Potential of flavonoids as anti-Alzheimer’s agents: bench to bedside

Kaur, Rajwinder; Sood, Ankita; Lang, Damanpreet Kaur; Bhatia, Saurabh; Al‐Harrasi, Ahmed; Aleya, Lotfi; Behl, Tapan

doi:10.1007/s11356-021-18165-z

Cited by 23 publications

(17 citation statements)

References 143 publications

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“…This was in line with the result that DG‐SDH (3:2) had the most flavonoids and led to the highest cell viability against oxidative stress. This implied that compounding process of DG and SDH produced more flavonoids, which exhibited high permeability in vitro as well as in situ blood–brain barrier model reporting in previous reports (Kaur et al, 2022).…”

Section: Resultssupporting

confidence: 71%

The synergistic effect of Angelica sinensis (Oliv.) Diels and Rehmannia glutinosa (Gaertn.) DC . on antioxidant activity and protective ability against cell injury

Zhang

Yang

et al. 2022

Journal of Food Biochemistry

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Oxidative stress‐induced dysfunction of nerve cells has been implicated as a crucial cause of cell death in neurodegenerative diseases. In Asian countries, herbs, such as Angelica sinensis (Oliv.) Diels (DG) and Rehmannia glutinosa (Gaertn.) DC. (SDH), have long be considered to have antiaging abilities. The herbs act as neuro protectants that rescue nerve cells from oxidative stress damage and apoptosis. Thus, developing herbal formulas can potentially lead to new treatments for neurodegenerative diseases. In this study, we compared the effective active components and antioxidant properties of extractive of DG and SDH (DG‐SDH) when formulated at different ratios. DG‐SDH formulated at a ratio of 3:2 (DG‐SDH [3:2]) produced the highest content of polysaccharides, polyphenols, and flavonoids. It also showed the best ability in removing DPPH and hydroxyl free radicals compared to single herb or other compounding ratio. The antioxidant activity of DG‐SDH (3:2) showed best synergistic effects in scavenging activity assays of DPPH free radicals and hydroxyl free radicals. DG‐SDH (3:2) could increase the cell viability of SHSY‐5Y cells, PC‐12 cells, and BV‐2 cells. In particular, DG‐SDH (3:2) protected SHSY‐5Y cells from H2O2‐induced cell injury by inhibiting excessive expression of reactive oxygen species (ROS), reducing the rate of apoptosis and restoring mitochondrial membrane potential. Actin‐Tracker Green and DAPI staining and fluorescence microscope observation confirmed that DG‐SDH (3:2) helped in preserving cell morphology under oxidative stress. These findings support that DG‐SDH (3:2) promote the neuroprotection against hydrogen peroxide and can serve as a novel therapy for neurodegenerative diseases. Practical applications This is the first study to investigate DG and SDH interaction between effective ingredients. These findings support that DG‐SDH (3:2) has the best synergistic effects in antioxidant activity and promote the neuroprotection against hydrogen peroxide. Hence, DG‐SDH (3:2) will be an excellent candidate to be developed as a functional food ingredients or nutraceuticals for neurodegenerative diseases.

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Section: Resultssupporting

confidence: 71%

The synergistic effect of Angelica sinensis (Oliv.) Diels and Rehmannia glutinosa (Gaertn.) DC . on antioxidant activity and protective ability against cell injury

Zhang

Yang

et al. 2022

Journal of Food Biochemistry

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“…Flavonoids are a group of plant metabolites which can improve the cognitive functions. They can work within the processes associated with AD ( Kaur et al, 2022 ; Maccioni et al, 2022 ). For example, quercetin belonging to the subcategory of flavonoids can significantly mitigate memory deficits in scopolamine mice model via protection against neuroinflammation and neurodegeneration ( Olayinka et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Eucommia ulmoides Olive Male Flower Extracts Ameliorate Alzheimer’s Disease-Like Pathology in Zebrafish via Regulating Autophagy, Acetylcholinesterase, and the Dopamine Transporter

Sun

Zhang

et al. 2022

Front. Mol. Neurosci.

