Potential of ivermectin as an active ingredient of the attractive toxic sugar baits against the Indian malaria vectors <i>Anopheles culicifacies</i> and <i>Anopheles stephensi</i>

Kumar, Gaurav; Pasi, Shweta; Yadav, Chander Prakash; Kaur, Jaspreet; Sharma, Amit

doi:10.1002/ps.7217

Cited by 4 publications

(3 citation statements)

References 30 publications

(68 reference statements)

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“…New methods for malaria vector control should be considered for implementation in Hainan, as some studies in other countries have indicated there are methods that can significantly reduce mosquito populations. These were included: (1) attractive toxic sugar baits, which exploit the need for both male and female mosquitoes to take sugar meals [ 91 , 92 ]; (2) new insecticides such as broflanilide applied for IRS [ 93 , 94 , 95 ]; and (3) treating cattle with ivermectin to reduce the mosquito population in certain areas [ 96 ].…”

Section: Discussionmentioning

confidence: 99%

Surveillance and Control of Malaria Vectors in Hainan Province, China from 1950 to 2021: A Retrospective Review

et al. 2023

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Malaria is a serious mosquito-borne tropical disease impacting populations in tropical regions across the world. Malaria was previously hyperendemic in Hainan Province. Due to large-scale anti-malarial intervention, malaria elimination in the province was achieved in 2019. This paper reviews the literature on the ecology, bionomics, and control of malaria vectors in Hainan from 1951 to 2021. We searched PubMed, and the China national knowledge infrastructure (CNKI) database for relevant articles published and included three other important books published in Chinese or English in order to summarize research on species, distribution, vectorial capacity, ecology, the resistance of malaria vectors to insecticides, and malaria vector control in Hainan Province. A total of 239 references were identified, 79 of which met the criteria for inclusion in our review. A total of six references dealt with the salivary gland infection of Anophelines, six with vectorial capacity, 41 with mosquito species and distribution, seven with seasonality, three with blood preference, four with nocturnal activity, two with flight distance, 13 with resistance to insecticides, and 14 with vector control. Only 16 published papers met the criteria of addressing malaria vectors in Hainan over the last 10 years (2012–2021). Anopheles dirus and Anopheles minimus are primary malaria vectors, mainly distributed in the southern and central areas of Hainan. Indoor residual spraying with DDT and the use of ITNs with pyrethroid insecticides were the main interventions taken for malaria control. Previous studies on ecology, bionomics, and resistance of vectors provided scientific evidence for optimizing malaria vector control and contributed to malaria elimination in Hainan Province. We hope our study will contribute to preventing malaria reestablishment caused by imported malaria in Hainan. Research on malaria vectors should be updated to provide scientific evidence for malaria vector control strategies post-elimination as the ecology, bionomics, and resistance of vectors to insecticides may change with changes in the environment.

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Section: Discussionmentioning

confidence: 99%

Surveillance and Control of Malaria Vectors in Hainan Province, China from 1950 to 2021: A Retrospective Review

et al. 2023

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“…Tafenoquine with a companion point-of-care diagnostic device for quantitative assessment of G 6 PD deficiency can be adopted by the national programme after regulatory approvals in selected vivax-predominant areas. Novel vector control tools like Attractive Toxic Sugar Bait (ATSB) and ivermectin [32][33][34] can be used to circumvent the issue of emerging insecticide resistance to synthetic pyrethroids [25].…”

Section: Plos Global Public Healthmentioning

confidence: 99%

Tracking district-level performance in the context of achieving zero indigenous case status by 2027

