Potential of Black Phosphorus in Immune-Based Therapeutic Strategies

Dong, Wei; Wang, Hu; Liu, Hailin; Zhou, Chunqiao; Zhang, Xuelin; Wang, Song; He, Lin

doi:10.1155/2022/3790097

Cited by 6 publications

(3 citation statements)

References 139 publications

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“…The loaded BMP-2 released from the fibres promoted the proliferation and differentiation of preosteoblasts. The photothermal and photodynamic therapeutic effects of BP nanomaterials on bone regeneration have recently been investigated [86]. Wang et al [87] developed a BP/poly (lactic-co-glycolic acid) (PLGA) microsphere NIR light-triggered drug release system based on the photothermal effect of BP nanosheets.…”

Section: Black Phosphorusmentioning

confidence: 99%

Tissue-Engineered Nanomaterials Play Diverse Roles in Bone Injury Repair

et al. 2023

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Nanomaterials with bone-mimicking characteristics and easily internalized by the cell could create suitable microenvironments in which to regulate the therapeutic effects of bone regeneration. This review provides an overview of the current state-of-the-art research in developing and using nanomaterials for better bone injury repair. First, an overview of the hierarchical architecture from the macroscale to the nanoscale of natural bone is presented, as these bone tissue microstructures and compositions are the basis for constructing bone substitutes. Next, urgent clinical issues associated with bone injury that require resolution and the potential of nanomaterials to overcome them are discussed. Finally, nanomaterials are classified as inorganic or organic based on their chemical properties. Their basic characteristics and the results of related bone engineering studies are described. This review describes theoretical and technical bases for the development of innovative methods for repairing damaged bone and should inspire therapeutic strategies with potential for clinical applications.

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Section: Black Phosphorusmentioning

confidence: 99%

Tissue-Engineered Nanomaterials Play Diverse Roles in Bone Injury Repair

et al. 2023

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“…Therefore, BP nanoparticles offer greater potential for cancer therapy compared to other 2D nanomaterials. In addition, with its features of PTT, PDT, photoacoustic therapy (PAT), drug delivery system (DDS) and biological, BP nanoparticles would become a promising material for OS therapy ( Figure 1 ) ( Raucci et al, 2019a ; Zhang et al, 2019 ; Wang et al, 2020b ; Hu et al, 2022a ; Ma et al, 2022a ; Dong et al, 2022 ; Hou et al, 2022 ; Li et al, 2023b ; Li et al, 2023d ).…”

Section: Introductionmentioning

confidence: 99%

Black phosphorus, an advanced versatile nanoparticles of antitumor, antibacterial and bone regeneration for OS therapy

Sun,

Han,

Zhao

et al. 2024

Front. Pharmacol.

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Osteosarcoma (OS) is the most common primary malignant bone tumor. In the clinic, usual strategies for OS treatment include surgery, chemotherapy, and radiation. However, all of these therapies have complications that cannot be ignored. Therefore, the search for better OS treatments is urgent. Black phosphorus (BP), a rising star of 2D inorganic nanoparticles, has shown excellent results in OS therapy due to its outstanding photothermal, photodynamic, biodegradable and biocompatible properties. This review aims to present current advances in the use of BP nanoparticles in OS therapy, including the synthesis of BP nanoparticles, properties of BP nanoparticles, types of BP nanoparticles, and modification strategies for BP nanoparticles. In addition, we have discussed comprehensively the application of BP in OS therapy, including single, dual, and multimodal synergistic OS therapies, as well as studies about bone regeneration and antibacterial properties. Finally, we have summarized the conclusions, limitations and perspectives of BP nanoparticles for OS therapy.

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“…[10][11][12] Numerous studies have confirmed that BP, as a sonosensitizer, can induce ROS generation in cancer therapy, concomitantly inducing stronger immunogenicity. [13][14][15][16] Owing to the high proliferative capacity of cancer cells, the tumor microenvironment is characterized by abnormally high concentrations of glutathione (GSH) and hydrogen peroxide (H 2 O 2 ). [17][18][19] High GSH levels in cancer cells have been known to readily capture ROS in the cellular environment to generate oxidized glutathione disulfide (GSSG), resulting in a compromised effect of ROS therapy.…”

Section: Introductionmentioning

confidence: 99%

Glutathione Depletion-Induced ROS/NO Generation for Cascade Breast Cancer Therapy and Enhanced Anti-Tumor Immune Response

Wang,

Sang,

Chen

et al. 2024

IJN

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Introduction As an effective alternative choice to traditional mono-therapy, multifunctional nanoplatforms hold great promise for cancer therapy. Based on the strategies of Fenton-like reactions and reactive oxygen species (ROS)-mediated therapy, black phosphorus (BP) nanoplatform BP@Cu 2 O@L-Arg (BCL) co-assembly of cuprous oxide (Cu 2 O) and L-Arginine (L-Arg) nanoparticles was developed and evaluated for synergistic cascade breast cancer therapy. Methods Cu 2 O particles were generated in situ on the surface of the BP nanosheets, followed by L-Arg incorporation through electrostatic interactions. In vitro ROS/nitric oxide (NO) generation and glutathione (GSH) depletion were evaluated. In vitro and in vivo anti-cancer activity were also assessed. Finally, immune response of BCL under ultrasound was investigated. Results Cu 2 O was incorporated into BP to exhaust the overexpressed intracellular GSH in cancer cells via the Fenton reaction, thereby decreasing ROS consumption. Apart from being used as biocompatible carriers, BP nanoparticles served as sonosensitizers to produce excessive ROS under ultrasound irradiation. The enhanced ROS accumulation accelerated the oxidation of L-Arg, which further promoted NO generation for gas therapy. In vitro experiments revealed the outstanding therapeutic killing effects of BCL under ultrasound via mechanisms involving GSH deletion and excessive ROS and NO generation. In vivo studies have illustrated that the nanocomplex modified the immune response by promoting macrophage and CD8+ cell infiltration and inhibiting MDSC infiltration. Discussion BCL nanoparticles exhibited multifunctional characteristics for GSH depletion-induced ROS/NO generation, making a new multitherapy strategy for cascade breast cancer therapy.

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Potential of Black Phosphorus in Immune-Based Therapeutic Strategies

Cited by 6 publications

References 139 publications

Tissue-Engineered Nanomaterials Play Diverse Roles in Bone Injury Repair

Tissue-Engineered Nanomaterials Play Diverse Roles in Bone Injury Repair

Black phosphorus, an advanced versatile nanoparticles of antitumor, antibacterial and bone regeneration for OS therapy

Glutathione Depletion-Induced ROS/NO Generation for Cascade Breast Cancer Therapy and Enhanced Anti-Tumor Immune Response

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