Clinical characteristics and diagnostic challenges of pediatric COVID-19: A systematic review and meta-analysis

Chang, Tu‐Hsuan; Wu, Jhong-Lin; Chang, Luan‐Yin

doi:10.1016/j.jfma.2020.04.007

Cited by 217 publications

(324 citation statements)

References 34 publications

(35 reference statements)

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“…After removing duplicates, the first search yielded eight systematic reviews 5,8‐14 . Three of them were eliminated because they did include information on clinical characteristics in children 8‐10 .…”

Section: Resultsmentioning

confidence: 99%

“…Three of them were eliminated because they did include information on clinical characteristics in children 8‐10 . Therefore, we evaluated five systematic reviews done at different periods during the pandemic and thus including somewhat different primary studies 11‐14 . Castagnoli et al 11 included 18 articles, 17 from China and one from Singapore (444 patients < 10 years old and 553 aged 10‐19 years), published up to 3 March 2020.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Asthma and COVID‐19 in children: A systematic review and call for data

Castro-Rodriguez

Forno

2020

Pediatric Pulmonology

108

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Rationale Whether asthma constitutes a risk factor for coronavirus disease‐2019 (COVID‐19) is unclear. Here, we aimed to assess whether asthma, the most common chronic disease in children, is associated with higher COVID‐19 risk or severity in pediatric populations. Methods We performed a systematic literature search in three stages: first, we reviewed PubMed, EMBASE, and CINAHL for systematic reviews of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and COVID‐19 in pediatric populations, and reviewed their primary articles; second, we searched PubMed for studies on COVID‐19 or SARS‐CoV‐2 and asthma/wheeze, and evaluated whether the resulting studies included pediatric populations; third, we repeated the second search in http://BioRxiv.org and http://MedRxiv.org to find pre‐prints that may have information on pediatric asthma. Results In the first search, eight systematic reviews were found, of which five were done in pediatric populations; none of the 67 primary studies included data on pediatric asthma as a comorbidity for COVID‐19. In the second search, we found 34 results in PubMed, of which five reported asthma in adults, but none included data on children. In the third search, 25 pre‐prints in MedRxiv included data on asthma, but none on children. We found one report by the US Centers for Disease Control and Prevention stating that 40/345 (~11.5%) children with data on chronic conditions had “chronic lung diseases including asthma,” and one from a tertiary hospital in New York that reported asthma in 11/46 (~23.9%) children hospitalized for COVID‐19. Conclusion There is scarcely any data on whether childhood asthma (or other pediatric respiratory diseases) constitute risk factors for SARS‐CoV‐2 infection or COVID‐19 severity. Studies are needed that go beyond counting the number of cases in the pediatric age range.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Asthma and COVID‐19 in children: A systematic review and call for data

Castro-Rodriguez

Forno

2020

Pediatric Pulmonology

108

View full text Add to dashboard Cite

show abstract

“…After removing duplicates, the first search yielded eight systematic reviews [5,[7][8][9][10][11][12][13]. Three of them were eliminated because they did include information on clinical characteristics in children [7][8][9].…”

Section: Resultsmentioning

confidence: 99%

“…Three of them were eliminated because they did include information on clinical characteristics in children [7][8][9]. Therefore, we evaluated five systematic reviews done at different periods during the pandemic and thus including somewhat different primary studies [10][11][12][13] [13] included 45 studies from China (the total number of patients was not described) up to March 19, 2020. And Streng et al [14] included 8 studies from China (ranging from 6 to 2,143 patients) and one survey from Germany (33 patients) in hospitalized children, up to March 31, 2020.…”

