Potential pancreatic lipase inhibitory activity of an endophytic<i>Penicillium</i>species

Gupta, Mahiti; Saxena, Sanjai; Goyal, Dinesh

doi:10.3109/14756366.2013.871007

Cited by 23 publications

(19 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this context, we chose to evaluate both the anti-obesity and antidiabetic property of the in vitro raised Stevia plant. The study was focussed on inhibition of two enzymes, viz., pancreatic lipase and α-amylase for anti-obesity and antidiabetic property, respectively [1,4]. The lipase inhibitory property of the methanolic extract of in vitro raised Stevia plant (IC 50 =5.74 µg/ml) in this study was found to be much better than that observed in Stevia (IC 50 =530 µg/ml) [21].…”

Section: Discussionmentioning

confidence: 75%

“…In vitro pancreatic lipase inhibitory activity was evaluated using a slight modified protocol described by Gupta et al [1]. Varying concentrations…”

Section: Dose Response Activity Of Methanolic Extract Of Stevia Againmentioning

confidence: 99%

“…Obesity is a daunting health problem which occurs due to an imbalance between calorie uptake and utilization. Today obesity is becoming the major cause of preventable deaths, both in developed and developing nations [1]. It has been reported by World Health Organization (WHO) that every third individual around the globe is obese.…”

Section: Introductionmentioning

confidence: 99%

“…Hence, inhibiting the action of α-amylase is the best way to control diabetes [4]. The current armamentarium of drugs available for the treatment of obesity suffers from various unwanted effects including fecal urgency, oily stools, abdominal cramps, flatulence, and oozing of oil from the anus leading to oily spotting [1]. Thus, there is an utmost requirement for exploring alternate avenues for development of new drugs for the treatment of these diseases with less or no side effects.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Biological Activities of Novel in Vitro Raised Stevia Plant

Sharma

Meshram

Gupta

2017

Asian J Pharm Clin Res

Self Cite

View full text Add to dashboard Cite

Objective: This communication explores a lead fraction from methanolic extract of novel Stevia species raised under in vitro conditions for its various biological activities.Methods: The dried Stevia leaves were crushed in methanol to get the polar extract. This methanol extract was tested for pancreatic lipase and alpha-amylase inhibitory activity using quantitative plate assays. Antibacterial property of the extract was also evaluated against Staphylococcus epidermidis, Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa. Further, the antioxidant potential was evaluated using 1,1-diphenyl-2-picrylhydrazyl.Results: The methanolic extract inhibited pancreatic lipase with IC50 of 5.74 μg/ml in a similar manner to a well-known anti-obesity drug in the market orlistat. The methanolic extract also showed a better pancreatic α-amylase inhibitory activity (IC50=88 μg/ml) than acarbose. Further, the lead fraction exhibited 88.48% antioxidant activity. It also exhibited broad spectrum antimicrobial activity against the spectrum of Gram-positive and Gram-negative bacteria tested under laboratory conditions with a minimal inhibitory concentration ranging from 1.95 to 31.25 μg/ml.Conclusion: Thus, this study signifies the vast potential of the lead fraction from a novel Stevia species for further development into a herbal formulation for prevention of various infectious and non-infectious diseases.

show abstract

Section: Discussionmentioning

confidence: 75%

“…In vitro pancreatic lipase inhibitory activity was evaluated using a slight modified protocol described by Gupta et al [1]. Varying concentrations…”

Section: Dose Response Activity Of Methanolic Extract Of Stevia Againmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biological Activities of Novel in Vitro Raised Stevia Plant

Sharma

Meshram

Gupta

2017

Asian J Pharm Clin Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Mahiti Gupta [20] Pancreatic lipase (PL) is considered as one of the safest target for dietinduced anti-obesity drug development. Orlistat is the only PL inhibitor approved for antiobesity treatment till date.…”

Section: World Journal Of Pharmacy and Pharmaceutical Sciencesmentioning

confidence: 99%

Inhibitory Activity of Chalcone Moeties on Pancreatic Lipase Enzyme: A Review

Palayyan¹

2017

WJPPS

View full text Add to dashboard Cite

The main challenge of today's research is to design a novel drug for the treatment of ailments with lesser side effects. Obesity derives from Latin word obesities which means tout, fat, or plump. Medically, obesity is a condition in which excess body fat has been accumulated to the extent that it may have an adverse effect on health, leading to reduced life expectancy or increased health problems. Improper lipid metabolism adds other disorders like diabetes, musculoskeletal, cardiovascular and leads to cancer. Improper balance between energy intake and energy expenditure leads to obesity. The major target for the development of antiobesity drug is to inhibit the action of pancreatic lipase enzyme. Chalcones and their heterocyclic analogues, belong to the flavanoid family, which possess a number of interesting biological properties such as antioxidant, cytotoxic, anticancer, antimicrobial, antiprotozoal, antiulcer, antihistaminic and anti-inflammatory activities. In this review, an attempt is made to present a current scenario of the bioactive compounds from chalcone moieties possessing diverse electron-donating and -withdrawing groups were prepared that have been investigated for their pancreatic lipase inhibition. The purpose of this review is to provide an overview of the inhibitory activity of naturally occurring and synthetic chalcones on pancreatic lipase enzyme.

show abstract

Endophytes: Potential Source of Therapeutically Important Secondary Metabolites of Plant Origin

Mohammed

Patil

et al. 2017

Endophytes: Crop Productivity and Protection

View full text Add to dashboard Cite

Potential pancreatic lipase inhibitory activity of an endophyticPenicilliumspecies

Cited by 23 publications

References 21 publications

Biological Activities of Novel in Vitro Raised Stevia Plant

Biological Activities of Novel in Vitro Raised Stevia Plant

Inhibitory Activity of Chalcone Moeties on Pancreatic Lipase Enzyme: A Review

Endophytes: Potential Source of Therapeutically Important Secondary Metabolites of Plant Origin

Contact Info

Product

Resources

About