Potential Preventive Effect of Lactobacillus Acidophilus and Lactobacillus Plantarum in Patients With Polyps or Colorectal Câncer

Zinatizadeh, Nazi; Khalili, Farzad; Fallah, Parviz; Farid, Malihe; Geravand, Maryam; Yaslianifard, Somayeh

doi:10.1590/s0004-2803.201800000-87

Cited by 17 publications

(15 citation statements)

References 23 publications

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“…The study used 16 S rRNA to conduct preliminary gene detection on 77 samples of CRC, polyps, and healthy subjects, and used absolute realtime PCR to determine the copy number of bacteria per Gram of feces. The results confirmed that taking L. acidophilus and L. plantarum in people with a family history of CRC and patients with polyps may be a method to prevent, treat, or alleviate CRC (Zinatizadeh et al, 2018). In addition, Lactobacillus casei BL23, a probiotic-specific strain, can inhibit colitis-associated CRC, which can be used as a potential new strategy for the prevention and treatment of CRC.…”

Section: Probiotics Prebiotics Synbiotics and Postbioticssupporting

confidence: 61%

The Role of Intestinal Microbiota in Colorectal Cancer

Ren

Zhao

et al. 2021

Front. Pharmacol.

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Colorectal cancer is a multifactorial disease involving genetic, environmental, and lifestyle risk factors. Intestinal microbiota plays an important role in the occurrence and development of colorectal cancer. Studies have shown that the behavior of intestinal microbiota can lead to pathological changes in the host intestine, which can be divided into epigenetic changes and carcinogenic changes at the gene level, and ultimately promote the formation and development of colorectal cancer. Intestinal microbiota is mainly distributed in the intestinal epithelium, which is composed of a large number of microorganisms interacting with the host intestinal cells. It can affect the immune-inflammation and metabolism of the gastrointestinal tract, and may be used as a biomarker for disease diagnosis. Regulation of gut microbiota is a promising strategy for the prevention and treatment of colorectal cancer. This article reviews the role of intestinal microbiota in the development of colorectal cancer, including the related mechanisms of intestinal microbiota promoting colorectal cancer, the use of intestinal microbiota in the diagnosis of colorectal cancer, and the regulation of intestinal microbiota in the prevention or treatment of colorectal cancer.

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Section: Probiotics Prebiotics Synbiotics and Postbioticssupporting

confidence: 61%

The Role of Intestinal Microbiota in Colorectal Cancer

Ren

Zhao

et al. 2021

Front. Pharmacol.

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“…Since cancer is a multifactorial disease, any generalization of effective factors in the induction of cancer should be done with caution. In a study recently conducted by our research team to determine the role of Lactobacillus in inducing or preventing the spread of adenoma or colorectal cancer (26) , lactobacilli may could have a preventive role in the induction or spread of malignancy. The results of this study and our previous study (26) , indicate the dual role of bacteria in preventing or inducing malignancy.…”

Section: Real-time Quantification Pcr Of Total Enterococcus Faecalis mentioning

confidence: 99%

“…In a study recently conducted by our research team to determine the role of Lactobacillus in inducing or preventing the spread of adenoma or colorectal cancer (26) , lactobacilli may could have a preventive role in the induction or spread of malignancy. The results of this study and our previous study (26) , indicate the dual role of bacteria in preventing or inducing malignancy. These results could be an introduction to more extensive studies on the microbiome of colorectal cancer patients compared to healthy people to provide more clarity and broader scope to determine the role of bacteria in the health and illness of individuals.…”

Section: Real-time Quantification Pcr Of Total Enterococcus Faecalis mentioning

confidence: 99%

Investigation of Enterococcus Faecalis Population in Patients With Polyp and Colorectal Cancer in Comparison of Healthy Individuals

Geravand

Fallah

Yaghoobi

et al. 2019

Arq. Gastroenterol.