Section: Resultsmentioning

confidence: 99%

Asthma and COVID-19 in children – a systematic review and call for data

Castro-Rodriguez

Forno

2020

Preprint

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Rationale:Whether asthma constitutes a risk factor for COVID-19 is unclear. Methods:We performed a systematic literature search in three stages: First, we reviewed PubMed, EMBASE and CINAHL for systematic reviews of SARS-CoC-2 and COVID-19 in pediatric populations, and reviewed their primary articles; next, we searched PubMed for studies on COVID-19 or SARS-CoV-2 and asthma/wheeze, and evaluated whether the resulting studies included pediatric populations; lastly, we repeated the second search in BioRxiv.org and MedRxiv.org to find pre-prints that may have information on pediatric asthma. Results:In the first search, eight systematic reviews were found, of which five were done in pediatric population; after reviewing 67 primary studies we found no data on pediatric asthma as a comorbidity for COVID-19. In the second search, we found 25 results in PubMed, of which five reported asthma in adults, but none included data on children. In the third search, 14 preprints in MedRxiv were identified with data on asthma, but again none with pediatric data. We found only one report by the U.S. CDC stating that 40/345 (~11.5%) children with data on chronic conditions had "chronic lung diseases including asthma". Conclusion:There is scarcely any data on whether childhood asthma (or other pediatric respiratory diseases) constitute risk factors for SARS-CoV-2 infection or COVID-19 severity. Studies are needed that go beyond counting the number of cases in the pediatric age range.

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“…However, the accessibility to health care facility and some factors that could modify clinical features (e.g pregnancy, co-morbidities of individuals) were not taken in to account. The studies primarily on paediatric and neonatal population were identi ed but not included in this analysis and suggest the need of a different study for that [45][46][47][48][49] .…”

Section: Discussionmentioning

confidence: 99%

Symptomatology of Coronavirus Disease 2019 (COVID-19) - Lessons from A Meta-Analysis Across 13 Countries

Gamakaranage

Hettiarachchi

Ediriweera

et al. 2020

Preprint

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Abstract Background: COVID-19 pandemic has resulted in varying clinical manifestations and mortality rates. There is no consensus on the symptomatology that would guide researchers and clinicians.Objective: The objective of the study was to identify symptoms and their frequencies of coronavirus disease 2019 with a meta-analysis of studies from several countries. Data sources: A systematic review using PubMed and Google Scholar data sources and reference tracing were used to identify 7176 relevant articles. Eligibility criteria: Suitable articles were selected manually with selection criteria and 14 original articles included for meta-analysis. Data abstraction analysis: PRISMA guideline was used for abstracting data. Then a table was generated by feeding it with numbers and proportions of each symptom described in original studies. A meta-analysis was carried out using random effect models on each symptom separately across the studies and their prevalence rates and 95% confident intervals calculated.Results: We identified 14 relevant scientific papers, either cross-sectional or cohort studies and analyzed. There were 2,660 cases of COVID-19. he majority were from China (n=2,439, 91.7%) and remainder from the Netherlands, Italy, Korea and India and one article from Europe. There was a total of 32 symptoms (i.e. present in >50% of patients): fever (79.56%, 95% CI: 72.17-86.09%), malaise (63.3%, 95% CI: 53.1 – 73.0%), cough (56.7. %, 95% CI: 48.6 - 64.6 %) and cold (55.6%, 95% CI: 45.2 – 65.7%). Symptoms of intermediate incidence (5-49%) were; anosmia, sneezing, ocular pain, fatigue, sputum production, arthralgia, tachypnea, palpitation, headache, chest tightness, shortness of breath, chills, myalgia, sore throat, anorexia, weakness, diarrhea, rhinorrhea, dizziness, nausea, altered level of consciousness, vomiting and abdominal pain. Rare symptoms (<5% of patients) were: tonsil swelling, haemoptysis, conjunctival injection, lymphadenopathy and rash were uncommon symptoms of coronavirus disease (<5%).Conclusion and implications of key findings: We found (25/32) symptoms to be present in =>5% of cases which could be considered as “typical” symptoms of COVID-19. The list of symptoms we identified are different from those documents released by the WHO, CDC, NHS, Chinese CDC, Institute Pasteur and Mayo Clinic. The compiled list would be useful for future researchers to document a comprehensive picture of the illness.

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Clinical characteristics and diagnostic challenges of pediatric COVID-19: A systematic review and meta-analysis

Cited by 217 publications

References 34 publications

Asthma and COVID‐19 in children: A systematic review and call for data

Asthma and COVID‐19 in children: A systematic review and call for data

Asthma and COVID-19 in children – a systematic review and call for data

Symptomatology of Coronavirus Disease 2019 (COVID-19) - Lessons from A Meta-Analysis Across 13 Countries

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