Potential of Capric Acid in Neurological Disorders: An Overview

Shekhar, Nikhila; Tyagi, Sonia; Rani, Sweta; Thakur, Ajit Kumar

doi:10.1007/s11064-022-03809-4

Cited by 7 publications

(3 citation statements)

References 178 publications

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“…Capric acid has several targets including PPAR-γ, AMPA receptors, gut dysbiosis and inflammatory of oxidative stress pathways. Moreover, Capric acid exhibits an ameliorative effect of neurological diseases including affective disorders, epilepsy and Alzheimer's disease [53]. Resveratrol shows anti-aging, anticancer and antioxidant properties [54].…”

Section: Othersmentioning

confidence: 99%

The Controversial Roles of Areca Nut: Medicine or Toxin?

Liu

Chang

2023

IJMS

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Areca nut (AN) is used for traditional herbal medicine and social activities in several countries. It was used as early as about A.D. 25-220 as a remedy. Traditionally, AN was applied for several medicinal functions. However, it was also reported to have toxicological effects. In this review article, we updated recent trends of research in addition to acquire new knowledge about AN. First, the history of AN usage from ancient years was described. Then, the chemical components of AN and their biological functions was compared; arecoline is an especially important compound in AN. AN extract has different effects caused by different components. Thus, the dual effects of AN with pharmacological and toxicological effects were summarized. Finally, we described perspectives, trends and challenges of AN. It will provide the insight of removing or modifying the toxic compounds of AN extractions for enhancing their pharmacological activity to treat several diseases in future applications.

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Section: Othersmentioning

confidence: 99%

The Controversial Roles of Areca Nut: Medicine or Toxin?

Liu

Chang

2023

IJMS

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“…Capric acid, also known as decanoid acid, binds to the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, a glutamate receptor that mediates synaptic transmission in the brain. Capric acid has antioxidative effects in neuronal cells 38 and has been implicated in the amelioration of several neurological diseases 39 so that further studies of the potential role of decreased capric acid levels for the development of DSPN appear promising. Adrenic acid-derived epoxy fatty acids have anti-nociceptive properties and can reduce inflammatory pain 40 so that a link between lower levels and higher risk of DSPN appears biologically plausible.…”

Section: Discussionmentioning

confidence: 99%

The Interpretable Multimodal Machine Learning (IMML) framework reveals pathological signatures of distal sensorimotor polyneuropathy

Nguyen,

Garger,

et al. 2024

Preprint

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Distal sensorimotor polyneuropathy (DSPN) is a common neurological disorder in elderly adults and people with obesity, prediabetes and diabetes and is associated with high morbidity and premature mortality. DSPN is a multifactorial disease and not fully understood yet. In order to address this, we developed the Interpretable Multimodal Machine Learning (IMML) framework for predicting DSPN prevalence and incidence based on sparse multimodal data. Exploiting IMMLs interpretability further empowered biomarker identification. We leveraged the population-based KORA F4/FF4 cohort including 1,091 participants and their deep multimodal characterisation, i.e. clinical data, genomics, methylomics, transcriptomics, proteomics, inflammatory proteins and metabolomics. Clinical data alone was sufficient to stratify individuals with and without DSPN (AUROC = 0.752), whilst predicting DSPN incidence 6.5 years later strongly benefitted from clinical data complemented with two or more molecular modalities (improved AUROC >0.1, achieved AUROC of 0.714). Important and interpretable features of the prediction of incident DSPN included up-regulation of proinflammatory cytokines, down-regulation of SUMOylation pathway and essential fatty acids, thus yielding novel insights in the disease pathophysiology. These may become biomarkers for incident DSPN, guide prevention strategies and serve as proof of concept for the utility of IMML in studying complex diseases.

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“…Lauric acid also imparted apoptosis in endometrial and breast cancer cells [46]. Thakur and colleagues recently reviewed the potential effects of DA on neurological disorders [47]. DA was reported to curb the expression of inflammatory and metastasis markers in colon cancer cells [28].…”

Section: Discussionmentioning

confidence: 99%

Decanoic Acid Exerts Its Anti-Tumor Effects via Targeting c-Met Signaling Cascades in Hepatocellular Carcinoma Model

Yang,

Lee,

Deivasigamani

et al. 2023

Cancers

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DA, one of the medium-chain fatty acids found in coconut oil, is suggested to have diverse biochemical functions. However, its possible role as a chemoprevention agent in HCC has not been deciphered. Aberrant activation of c-Met can modulate tumor growth and progression in HCC. Here, we report that DA exhibited pro-found anti-tumor effects on human HCC through the suppression of HGF/c-Met signaling cascades in vitro and in vivo. It was noted that DA inhibited HGF-induced activation of c-Met and its downstream signals. DA induced apoptotic cell death and inhibited the expression of diverse tumorigenic proteins. In addition, DA attenuated tumor growth and lung metastasis in the HCC mouse model. Similar to in vitro studies, DA also suppressed the expression of c-Met and its downstream signals in mice tissues. These results highlight the substantial potential of DA in the prevention and treatment of HCC.

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Potential of Capric Acid in Neurological Disorders: An Overview

Cited by 7 publications

References 178 publications

The Controversial Roles of Areca Nut: Medicine or Toxin?

The Controversial Roles of Areca Nut: Medicine or Toxin?

The Interpretable Multimodal Machine Learning (IMML) framework reveals pathological signatures of distal sensorimotor polyneuropathy

Decanoic Acid Exerts Its Anti-Tumor Effects via Targeting c-Met Signaling Cascades in Hepatocellular Carcinoma Model

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