Potential of electrospun core–shell structured gelatin–chitosan nanofibers for biomedical applications

Jalaja, K.; Naskar, Deboki; Kundu, Subhas C.; James, Nirmala Rachel

doi:10.1016/j.carbpol.2015.10.014

Cited by 108 publications

(64 citation statements)

References 53 publications

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“…These were utilized with gelatin‐chitosan core‐sheath fibers to enhance the mechanical integrity in wet environment without inducing cytotoxicity (as is the case with conventional cross‐linking agents). Human osteoblast‐like MG‐63 cells were grown much better on membranes crosslinked by naturally derived crosslinking agents than on membranes crosslinked by chemically synthesized glutaraldehyde agent …”

Section: Recent Results and Applicationsmentioning

confidence: 99%

Coaxial Electrospinning Formation of Complex Polymer Fibers and their Applications

2019

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The formation of fibers by electrospinning has experienced explosive growth in the past decade, recently reaching 4,000 publications and 1,500 patents per year. This impressive growth of interest is due to the ability to form fibers with a variety of materials, which lend themselves to a large and rapidly expanding set of applications. In particular, coaxial electrospinning, which forms fibers with multiple core−sheath layers from different materials in a single step, enables the combination of properties in a single fiber that are not found in nature in a single material. This article is a detailed review of coaxial electrospinning: basic mechanisms, early history and current status, and an in‐depth discussion of various applications (biomedical, environmental, sensors, energy, catalysis, textiles). We aim to provide readers who are currently involved in certain aspects of coaxial electrospinning research an appreciation of other applications and of current results.

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Section: Recent Results and Applicationsmentioning

confidence: 99%

Coaxial Electrospinning Formation of Complex Polymer Fibers and their Applications

2019

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“…Researchers have been working on the processing of chitosan to produce new biomaterials, especially developed for biomedical applications [1,2,3,4,5,6,7,8,9,10]. The advantage of this natural polymer is that it becomes water soluble in acidic conditions due to –NH 2 protonation as soon as its degree of acetylation is lower than 0.5.…”

Section: Introductionmentioning

confidence: 99%

“…The use of ionic liquid was also mentioned with 1,1,1,3,3,3-hexafluoro-2-propanol [28]. More generally, it has been shown that fine nanofibers can be obtained in chitosan blends with poly (vinyl alcohol) (PVA) [23,25,29,30], gelatin or collagen [2,7,31,32,33,34], silk fibroin [5], polycaprolactone [35] but mainly with poly(ethylene oxide) (PEO) [6,17,18,36,37,38,39,40,41]. Usually, to generate composite fibers the spinning solutions are obtained by mixing the two polymers solutions prepared separately in the same solvent.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Pure and Stable Chitosan Nanofibers by Electrospinning in the Presence of Poly(ethylene oxide)

Lemma

Bossard

Rinaudo³

2016

IJMS

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Electrospinning was employed to obtain chitosan nanofibers from blends of chitosans (CS) and poly(ethylene oxide) (PEO). Blends of chitosan (MW (weight-average molecular weight) = 102 kg/mol) and PEO (M (molecular weight) = 1000 kg/mol) were selected to optimize the electrospinning process parameters. The PEO powder was solubilized into chitosan solution at different weight ratios in 0.5 M acetic acid. The physicochemical changes of the nanofibers were determined by scanning electron microscopy (SEM), swelling capacity, and nuclear magnetic resonance (NMR) spectroscopy. For stabilization, the produced nanofibers were neutralized with K2CO3 in water or 70% ethanol/30% water as solvent. Subsequently, repeated washings with pure water were performed to extract PEO, potassium acetate and carbonate salts formed in the course of chitosan nanofiber purification. The increase of PEO content in the blend from 20 to 40 w% exhibited bead-free fibers with average diameters 85 ± 19 and 147 ± 28 nm, respectively. Their NMR analysis proved that PEO and the salts were nearly completely removed from the nanostructure of chitosan, demonstrating that the adopted strategy is successful for producing pure chitosan nanofibers. In addition, the nanofibers obtained after neutralization in ethanol-aqueous solution has better structural stability, at least for six months in aqueous solutions (phosphate buffer (PBS) or water).

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“…They used naturally derived cross‐linking agents, dextran aldehyde and sucrose aldehyde for increasing the biocompatibility and structural integrity of the core‐shell nanofibers. Their results show that cross‐linked core‐shell nanofibers are considerable for cell adhesion and proliferation in future (Jalaja, Naskar, Kundu, & James, ).…”

Section: Nanofibrous Fabrication Methodsmentioning

confidence: 99%

Bone tissue engineering: Adult stem cells in combination with electrospun nanofibrous scaffolds

Moradi

Golchin

Hajishafieeha

et al. 2018

Journal Cellular Physiology

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Since bone tissue lesions caused by several reasons and has global outbreak without any attentions to the modernity level of the countries. In the other hands treatment of patients with this problem faced to the several limitations, in this because the future of the bone lesions treatments is related to the future of the bone tissue engineering. This review tries to cover the most suitable stem cells and materials from either natural or synthetic sources for bone tissue engineering. These understanding points would help researchers to further uncover the application of different adult stem cell sources in electrospinning scaffolds, promotion of nanofibrous composite construct design and adult stem cell type selection to enhance cell function and bone tissue engineering, and link laboratory investigations to clinical applications.

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Potential of electrospun core–shell structured gelatin–chitosan nanofibers for biomedical applications

Cited by 108 publications

References 53 publications

Coaxial Electrospinning Formation of Complex Polymer Fibers and their Applications

Coaxial Electrospinning Formation of Complex Polymer Fibers and their Applications

Preparation of Pure and Stable Chitosan Nanofibers by Electrospinning in the Presence of Poly(ethylene oxide)

Bone tissue engineering: Adult stem cells in combination with electrospun nanofibrous scaffolds

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