Potential of antibody pair targeting conserved antigenic sites in diagnosis of SARS-CoV-2 variants infection

A pair of SARS-CoV-2 nucleocapsid protein monoclonal antibodies shows high specificity and sensitivity for diagnosis

“…SARS-CoV-2 is highly contagious and spreads very quickly, thus it is urgent to develop an accurate diagnosis. However, most of the effects nowadays are devoted to produce blocking antibody through screening B cells from the patients ( Cohen-Dvashi et al, 2022 ; Ju et al, 2020 ; Sun et al, 2022 ) while fewer reports on producing antibodies for diagnosis ( Wang et al, 2022 ). In this study, we aimed to produce monoclonal antibody (mAb) against the N protein of SARS-CoV-2, which we hope will be useful for COVID-19 diagnosis.…”