Potential phytochemicals in the fight against skin cancer: Current landscape and future perspectives

Iqbal, Javed; Abbasi, Banzeer Ahsan; Ahmad, Riaz; Batool, Riffat; Mahmood, Tariq; Ali, Barkat; Khalil, Ali Talha; Kanwal, Sobia; Shah, Sayed Afzal; Alam, Muhammad Maqsood; Bashir, Sheeza; Badshah, Hussain; Munir, Akhtar

doi:10.1016/j.biopha.2018.10.107

Cited by 76 publications

(45 citation statements)

References 157 publications

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“…DLS is performed to confirm the size of NPs in colloid suspension in the range of nano and submicron, and its ZP measurement is based on particles movement under electric field. Cancer is a fatal disease, a major cause of deaths around the globe, and is continuously increasing in cause of death by an estimated~21 million by the year 2030 [30,49,50]. Among the numerous types of cancers, liver cancer is presently the second deadliest cancer in males and sixth in female causes (~745,517) deaths.…”

Section: Biosynthesis Of Znonpsmentioning

confidence: 99%

Bioactivities of Geranium wallichianum Leaf Extracts Conjugated with Zinc Oxide Nanoparticles

et al. 2019

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This study attempts to obtain and test the bioactivities of leaf extracts from a medicinal plant, Geranium wallichianum (GW), when conjugated with zinc oxide nanoparticles (ZnONPs). The integrity of leaf extract-conjugated ZnONPs (GW-ZnONPs) was confirmed using various techniques, including Ultraviolet–visible spectroscopy, X-Ray Diffraction, Fourier Transform Infrared Spectroscopy, energy-dispersive spectra (EDS), scanning electron microscopy, transmission electron microscopy, and Raman spectroscopy. The size of ZnONPs was approximately 18 nm, which was determined by TEM analysis. Additionally, the energy-dispersive spectra (EDS) revealed that NPs have zinc in its pure form. Bioactivities of GW-ZnONPs including antimicrobial potentials, cytotoxicity, antioxidative capacities, inhibition potentials against α-amylase, and protein kinases, as well as biocompatibility were intensively tested and confirmed. Altogether, the results revealed that GW-ZnONPs are non-toxic, biocompatible, and have considerable potential in biological applications.

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Section: Biosynthesis Of Znonpsmentioning

confidence: 99%

Bioactivities of Geranium wallichianum Leaf Extracts Conjugated with Zinc Oxide Nanoparticles

et al. 2019

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“…They are natural antioxidants, elevating the levels of antioxidant enzymes, CDKs, cyclins, p53, p21, and Bax. Moreover, they scavenge ROS, and decrease various molecular targets including EGFR, Notch-1, ERK, MAPK, NF-kB, STAT, β-catenin, PI3K, AKt, and mTOR [ 153 , 161 , 228 ]. Dietary phytochemicals can also inhibit the proliferation of established skin cancer cells by arresting the cell cycle, preventing metastasis and angiogenesis, suppressing EMT, regulating epigenetic alterations, and downregulating MMPs and COX-2 enzymes.…”

Section: Discussionmentioning

confidence: 99%

“…I3C is a widely distributed member of the Cruciferae family that includes Brussels sprouts, broccoli, and cauliflower [ 153 ]. I3C has been reported to show activity against prostate, breast, and lung cancer [ 69 , 154 , 155 , 156 ] Sarkar et al reported that IC3 (60 μmol/L) and its in vivo dimeric product 3,3′-diindolylmethane (30 μmol/L) showed anticancer potential in prostate cancer cell lines through the regulation of cell cycle, cell proliferation, cell death, and transcriptional activities.…”

Section: Dietary Phytochemicals For Skin Cancer Therapymentioning

confidence: 99%

An Update on the Role of Dietary Phytochemicals in Human Skin Cancer: New Insights into Molecular Mechanisms

et al. 2020

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Human skin is continuously subjected to environmental stresses, as well as extrinsic and intrinsic noxious agents. Although skin adopts various molecular mechanisms to maintain homeostasis, excessive and repeated stresses can overwhelm these systems, leading to serious cutaneous damage, including both melanoma and non-melanoma skin cancers. Phytochemicals present in the diet possess the desirable effects of protecting the skin from damaging free radicals as well as other benefits. Dietary phytochemicals appear to be effective in preventing skin cancer and are inexpensive, widely available, and well tolerated. Multiple in vitro and in vivo studies have demonstrated the significant anti-inflammatory, antioxidant, and anti-angiogenic characteristics of dietary phytochemicals against skin malignancy. Moreover, dietary phytochemicals affect multiple important cellular processes including cell cycle, angiogenesis, and metastasis to control skin cancer progression. Herein, we discuss the advantages of key dietary phytochemicals in whole fruits and vegetables, their bioavailability, and underlying molecular mechanisms for preventing skin cancer. Current challenges and future prospects for research are also reviewed. To date, most of the chemoprevention investigations have been conducted preclinically, and additional clinical trials are required to conform and validate the preclinical results in humans.

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“…Initially identified as an SIRT1 activator which regulates energy homeostasis and mitochondrial biogenesis within cells, it is now studied for its apoptosis promoting capacity by enhancing sensitivity to tumor necrosis factor-α and suppressing NF-κB activation [ 104 , 106 , 107 ]. In skin cancer applications, studies have shown that topical administration of resveratrol not only improved skin elasticity, hydration, and luminosity [ 108 ], but also provided protection against UV radiations and UV-induced carcinogenesis by regulating protein activity regarding apoptosis, decreasing reactive oxygen species production, inhibiting tumor incidence and tumorigenesis, and modulating cell cycle molecules and cell signaling pathways [ 109 ]. Additionally, it has proved its potential to initiate senescence in squamous cells carcinoma cells through its autolysosome form blockade and Rictor protein expression downregulation, which altered cancer cell skeleton and suppressed cancer progression [ 110 ].…”

Section: Natural Anti-cancer Agents For Skin Cancermentioning

confidence: 99%

Regenerative Wound Dressings for Skin Cancer

Pavel

Chircov

Rădulescu

et al. 2020

Cancers

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Skin cancer is considered the most prevalent cancer type globally, with a continuously increasing prevalence and mortality growth rate. Additionally, the high risk of recurrence makes skin cancer treatment among the most expensive of all cancers, with average costs estimated to double within 5 years. Although tumor excision is the most effective approach among the available strategies, surgical interventions could be disfiguring, requiring additional skin grafts for covering the defects. In this context, post-surgery management should involve the application of wound dressings for promoting skin regeneration and preventing tumor recurrence and microbial infections, which still represents a considerable clinical challenge. Therefore, this paper aims to provide an up-to-date overview regarding the current status of regenerative wound dressings for skin cancer therapy. Specifically, the recent discoveries in natural biocompounds as anti-cancer agents for skin cancer treatment and the most intensively studied biomaterials for bioactive wound dressing development will be described.

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Potential phytochemicals in the fight against skin cancer: Current landscape and future perspectives

Cited by 76 publications

References 157 publications

Bioactivities of Geranium wallichianum Leaf Extracts Conjugated with Zinc Oxide Nanoparticles

Bioactivities of Geranium wallichianum Leaf Extracts Conjugated with Zinc Oxide Nanoparticles

An Update on the Role of Dietary Phytochemicals in Human Skin Cancer: New Insights into Molecular Mechanisms

Regenerative Wound Dressings for Skin Cancer

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