Potential of PVA-doped bacterial nano-cellulose tubular composites for artificial blood vessels

Tang, Jingyu; Bao, Luhan; Li, Xue; Chen, Lin; Hong, Feng

doi:10.1039/c5tb01144b

Cited by 88 publications

(51 citation statements)

References 46 publications

(65 reference statements)

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“…The impregnation of PVA into BC tubes (as skeleton base material) significantly improved the properties of composite tubes, especially mechanical and water permeability [160]. Gonzalez …”

Section: Nanocellulosementioning

confidence: 99%

PVA-based hydrogels for tissue engineering: A review

Kumar

Han

2016

International Journal of Polymeric Materials and Polymeric Biom

341

150

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Poly (vinyl alcohol) (PVA) is a hydrophilic polymer with excellent biocompatibility and has been applied in various biomedical areas due to its favorable properties. PVA-based hydrogels have been recognized as promising biomaterials and suitable candidate for tissue engineering applications and can be manipulated to act various critical roles.However, due to some disadvantages (i.e., lack of cell-adhesive property), it needs further modification for desired and targeted applications. This review highlights recent progress in the design and fabrication of PVA-based hydrogels, including cross-linking and processing techniques. Finally, major challenges and future perspectives in tissue engineering are briefly discussed. GRAPHICAL ABSTRACTDownloaded by [University of Sussex Library] at 08:36 28 June 2016 2

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“…The impregnation of PVA into BC tubes (as skeleton base material) significantly improved the properties of composite tubes, especially mechanical and water permeability [160]. Gonzalez …”

Section: Nanocellulosementioning

confidence: 99%

PVA-based hydrogels for tissue engineering: A review

Kumar

Han

2016

International Journal of Polymeric Materials and Polymeric Biom

341

150

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“…This involves the generation of tissue‐engineered blood vessels (TEBV) that can be used for in vitro aneurysm models as well as in vivo treatment. Recent studies have indicated bacterial nanocellulose (BNC) hydrogel composite as a promising material for artificial blood vessels, which have improved mechanical properties and water permeability . However, there are two important limitations of this technology: (1) the limited regenerative capacity of autogenous blood vessel cells and (2) the ability to create TEBV with the necessary bursting strength term related with the resistance to rupture .…”

Section: Introductionmentioning

confidence: 99%

Bacterial Nanocellulose Magnetically Functionalized for Neuro‐Endovascular Treatment

Echeverry‐Rendón

Reece

Pastrana

et al. 2017

Macromolecular Bioscience

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Current treatments for brain aneurysms are invasive, traumatic, and not suitable in most patients with increased risks. A new alternative method is using scaffold stents to create a local and focal attraction force of cells for an in situ reconstruction of the tunica media. For this purpose, a nanostructured bioactive coating is designed to render an asymmetric region of the stent scaffold magnetic and biomimetic, which utilizes bacterial nanocellulose (BNC) as a platform for both magnetic and cell attraction as well as proliferation. The magnetization of the BNC is realized through the reaction of Fe III and II, precipitating superparamagnetic iron oxide nanoparticles (SPION). Subsequently, magnetic bacterial nanocellulose (MBNC) is coated with polyethylene glycol to improve its biocompatibility. Cytotoxicity and biocompatibility are evaluated using porcine aortic smooth muscle cells. Preliminary cellular migration assays demonstrate the behavior between MBNC and cells labeled with SPION. In this work, (1) synthesis of BNC impregnated with magnetic nanoparticles is successfully demonstrated; (2) a viable, resilient, and biocompatible hydrogel membrane is tested for neuroendovascular application using a stent scaffold; (3) cell viability and minimal cytotoxicity is achieved; (4) cell migration tests and examination of cellular magnetic attraction confirm the viability of MBNC as a multifunctional coating.

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“…Bacterial nanocellulose, a kind of cellulose secreted at the air–liquid interface of culture media by some microorganisms (for example, Gluconacetobacter xylinus ), has been researched as a small blood vessel substitute for its excellent properties such as stability over a wide range of temperatures and pH levels, high purity and super water‐holding capacity, good mechanical properties and biocompatibility, ultrafine nanofiber network and high porosity . Researchers have found that the endotoxin in BNC can easily be eliminated to satisfy the requirement of FDA for implants in contact with blood (<20 EU per medical device) by using a purification method with sodium hydroxide treatment followed by water washing .…”

Section: Introductionmentioning

confidence: 99%

Comparison of two types of bioreactors for synthesis of bacterial nanocellulose tubes as potential medical prostheses including artificial blood vessels

Tang

Bao

et al. 2016

J of Chemical Tech & Biotech

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BACKGROUND Bacterial nanocellulose (BNC) has prospects for use in applications of artificial blood vessels, esophagus and urethra. Several bioreactors have been utilized for synthesis of BNC tubes, however, little is known about differences in biosynthesis processes and tube properties. The current work for the first time compared two types of bioreactors, double‐silicone‐tube (D‐BNC) and single‐silicone‐tube (S‐BNC) bioreactors, to evaluate differences in preparation and properties of BNC tubes using fructose or glucose of 50 g L−1 and 100 g L−1, respectively. RESULTS The two bioreactors showed different biosynthesis processes of BNC tube production. The D‐BNC bioreactor provided higher yields and better mechanical performance of tubes because of the greater oxygen supply. Higher fructose concentration resulted in increased production of D‐BNC, but sugar types and concentrations had little effect on S‐BNC yields. Fructose granted stronger mechanical properties, but lower water permeability. Both types of tubes prepared with 100 g L−1 fructose were composed of porous nano‐fibrillar networks but showed different cross‐sectional morphologies and fiber distributions. CONCLUSION This study revealed the biosynthesis processes of BNC tubes in two bioreactors and their correlation with properties. The results suggest how to regulate BNC tubes with particular structures and properties for biomedical prostheses including artificial blood vessels. © 2016 Society of Chemical Industry

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Potential of PVA-doped bacterial nano-cellulose tubular composites for artificial blood vessels

Abstract: Introduction of PVA can improve the compliance of bacterial nano-cellulose hydrogel, which has been suggested as a promising biomaterial for artificial blood vessels especially for small-caliber vessels.

Cited by 88 publications

References 46 publications

PVA-based hydrogels for tissue engineering: A review

PVA-based hydrogels for tissue engineering: A review

Bacterial Nanocellulose Magnetically Functionalized for Neuro‐Endovascular Treatment

Comparison of two types of bioreactors for synthesis of bacterial nanocellulose tubes as potential medical prostheses including artificial blood vessels

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