Potential of natural bioactive C-glycosyl flavones for antidiabetic properties

Chua, Lee Suan; Abdullah, Farah Izana; Awang, Mohd Azrie

doi:10.1016/b978-0-12-817903-1.00008-5

Cited by 10 publications

(10 citation statements)

References 97 publications

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“…The naturally occurring Cglycosides of flavones from several plant species have been documented and their potential for anti-diabetic properties, rationalized. [68] In the absence of in vivo data, the antidiabetic effects of flavonoid C-glycosides on type 2 diabetes are presumed due to the inhibition of advanced glycation end products (AGEs) and digestive enzymes, stimulation of glycogen storage, and activation of insulin signaling. Vitexin 63 and isovitexin 60 isolated from mung beans (Vigna radiata) at100 mM inhibited glucose-and methylglyoxal-induced AGEs formation.…”

Section: Chalcones Dihydrochalcones and Flavanonesmentioning

confidence: 99%

“…C ‐glycosides are proven to have higher hydrolytic stability compared to O ‐glycosides, higher resistivity to degradation, and their presence in the dietary intake, not restricted to cereals, has thus inspired studies towards therapeutic applications. The naturally occurring C ‐glycosides of flavones from several plant species have been documented and their potential for anti‐diabetic properties, rationalized [68] . In the absence of in vivo data, the antidiabetic effects of flavonoid C ‐glycosides on type 2 diabetes are presumed due to the inhibition of advanced glycation end products (AGEs) and digestive enzymes, stimulation of glycogen storage, and activation of insulin signaling.…”

Section: Flavones/isoflavones/flavonols/flavanolsmentioning

confidence: 99%

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The Emerging Promise with O/C‐Glycosides of Important Dietary Phenolic Compounds

2022

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Section: Chalcones Dihydrochalcones and Flavanonesmentioning

confidence: 99%

Section: Flavones/isoflavones/flavonols/flavanolsmentioning

confidence: 99%

The Emerging Promise with O/C‐Glycosides of Important Dietary Phenolic Compounds

2022

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“…The total terpenoid content of crude extract and individual fractions from each plant variety was estimated according to the method described by Chua et al [16]. An aliquot of 250 µL (1 mg/mL) of sample was mixed with 250 µL vanillin (8 g/100 mL ethanol) and then added with 2.5 mL of sulfuric acid (72 %).…”

Section: Total Terpenoid Contentmentioning

confidence: 99%

Comparing Three Varieties of Labisia pumila (Primulaceae): Phytochemicals and Antioxidation

Chua

Abdullah²,

Salleh³

2022

Trends Sci

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Labisia pumila is a traditional medicinal herb that is widely used by women to firm the uterus after childbirth. Recent scientific studies have also proven its pharmacological importance. However, the comparison of phytochemicals in the different varieties of the herb is very limited in literature. Therefore, 3 common varieties of L. pumila leaves were extracted in a reflux system, and consequently the crude extract was fractionated using reversed phase solid phase extraction (SPE) into individual fractions according to solvent polarity. L. pumila var. alata (LPA) showed the highest yield of crude extract and total phenolics content which was also in line with high DPPH radical scavenging activity. While, L. pumila var. pumila with red leaves (LPPR) exhibited higher total flavonoids and triterpenoids than its green leaves counterpart (LPPG). Higher antioxidant capacity was possibly due to the presence of plant co-pigments in LPPR. Glycosylated flavones including orientin were putatively detected in the intermediate polar fraction of LPA based on mass fragments. However, 0 % methanol (polar) and 100 % methanol (less polar) fractions notably contained compounds competing oxygen with nitric oxide radicals from the formation of nitrite ions. Proton NMR spectral analysis proposed N-[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(morpholin-4-yl)propan-2-yl]decanamide and 4-[({1,3-bis[(2-ethylpenta-3,4-dien-1-yl)oxy]propan-2-yl}oxy)methyl]hexa-1,2-diene in the 0 % methanol and 100 % methanol fractions, respectively. This study concluded that the plant variety of alata was more antioxidative than pumila. The detection of orientin and its derivatives are first time reported in LPA. Glycosylated flavones are more likely to be hydrogen atom and/or electron donors contributing to the major antioxidant property of the herb. HIGHLIGHTS pumila var. alata (LPA) and L. pumila var. pumila (LPP) are two commonly used varieties LPA showed to have higher phenolics, but LPP had higher flavonoids and terpenoids content LPA exhibited higher antioxidant capacity because of higher phenolics content Many glycosylated flavones, especially orientin found in 50 % methanol fraction of LPA HPLC, tandem mass spectrometry and proton NMR discovered new phytochemicals in LPA GRAPHICAL ABSTRACT

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“…Flavones in the form of C-glycoside, demonstrate an important role in plants, including as an antioxidant and pigment for UV absorption. In addition, flavones are also used to regulate the interaction of plants with microbes and insects in defense of the plants [25]. Flavones are non-essential nutrient compounds that provide additional nutraceutical effects in food [26].…”

Section: Flavonesmentioning

confidence: 99%

Flavonoids as Antidiabetic Agents

Cahyana

Adiyanti

2021

Indones. J. Chem.

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Flavonoids are polyphenol compounds that exert many potential health benefits, including diabetes type-II, which is the third most common disease that causes death, right after cancer and cardiovascular diseases. The excessively high level of blood glucose has been believed to trigger type II diabetes. The aim of this review is to describe the flavonoid's ability as an alternative treatment for diabetes type-II patients. This paper addresses several aspects in which flavonoids may impart a pivotal role in starch digestion, such as the interaction of flavonoids with enzymes involved in starch hydrolysis, the role of flavonoids in inhibiting glucose absorption, as well as the interaction of flavonoids with starch to form a complex resistant to hydrolysis. Further studies, however, are suggested to extensively carry out, particularly the ones dealing with the intervention study using human volunteers to reveal the role of flavonoids in the real applications. The data on human intervention studies are still rare and can further be exploited using meta-analysis to have firmer results. Flavonoids in the food matrix are more realistic to perform to reveal the effect of interaction with other compounds, which may affect the mechanism of flavonoids interaction or their bioavailability.

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Potential of natural bioactive C-glycosyl flavones for antidiabetic properties

Cited by 10 publications

References 97 publications

The Emerging Promise with O/C‐Glycosides of Important Dietary Phenolic Compounds

The Emerging Promise with O/C‐Glycosides of Important Dietary Phenolic Compounds

Comparing Three Varieties of Labisia pumila (Primulaceae): Phytochemicals and Antioxidation

Flavonoids as Antidiabetic Agents

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