Potential of laser‐induced fluorescence‐light detection and ranging for future stand‐off virus surveillance

Abstract

Viruses remain a significant public health concern worldwide. Recently, humanity has faced deadly viral infections, including Zika, Ebola and the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The threat is associated with the ability of the viruses to mutate frequently and adapt to different hosts. Thus, there is the need for robust detection and classification of emerging virus strains to ensure that humanity is prepared in terms of vaccine and drug developments. A point or stand-off biosensor that can detect and classify viruses from indoor and outdoor environments would be suited for viral surveillance. Light detection and ranging (LiDAR) is a facile and versatile tool that has been explored for stand-off detection in different environments including atmospheric, oceans and forest sensing. Notably, laser-induced fluorescence-light detection and ranging (LIF-LiDAR) has been used to identify MS2 bacteriophage on artificially contaminated surgical equipment or released amidst other primary biological aerosol particles in laboratory-like close chamber. It has also been shown to distinguish between different picornaviruses. Currently, the potentials of the LIF-LiDAR technology for real-time stand-off surveillance of pathogenic viruses in indoor and outdoor environments have not been assessed. Considering the increasing applications of LIF-LiDAR for potential microbial pathogens detection and classification, and the need for more robust tools for viral surveillance at safe distance, we critically evaluate the prospects and challenges of LIF-LiDAR technology for real-time stand-off detection and classification of potentially pathogenic viruses in various environments.

Perspectives of Photonics Technology to Diagnosis COVID–19 Viruses: A Short Review

“…LiDAR systems are used to identify and characterize biogenic materials, for example, pathogenic bacteria in both laboratory and field environments [22]. A study of the Laser-induced fluorescence-light detection and ranging (LIF-LiDAR) technique has shown that it can be used for detection, real-time monitoring, and classification of viruses in various environments [23]. A significant benefit of the LIF-LiDAR is the long-range detection of dangerous bio-aerosols, particularly those classified as biological weapons.…”

Green-synthesized silver nanoparticle coating on paper for antibacterial and antiviral applications

“…Although a number of studies have focused on green synthesis of AgNPs for various applications, particularly antibacterial activities, little information is found on antiviral activities and other properties. At present, considering that microbial pathogens such as viruses are also a major public health concern [ 28 ], the development of coating materials for the inhibition of microorganism growth could be a new and effective approach to prevent bacterial and viral infection [ 29 , 30 ].…”

Advances in quantifying microbial contamination in potable water: Potential of fluorescence‐based sensor technology

“…While E. coli remains a robust indicator of fecal contamination, fluorescence is providing alternative approaches to monitoring which are not just limited to E. coli and BOD as considered in this review. The potential to use fluorescence for virus monitoring has yet to be explored in detail, although there has been some exploratory work in this area (Alimova et al, 2007; Owoicho et al, 2021).…”