Yadav

Hussain²,

Gupta³

et al. 2023

PLOS Glob Public Health

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India has committed to zero indigenous malaria cases by 2027 and elimination by 2030. Of 28 states and 8 union territories of India, eleven states were targeted to reach the elimination phase by 2020. However, state-level epidemiology indicates that several states of India may not be on the optimum track, and few goals set in National Framework for Malaria Elimination (NFME) for 2020 remain to be addressed. Therefore, tracking the current progress of malaria elimination in India at the district level, and identifying districts that are off track is important in understanding possible shortfalls to malaria elimination. Annual malaria case data from 2017–20 of 686 districts of India were obtained from the National Center for Vector-Borne Diseases Control (NCVBDC) and analysed to evaluate the performance of districts to achieve zero case status by 2027. A district’s performance was evaluated by calculating the annual percentage change in the total number of malaria cases for the years 2018, 2019 and 2020 considering the previous year as a base year. The mean, median and maximum of these annual changes were then used to project the number of malaria cases in 2027. Based on these, districts were classified into four groups: 1) districts that are expected to reach zero case status by 2027, 2) districts that would achieve zero case status between 2028 and 2030, 3) districts that would arrive at zero case status after 2030, and 4) districts where malaria cases are on the rise. Analysis suggest, a cohort of fifteen districts require urgent modification or improvement in their malaria control strategies by identifying foci of infection and customizing interventions. They may also require new interventional tools that are being developed recently so that malaria case reduction over the years may be increased.

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“…Today, ivermectin is used to treat a wide range of nematode infections in humans, including onchocerciasis, strongyloidiasis, loiasis, ascariasis, filariasis, cutaneous larva migrans, gnathostomiasis and trichuriasis, and arthropod infestations caused by Sarcoptes scabiei, Demodex, and Pediculosis [1]. Ivermectin is currently being evaluated and under extensive study in clinical trials for its potential use in treating mosquito-borne parasitic infections and as a complementary strategy for reduction through mass drug administration [20][21][22][23][24]. Although its antiparasitic effects are well documented, the anti-inflammatory activity of ivermectin has recently been uncovered [25].…”

Section: Introductionmentioning

confidence: 99%

Ivermectin: A Multifaceted Drug With a Potential Beyond Anti-parasitic Therapy

Kaur,

Blavo,

Parmar

2024

Cureus

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Ivermectin was first discovered in the 1970s by Japanese microbiologist Satoshi Omura and Irish parasitologist William C. Campbell. Ivermectin has become a versatile pharmaceutical over the past 50 years. Ivermectin is a derivative of avermectin originally used to treat parasitic infections. Emerging literature has suggested that its role goes beyond this and may help treat inflammatory conditions, viral infections, and cancers. Ivermectin's anti-parasitic, anti-inflammatory, anti-viral, and anticancer effects were explored. Its traditional mechanism of action in parasitic diseases, such as scabies and malaria, rests on its ability to interfere with the glutamate-gated chloride channels in invertebrates and the lack of P-glycoprotein in many parasites. More recently, it has been discovered that the ability of ivermectin to block the nuclear factor kappa-light-chain enhancer of the activated B (NF-κB) pathway that modulates the expression and production of proinflammatory cytokines is implicated in its role as an anti-inflammatory agent to treat rosacea. Ivermectin has also been evaluated for treating infections caused by viruses, such as SARS-CoV-2 and adenoviruses, through inhibition of viral protein transportation and acting on the importin α/β1 interface. It has also been suggested that ivermectin can inhibit the proliferation of tumorigenic cells through various pathways that lead to the management of certain cancers. The review aimed to evaluate its multifaceted effects and potential clinical applications beyond its traditional use as an anthelmintic agent.

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Potential of ivermectin as an active ingredient of the attractive toxic sugar baits against the Indian malaria vectors Anopheles culicifacies and Anopheles stephensi

Cited by 4 publications

References 30 publications

Surveillance and Control of Malaria Vectors in Hainan Province, China from 1950 to 2021: A Retrospective Review

Surveillance and Control of Malaria Vectors in Hainan Province, China from 1950 to 2021: A Retrospective Review

Tracking district-level performance in the context of achieving zero indigenous case status by 2027

Ivermectin: A Multifaceted Drug With a Potential Beyond Anti-parasitic Therapy

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