Potential Presymptomatic Transmission of SARS-CoV-2, Zhejiang Province, China, 2020

Abstract

et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet.

Epidemiological parameters of coronavirus disease 2019: a pooled analysis of publicly reported individual data of 1155 cases from seven countries

“…These findings are in line with those of previous studies. 8,9,[14][15][16][17] Stratified analysis in this study found a trend towards longer incubation period of less severe cases as compared with that of more severe cases. This implies that severe cases could be detected and 'removed' from the pool of transmission sources more quickly, while less severe cases would All rights reserved.…”

“…For example, in some studies, most cases had a long or even unclear interval of exposure, making it difficult to determine the exact exposure date 3,5,13 and giving rise to error. Besides, the order of transmission (i.e., who is infector and who is infectee) in clustering cases, which is crucial to estimation of both parameters, is easy to be mistaken given the possibility of pre-symptomatic and asymptomatic transmission, [14][15][16][17] but previous studies rarely described how this issue was handled.…”

Epidemiology of 2019 novel coronavirus in Jiangsu Province, China after wartime control measures: A population-level retrospective study

“…This result indicated that SARS-CoV-2 was transmitted in Jiangsu Province, and the second-generation transmitted cases appeared. The epidemiology of human infections with SARS-CoV-2 in Jiangsu was also found in other areas outside Hubei Province [12,13]. A few cases were confirmed whether residents or travelers to Hubei Province or close contacts.…”

Clinical characteristics and diagnostic challenges of pediatric COVID-19: A systematic review and meta-analysis

“…Some reports have already demonstrated that asymptomatic infections in children occurred in family clusters. 35,37,38 Because of the high asymptomatic ratio, pediatric COVID-19 cases are usually detected by contact tracing. Unfortunately, presymptomatic or asymptomatic transmission of SARS-CoV-2 has been reported.…”

“…Unfortunately, presymptomatic or asymptomatic transmission of SARS-CoV-2 has been reported. 38,39 The transmission of SARS-CoV-2 via asymptomatic children is reasonable. To date, no clustering or asymptomatic transmission among children has been documented.…”