Potential of trace elements as supplements for the metabolic control of Type 2 Diabetes Mellitus: A systematic review

The protective effect of zinc, selenium, and chromium on myocardial fibrosis in the offspring of rats with gestational diabetes mellitus

“…Consistent with these findings, two systematic reviews also concluded that zinc, selenium, and chromium could improve glycemic and lipid profiles. 32,33 Hyperglycemia and dyslipidemia have been shown to contribute to diabetic cardiomyopathy. Therefore, the amelioration of zinc, selenium, and chromium on metabolic dysfunction may be a potential approach for protecting the GDM offspring from cardiac damage.…”

Joint associations among non-essential heavy metal mixtures and nutritional factors on glucose metabolism indexes in US adults: evidence from the NHANES 2011–2016

“…16 Previous research has indicated that incorporating trace elements into one's diet could serve as an alternative approach for managing T2DM, and has the potential to alter the inflammatory profile. 17 Investigating the combined impact of nutrients and non-essential heavy metals on glucose metabolism is a crucial research priority due to the high probability of co-exposure, overlapping mechanisms of action, the potential for beneficial nutrients to counteract the adverse effects of non-essential heavy metals, and the non-existence of options for environmental exposure. However, such research is still limited.…”

The Effects of Dietary Chromium Supplementation along with Discontinuing a High-Fat Diet on the Microbial Enzymatic Activity and the Production of SCFAs in the Faeces of Rats

“…Indeed, numerous studies point to major concerns about the effectiveness of Cr supplementation in the treatment of obesity and its related ailments; however, the authors do not rule out small positive health effects [ 23 , 24 ]. To understand the role of chromium in the treatment of diabetes and other metabolic syndrome constituents, these discrepancies warrant further extensive studies [ 25 ]. Doubts about the effectiveness of dietary Cr-picolinate are pushing researchers to look for alternative forms of supplemental chromium [ 26 , 27 ].…”