The Emerging Promise with O/C‐Glycosides of Important Dietary Phenolic Compounds

Aidhen, Indrapal Singh; Srikanth, Sriranjani; Lal, H. B.

doi:10.1002/ejoc.202200758

Eur J Org Chem

2022

DOI: 10.1002/ejoc.202200758

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The Emerging Promise with O/C‐Glycosides of Important Dietary Phenolic Compounds

Indrapal Singh Aidhen

Sriranjani Srikanth

H. B. Lal

Abstract: This review presents a brief overview of important dietary phenolics and their biological properties for severing as a lead in ongoing research for their applications in therapeutics.

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2024

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Synthesis of C-Glucoside Analogues of Naturally Occurring Phenylethanoid O-Glucosides

Aidhen,

Subramanyam,

Sumit

2024

SynOpen

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Structural modifications of natural products has been a highly effective approach in the search for new leads with improved biological activity, aqueous solubility, and stability. Phenylethanoid glycosides (PEGs), as natural compounds, have attracted great attention due to their promising biological activities. These activities include neuroprotection, antioxidant, immunoregulation, anti-inflammatory, and analgesic effects, as well as antitumor, antiviral, and hepatoprotective abilities. Three potent PEGs, acteoside, echinacoside, and salidroside, are gaining renewed interest in this class of compounds. However, being O-glycosides, PEGs have low bioavailability due to factors such as poor intestinal permeability and low hydrolytic stability. The promising pharmacological properties and the limitations have inspired us to synthesize C-analogues that are expected to be hydrolytically stable.

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Synthesis of C-Glucoside Analogues of Naturally Occurring Phenylethanoid O-Glucosides

Aidhen,

Subramanyam,

Sumit

2024

SynOpen

View full text Add to dashboard Cite

show abstract

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The Emerging Promise with O/C‐Glycosides of Important Dietary Phenolic Compounds

Abstract: This review presents a brief overview of important dietary phenolics and their biological properties for severing as a lead in ongoing research for their applications in therapeutics.

Cited by 1 publication

References 253 publications

Synthesis of C-Glucoside Analogues of Naturally Occurring Phenylethanoid O-Glucosides

Synthesis of C-Glucoside Analogues of Naturally Occurring Phenylethanoid O-Glucosides

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The Emerging Promise with O/C‐Glycosides of Important Dietary Phenolic Compounds

Abstract: This review presents a brief overview of important dietary phenolics and their biological properties for severing as a lead in ongoing research for their applications in therapeutics.

Cited by 1 publication

References 253 publications

Synthesis of C-Glucoside Analogues of Naturally Occurring Phenyl­ethanoid O-Glucosides

Synthesis of C-Glucoside Analogues of Naturally Occurring Phenyl­ethanoid O-Glucosides

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Synthesis of C-Glucoside Analogues of Naturally Occurring Phenylethanoid O-Glucosides

Synthesis of C-Glucoside Analogues of Naturally Occurring Phenylethanoid O-Glucosides