterium. The molecular mechanism has not been identified in all cases, but SCFA production was shown to be an important factor for some of these observations.…”

Section: Discussionmentioning

confidence: 99%

The gut commensalBlautiamaintains colonic mucus function under low fiber consumption through short-chain fatty acid-mediated activation of Ffar2

Holmberg,

Feeney,

Prasoodanan P.K.

et al. 2023

Preprint

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Beneficial gut bacteria are indispensable for developing colonic mucus and fully establishing its protective function against intestinal microorganisms. Low-fiber diet consumption alters the gut bacterial configuration and disturbs this microbe-mucus interaction, but the specific bacteria and microbial metabolites responsible for maintaining mucus function remain poorly understood. By using human-to-mouse microbiota transplantation andex vivoanalysis of colonic mucus function, our proof-of-concept study demonstrates that individuals who increase their daily dietary fiber intake can improve the capacity of their gut microbiota to prevent diet-mediated mucus defects. Mucus growth, a critical feature of intact colonic mucus, correlated with the abundance of the gut commensalBlautia, and supplementation ofBlautia coccoidesto mice confirmed its mucus-stimulating capacity. Mechanistically,B. coccoidesstimulated mucus growth through the production of the short-chain fatty acids propionate and acetate via activation of the short-chain fatty acid receptor Ffar2, which could serve as a new target to restore mucus growth during mucus-associated lifestyle diseases.

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Potential Probiotic Properties of Blautia producta Against Lipopolysaccharide-Induced Acute Liver Injury

Cited by 19 publications

References 46 publications

Gut microbiota and autoimmune neurologic disorders: a two-sample bidirectional Mendelian randomization study

Gut microbiota and autoimmune neurologic disorders: a two-sample bidirectional Mendelian randomization study

Lactobacillus reuteri mitigates hepatic ischemia/reperfusion injury by modulating gut microbiota and metabolism through the Nrf2/HO-1 signaling

The gut commensalBlautiamaintains colonic mucus function under low fiber consumption through short-chain fatty acid-mediated activation of Ffar2

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