Potential of growth factor incorporated mesoporous bioactive glass for in vivo bone regeneration

Lalzawmliana, V.; Anand, Akrity; Kumar, Vinod; Das, Piyali; Devi, K. Bavya; Mukherjee, Jayanta; Maji, Asit Kumar; Kundu, Biswanath; Roy, Mousumi; Nandi, Samit Kumar

doi:10.1016/j.jmbbm.2018.12.012

Cited by 16 publications

(7 citation statements)

References 69 publications

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“…This is related to the migration of some ions such as HPO 4 3− Cl − , OH − , and CO 3 2− from SBF to the glass surfaces, as confirmed by MP‐AES analysis of SBF after soaking of glasses (discussed below). The same results were also observed for mineral‐derived mesoporous bioactive glasses 27 . However, weight loss in the glasses in the present study was greater than in the reported mesoporous glasses due to the release of more Si ions.…”

Section: Resultssupporting

confidence: 89%

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Bioactive calcium silicate glass synthesized from sustainable biomass wastes

Punj

Singh

2020

Biofuels Bioprod Bioref

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Biomass wastes of corn, sugarcane, and eggshells were used as resources to synthesize calcium silicate glass by applying the melt quench technique. The glasses were characterized by different experimental techniques to check their suitability as bioproducts. The in vitro bioactive properties of the glasses were evaluated in simulated body fluid (SBF). As confirmed by X-ray diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy, a carbonated amorphous hydroxyapatite layer was formed on the surface of the glass. The ions released from the glasses into SBF were analyzed by microwave plasma atomic emission spectroscopy. The dissolution rate of the glass increased with increasing proportion of eggshell powder in it. The Ca/P molar ratio for all the glasses was in the range of 1.78 to 4.1. These bioactive glasses formed carbonated amorphous hydroxyapatite, which can be used to enhance the osteointegration rate in the human body. Bio-food wastes are a sustainable, environmentfriendly and cost-effective source for the synthesis of different types of bioproducts.

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Section: Resultssupporting

confidence: 89%

“…The same results were also observed for mineral-derived mesoporous bioactive glasses. 27 However, weight loss in the glasses in the present study was greater than in the reported mesoporous glasses due to the release of more Si ions. It could be associated with the presence of trace elements in glasses that modify the silica glass network.…”

Section: −contrasting

confidence: 70%

Bioactive calcium silicate glass synthesized from sustainable biomass wastes

Punj

Singh

2020

Biofuels Bioprod Bioref

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“…For instance, MBGs with a high surface area to volume ratio exhibit superior bioactive behavior and better in vivo osteogenesis as compared to conventional glasses [ 100 , 101 ]. Additionally, MBGs can be loaded with different types of biomolecules (e.g., growth factors) and provide a drug delivery system for accelerating tissue repair and regeneration [ 102 ].…”

Section: Mesoporous Bioactive Glasses (Mbgs) As Platforms For the Del...mentioning

confidence: 99%

Antioxidant Effects of Bioactive Glasses (BGs) and Their Significance in Tissue Engineering Strategies

et al. 2022

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Elevated levels of oxidative stress are usually observed following injuries, leading to impaired tissue repair due to oxidation-related chronic inflammation. Several attempts have been made to manage this unfavorable situation, and the use of biomaterials with antioxidant activity is showing great promise in tissue engineering and regenerative medicine approaches. Bioactive glasses (BGs) are a versatile group of inorganic substances that exhibit an outstanding regenerative capacity for both hard and soft damaged tissues. The chemical composition of BGs provides a great opportunity for imparting specific biological activities to them. On this point, BGs may easily become antioxidant substances through simple physicochemical modifications. For example, particular antioxidant elements (mostly cerium (Ce)) can be added to the basic composition of the glasses. On the other hand, grafting natural antioxidant substances (e.g., polyphenols) on the BG surface is feasible for making antioxidant substitutes with promising results in vitro. Mesoporous BGs (MBGs) were demonstrated to have unique merits compared with melt-derived BGs since they make it possible to load antioxidants and deliver them to the desired locations. However, there are actually limited in vivo experimental studies on the capability of modified BGs for scavenging free radicals (e.g., reactive oxygen species (ROS)). Therefore, more research is required to determine the actual potential of BGs in decreasing oxidative stress and subsequently improving tissue repair and regeneration. The present work aims to highlight the potential of different types of BGs in modulating oxidative stress and subsequently improving tissue healing.

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“…For example, Lee J.-H. et al (2017) reported a significant enhancement in osteoblast activity, secretion of ECM molecules and calcification through the controlled release of phenamil (a drug known as a potent BMP signaling activator) and strontium ions from mesoporous bioglass nanoparticles. In recent proofof-concept in vivo studies, others have demonstrated how mesoporous nanobioglasses can also be an ideal delivery system for growth factors, such as IGF (Lalzawmliana et al, 2019) or FGF (Kang et al, 2015), with significantly imporved regenerative outcomes in preclinical animal models.…”

Section: Nanostructured Bio-glassesmentioning

confidence: 99%

Nanostructured Biomaterials for Bone Regeneration

Lyons

Plantz

Hsu

et al. 2020

Front. Bioeng. Biotechnol.

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This review article addresses the various aspects of nano-biomaterials used in or being pursued for the purpose of promoting bone regeneration. In the last decade, significant growth in the fields of polymer sciences, nanotechnology, and biotechnology has resulted in the development of new nano-biomaterials. These are extensively explored as drug delivery carriers and as implantable devices. At the interface of nanomaterials and biological systems, the organic and synthetic worlds have merged over the past two decades, forming a new scientific field incorporating nano-material design for biological applications. For this field to evolve, there is a need to understand the dynamic forces and molecular components that shape these interactions and influence function, while also considering safety. While there is still much to learn about the bio-physicochemical interactions at the interface, we are at a point where pockets of accumulated knowledge can provide a conceptual framework to guide further exploration and inform future product development. This review is intended as a resource for academics, scientists, and physicians working in the field of orthopedics and bone repair.

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Potential of growth factor incorporated mesoporous bioactive glass for in vivo bone regeneration

Cited by 16 publications

References 69 publications

Bioactive calcium silicate glass synthesized from sustainable biomass wastes

Bioactive calcium silicate glass synthesized from sustainable biomass wastes

Antioxidant Effects of Bioactive Glasses (BGs) and Their Significance in Tissue Engineering Strategies

Nanostructured Biomaterials for Bone Regeneration

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