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BACKGROUND: Colorectal cancer is one of the most commonly diagnosed cancers around the world. One of the factors involved in the development of colorectal cancer is the changes in the normal flora of the intestine. OBJECTIVE: In this study, the mean copy number of Enterococcus faecalis in people with polyps and people with colorectal cancer has been evaluated in comparison with healthy controls. METHODS: In this study, 25 patients with colorectal cancer and 28 patients with intestinal polyps were selected and stool specimens were taken. In addition, 24 healthy individuals were selected as control group. Extraction of bacterial DNA from the stool sample were performed. The molecular methods of PCR for confirmation of standard strain and absolute Real Time PCR (qRT-PCR) method were used to evaluate the number of Enterococcus faecalis in the studied groups. RESULTS: The results of this study indicate that the mean copy number of Enterococcus faecalis in patients with colorectal cancer was 11.2x109 per gram of stool, and in patients with polyps was 9.4x108 per gram of stool. In healthy people, this number was 9x108 per gram of stool. There was a significant difference between the implicit copy numbers in the three groups. (P<0.05). CONCLUSION: Enterococcus faecalis in faecal flora of people with colorectal cancer was significantly higher than those with polyps and healthy people. This could potentially signify the ability of this bacterium to induce colorectal cancer. More studies are needed to prove this theory.

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“…As members of the gut microbiota, lactic acid bacteria (LAB), especially Lactobacillus, exert health bene ts for the host when administered in adequate amounts [13]. Several lines of evidence demonstrated that the supplementation of LAS could act as a prophylactic strategy for the prevention and cure of colorectal cancer as a result of their probiotic properties [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

The Inhibition of Proliferation and Invasion of Human Colon Carcinoma Cell Line (Caco-2 cells) by Cell-free Supernatants from Lactobacillus Rhamnosus and Lactobacillus Acidophilus

Shokati

Soleimani

Abroun

2021

Preprint

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Background: The epidemiological studies indicated that colorectal cancer is one of the most common types of cancer in the world and is considered a leading cause of cancer-related death. The present study aimed to investigate the inhibitory effect of lactobacillus acidophilus supernatant (LAS) and lactobacillus rhamnosus supernatant (LRS) on the growth and invasiveness of the human colon carcinoma cell line (Caco2) in-vitro. Methods: In this experimental study, the anti-proliferative activity and anti-invasion potential of LAS and LRS were determined by MTT and transwell chambers assays, respectively. The expression of mitochondrial membrane potential-9 (MMP-9) and matrix metalloproteinase-12 (MMP12) genes were analyzed by real-time PCR.Results: The results indicated that supernatants of these two lactobacilli had cytotoxic effects on Caco-2 cells at a concentration of 25% v/v and higher. Thus, the minimum concentrations (25% V/V) of supernatants were chosen for further experiments. LAS and LRS could significantly suppress the invasiveness of Caco-2 cells. Also, the expression of MMP12 was significantly increased in Caco-2 cells when treated with LAS, whereas LRS had no significant effect on the invasive capacity and the gene expression levels of MMP12. The expression of MMP-9 was statistically decreased in Caco2 cells treated with LAS and LRS (P<0.00001).Conclusion: In general, it was shown that LAS and LRS exert anti-cancer activity against the growth, invasion, and metastasis of Caco2 cells in-vitro. It seems that these two bacteria could be used as prophylactic and therapeutic agents for the prevention and treatment of colorectal cancer.

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Potential Preventive Effect of Lactobacillus Acidophilus and Lactobacillus Plantarum in Patients With Polyps or Colorectal Câncer

Cited by 17 publications

References 23 publications

The Role of Intestinal Microbiota in Colorectal Cancer

The Role of Intestinal Microbiota in Colorectal Cancer

Investigation of Enterococcus Faecalis Population in Patients With Polyp and Colorectal Cancer in Comparison of Healthy Individuals

The Inhibition of Proliferation and Invasion of Human Colon Carcinoma Cell Line (Caco-2 cells) by Cell-free Supernatants from Lactobacillus Rhamnosus and Lactobacillus Acidophilus

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