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Alzheimer’s disease (AD) is the most prevalent neural disorder. However, the therapeutic agents for AD are limited. Eucommia ulmoides Olive (EUO) is widely used as a traditional Chinese herb to treat various neurodegenerative disorders. Therefore, we investigated whether the extracts of EUO male flower (EUMF) have therapeutic effects against AD. We focused on the flavonoids of EUMF and identified the composition using a targeted HPLC-MS analysis. As a result, 125 flavonoids and flavanols, 32 flavanones, 22 isoflavonoids, 11 chalcones and dihydrochalcones, and 17 anthocyanins were identified. Then, the anti-AD effects of the EUMF were tested by using zebrafish AD model. The behavioral changes were detected by automated video-tracking system. Aβ deposition was assayed by thioflavin S staining. Ache activity and cell apoptosis in zebrafish were tested by, Acetylcholine Assay Kit and TUNEL assay, respectively. The results showed that EUMF significantly rescued the dyskinesia of zebrafish and inhibited Aβ deposition, Ache activity, and occurrence of cell apoptosis in the head of zebrafish induced by AlCl3. We also investigated the mechanism underlying anti-AD effects of EUMF by RT-qPCR and found that EUMF ameliorated AD-like symptoms possibly through inhibiting excessive autophagy and the abnormal expressions of ache and slc6a3 genes. In summary, our findings suggested EUMF can be a therapeutic candidate for AD treatment.

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“…However this is an emerging area and much more research is required to better understand the health promoting properties of flavonoids and polyphenolic substances delivered by the gut-lung and gut-brain axes, this may represent a new therapeutic frontier [451][452][453][454][455][456]. A number of recent studies have shown the potential of dietary flavonoids to treat neurodegenerative conditions [457,458], depression, anxiety and cognitive dysfunction [459][460][461][462] and Alzheimer's disease [463][464][465][466][467][468].…”

Section: Flavonoids the Gut Microbiome And The Gut-brain And Gut-lung...mentioning

confidence: 99%

Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline

Melrose¹,

Smith²

2022

Front. Biosci. (Elite Ed)

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The aim of this review is to highlight the beneficial attributes of flavonoids, a diverse family of widely-distributed polyphenolic phytochemicals that have beneficial cell and tissue protective properties. Phytochemicals are widely distributed in plants, herbs and shrubs used in traditional complimentary medical formulations for centuries. The bioactive components that convey beneficial medicinal effects in these complex herbal preparations are now being identified using network pharmacology and molecular docking procedures that identify their molecular targets. Flavonoids have anti-oxidant, anti-inflammatory, antiviral, antibacterial and anti-cancer properties that have inspired the development of potent multifunctional derivatised flavonoids of improved efficacy. The antiviral properties of flavonoids and the emergence of the severe acute respiratory syndrome (SARS-CoV-2) pandemic has resulted in a resurgence of interest in phytochemicals in the search for efficacious compounds that can prevent viral infection or replication, with many promising plant compounds identified. Promising semi-synthetic flavonoid derivatives have also been developed that inhibit multiple pathological neurodegenerative processes; these offer considerable promise in the treatment of diseases of cognitive decline. Clinical trials are currently being undertaken to evaluate the efficacy of dietary supplements rich in flavonoids for the treatment of virally-mediated diseases. Such trials are expected to identify flavonoids with cell and tissue protective properties that can be harnessed in biomedical applications that may serve as supportive adjunctive procedures to conventional anti-viral drug therapies against diseases such as COVID-19.

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Potential of flavonoids as anti-Alzheimer’s agents: bench to bedside

Cited by 23 publications

References 143 publications

The synergistic effect of Angelica sinensis (Oliv.) Diels and Rehmannia glutinosa (Gaertn.) DC . on antioxidant activity and protective ability against cell injury

The synergistic effect of Angelica sinensis (Oliv.) Diels and Rehmannia glutinosa (Gaertn.) DC . on antioxidant activity and protective ability against cell injury

Eucommia ulmoides Olive Male Flower Extracts Ameliorate Alzheimer’s Disease-Like Pathology in Zebrafish via Regulating Autophagy, Acetylcholinesterase, and the Dopamine Transporter

Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline

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