Potential of nano-phytochemicals in cervical cancer therapy

Yadav, Neera; Parveen, Shama; Banerjee, Monisha

doi:10.1016/j.cca.2020.01.035

Cited by 53 publications

(21 citation statements)

References 153 publications

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“…High-risk HPV infection is the main cause of cervical cancer [3,4]. Although great strides have been made in the diagnostic methods and treatment strategies of cervical cancer, the overall survival rate of the patients remains unsatisfactory partially due to its late detection and recurrence [5,6]. Hence, it is of great necessity to illuminate the underlying molecular mechanisms of cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

NR2F2-AS1 accelerates cell proliferation through regulating miR-4429/MBD1 axis in cervical cancer

et al. 2020

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Cervical cancer is one of the most frequent malignant tumors in female. Increasing studies have demonstrated that long noncoding RNAs (lncRNAs) play a key role in the development of multiple cancers. Although some studies have confirmed that lncRNA NR2F2 antisense RNA 1 (NR2F2-AS1) is a pro-cancer gene in many cancers, the molecular mechanism of NR2F2-AS1 in cervical cancer has not been completely elucidated. In the present study, our results revealed that NR2F2-AS1 expression was up-regulated in cervical cancer tissues and cells, notably in patients with advanced cervical cancer. NR2F2-AS1 accelerated progression of cervical cancer by facilitating cell proliferation, migration, invasion, and EMT process, but inhibiting cell apoptosis. Moreover, NR2F2-AS1 acted as a molecular sponge of miR-4429 and methyl-CpG-binding domain protein 1 (MBD1) was a downstream target of miR-4429 in cervical cancer. Furthermore, there was a negative correlation between miR-4429 expression and NR2F2-AS1 or MBD1 expression in tumor tissues. Rescue experiments confirmed that MBD1 overexpression partly rescued NR2F2-AS1 knockdown-mediated inhibition of progression in cervical cancer. To sum up, these results suggested the potential mechanism of NR2F2-AS1 in cervical cancer and revealed that NR2F2-AS1 exerted its carcinogenic effect via regulating miR-4429/MBD1 axis, indicating a promising insight into the therapeutic target of cervical cancer.

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Section: Introductionmentioning

confidence: 99%

NR2F2-AS1 accelerates cell proliferation through regulating miR-4429/MBD1 axis in cervical cancer

et al. 2020

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“…Thus, the development of novel formulations (nanosuspensions, solid lipid nanoparticles, liposomes, gold nanoparticles, polymeric nanoparticles) with a better bioavailability, activity, stability and pharmacokinetics is underway in order to improve the efficacy of these compounds [ 358 ]. The use of these novel formulations facilitates the intracellular uptake of the polyphenol and reduces its toxicity and clearance rate [ 359 ]. Accordingly, clinical trials evaluating the efficacy of polyphenols, novel formulations, and their combination with conventional therapies are ongoing for the treatment of patients with different types of cancer [ 360 , 361 , 362 , 363 , 364 , 365 , 366 ].…”

Section: Discussionmentioning

confidence: 99%

Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies

Benvenuto

Albonici

Focaccetti

et al. 2020

IJMS

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One of the hallmarks of cellular transformation is the altered mechanism of cell death. There are three main types of cell death, characterized by different morphological and biochemical features, namely apoptosis (type I), autophagic cell death (type II) and necrosis (type III). Autophagy, or self-eating, is a tightly regulated process involved in stress responses, and it is a lysosomal degradation process. The role of autophagy in cancer is controversial and has been associated with both the induction and the inhibition of tumor growth. Autophagy can exert tumor suppression through the degradation of oncogenic proteins, suppression of inflammation, chronic tissue damage and ultimately by preventing mutations and genetic instability. On the other hand, tumor cells activate autophagy for survival in cellular stress conditions. Thus, autophagy modulation could represent a promising therapeutic strategy for cancer. Several studies have shown that polyphenols, natural compounds found in foods and beverages of plant origin, can efficiently modulate autophagy in several types of cancer. In this review, we summarize the current knowledge on the effects of polyphenols on autophagy, highlighting the conceptual benefits or drawbacks and subtle cell-specific effects of polyphenols for envisioning future therapies employing polyphenols as chemoadjuvants.

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“…Chemotherapy remains a standard approach to treat cervical cancer. However, the efficiency of conventional chemotherapeutic drugs is limited by their undesirable and severe side effects, lack of specificity, rapid in vivo degradation, poor biodistribution, suboptimal concentrations and intervals between treatments [ 15 ]. Common cervical cancer chemotherapeutic drugs include cisplatin, paclitaxel and methotrexate.…”

Section: Nanomedicinementioning

confidence: 99%

“…The ability of chitosan and methoxypolyethylene glycol-coated nanoparticles were seen to effectively deliver methotrexate both in vivo and in vitro and to reduce HeLa cell proliferation [ 103 ]. Although polyphenols are promising anti-cervical cancer agents, their clinical application is hindered by their poor solubility and low oral bioavailability [ 15 ].…”

Section: Nanomedicinementioning

confidence: 99%

“…Nanotechnology has the potential to overcome these limitations, by increasing the selectivity and potency of chemical, physical and biological approaches for eliciting cancer cell death whilst minimising collateral toxicity to non-malignant cells [ 12 , 13 ]. The favourable and unique properties of nanoparticles can improve the delivery of therapeutics, thereby enhancing their activity in cervical cancer cells whilst reducing harmful side effects in healthy cells [ 14 , 15 ]. Hence, this meta-analysis aims to review the potential of nanomedicine in the improvement of cervical cancer therapeutics, especially in developing countries.…”

Section: Introductionmentioning

confidence: 99%

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Cervical cancer: a meta-analysis, therapy and future of nanomedicine

Venkatas

Singh

2020

ecancer

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Cervical cancer is one of the leading causes of female death, with an annual mortality rate exceeding 200,000 in developing communities. Despite the past decade bearing witness to a reduction in cervical cancer cases throughout developed countries, the prevalence in developing countries continues to rapidly rise. The increase in cervical cancer cases is attributed to the lack of financial resources and the unavoidable risk factors of the disease. Traditional means of anticancer therapy are compromised by reduced drug potency, non-specificity, negative side effects and the development of multiple drug resistance (MDR), which leads to a decrease in the long-term anticancer therapeutic efficacy. Recent advances in nanomedicine have elucidated the potential of nanoparticles to reduce the side effects and improve the survival rate of patients, by enhancing selective delivery and uptake of photosensitive, therapeutic and genetic material to cervical cancer cells, thereby enhancing antitumour efficiency. This review paper analyses the risk factors and epidemiology of cervical cancer globally, especially in developing communities, whilst demonstrating the enhanced anticancer treatment using selected nanoparticles.

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Potential of nano-phytochemicals in cervical cancer therapy

Cited by 53 publications

References 153 publications

NR2F2-AS1 accelerates cell proliferation through regulating miR-4429/MBD1 axis in cervical cancer

NR2F2-AS1 accelerates cell proliferation through regulating miR-4429/MBD1 axis in cervical cancer

Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies

Cervical cancer: a meta-analysis, therapy and future of nanomedicine

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