Potential metabolites of Arecaceae family for the natural anti-osteoarthritis medicine: A review

Sartinah, Ari; Nugrahani, Ilma; Ibrahim, Slamet; Anggadiredja, Kusnandar

doi:10.1016/j.heliyon.2022.e12039

Cited by 9 publications

(5 citation statements)

References 119 publications

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“…It also suppressed carrageenaninduced inflammation in rats by decreasing edema and prostaglandin E2 levels. Therefore, AN has a potential as an anti-osteoarthritis agent [88].…”

Section: Anti-osteoarthritismentioning

confidence: 99%

The Controversial Roles of Areca Nut: Medicine or Toxin?

Liu

Chang

2023

IJMS

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Areca nut (AN) is used for traditional herbal medicine and social activities in several countries. It was used as early as about A.D. 25-220 as a remedy. Traditionally, AN was applied for several medicinal functions. However, it was also reported to have toxicological effects. In this review article, we updated recent trends of research in addition to acquire new knowledge about AN. First, the history of AN usage from ancient years was described. Then, the chemical components of AN and their biological functions was compared; arecoline is an especially important compound in AN. AN extract has different effects caused by different components. Thus, the dual effects of AN with pharmacological and toxicological effects were summarized. Finally, we described perspectives, trends and challenges of AN. It will provide the insight of removing or modifying the toxic compounds of AN extractions for enhancing their pharmacological activity to treat several diseases in future applications.

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“…It also suppressed carrageenaninduced inflammation in rats by decreasing edema and prostaglandin E2 levels. Therefore, AN has a potential as an anti-osteoarthritis agent [88].…”

Section: Anti-osteoarthritismentioning

confidence: 99%

The Controversial Roles of Areca Nut: Medicine or Toxin?

Liu

Chang

2023

IJMS

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“…The interaction among these proinflammatory mediators results in synovial inflammation and cartilage or bone destruction, making TNF-α blockade an effective treatment for reducing RA symptoms. IL-1β and TNF-α are also recognized as therapeutic targets for RA treatment due to their role in chronic inflammatory pain associated with RA (Sartinah et al, 2022). Shows the summarized impact of CED doses tin Haemotological parameters on arthritic rats.…”

Section: Discussionmentioning

confidence: 99%

Mechanistic evaluation of antiarthritic and anti-inflammatory effect of campesterol ester derivatives in complete Freund’s adjuvant-induced arthritic rats

Nazir,

Ahmad,

Mobashar

et al. 2024

Front. Pharmacol.

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Background: Current therapies for RA have limitations and side effects, leading to a growing need for safer treatment options. Natural compounds from plants are gaining attention for their therapeutic benefits and fewer side effects. One such compound is the campesterol derivative, a steroid derivative occurring in plants. Studies have shown that this derivative has anti-inflammatory properties and can impact the expression of pro-inflammatory factors. The primary objective of this study was to explore and assess the potential therapeutic effects of Campesterol Ester Derivatives (CED) utilizing a rat model of arthritis induced by Complete Freund’s Adjuvant (CFA).Method: The rats were divided into specific experimental groups and treated with either CED or piroxicam (as a positive control) for a duration of 28 days. We determined the effects of CED on various parameters including paw edema, thermal hyperalgesia, and mechanical allodynia at different time points. Furthermore, serum levels of inflammatory cytokines, oxidative stress markers and histological analyses were performed. Additionally, mRNA expression levels of inflammatory markers, both pro-inflammatory (such as TNF-α, NF-κB, IL-6, COX-1, COX-2, and IL-4) and anti-inflammatory were analyzed.Results: In the arthritic rat model, CED exhibited significant anti-inflammatory effects and resulted in a notable reduction in paw edema levels compared to the control group. Histopathological examination of the treated rats’ paws confirmed a decrease in inflammation and tissue damage, including reduced pannus formation and bone erosion. Importantly, there were no observable signs of damage to the liver and kidneys following CED treatment, indicating its safety profile and potential for organ protection. At the molecular level, CED treatment downregulated mRNA expression levels of pro-inflammatory markers, indicating its ability to suppress inflammation. Conversely, certain anti-inflammatory markers were upregulated following CED treatment, suggesting a positive influence on the immune response. The positive effects of CED were not limited to joint inflammation; it also showed systemic benefits by positively influencing hematological and biochemical parameters.Conclusion: CED demonstrated promising therapeutic potential as an anti-inflammatory intervention for arthritis in the experimental rat model. Its ability to reduce inflammation, protect tissues, and improve organ function indicates its multifaceted benefits.

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“…Recently, the focus has shifted towards a more holistic approach, considering not only the functional properties of these alternative starches but also their role in supporting local economies [43] and promoting biodiversity. Studies are increasingly looking at the full life cycle of these starch sources, from cultivation to processing and end-use [44]. This contemporary research is crucial in shaping future food sustainability [45], particularly in the context of climate change and global food security challenges [44].…”

Section: Review Of Related Literaturementioning

confidence: 99%

“…Studies are increasingly looking at the full life cycle of these starch sources, from cultivation to processing and end-use [44]. This contemporary research is crucial in shaping future food sustainability [45], particularly in the context of climate change and global food security challenges [44]. The ongoing research into alternative starch sources like Nypa fruticans is a testament to this evolving and dynamic field [46].…”

Section: Review Of Related Literaturementioning

confidence: 99%

Transforming Milk Tea: Harnessing Nypa fruticans Mesocarp Flour as an Alternative for Tapioca Pearl for Sustainable Product Development and Innovation

Bacolod

2024

AIR

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Nypa fruticans, known as nypa, is a fast fruit-bearing mangrove palm with immeasurable potential. This dissertation used the mature fruit mesocarp, a byproduct of the Nypa palm. Thus, the byproduct is underrated for some reason, and mostly, they are neglected due to a lack of public knowledge of its most potential. This research used the Nypa Fruitican Mesocarp fruit from Brgy. Sabang, Surigao City. The quest for sustainable alternatives in exploring mesocarp flour as a potential substitute for traditional tapioca pearls in milk tea beverages. Begins with a comprehensive determination of mesocarp flour's functional properties using the ANNOVA ONE WAY test p>0.05. The result of all the data is 0.098; therefore, Pearl made from Mesocarp flour is a sustainable innovation. The functional properties of pearls made from cassava and mesocarps have no significant difference. Further, practical application forms a core component of this study, involving mesocarp flour formulations to replicate tapioca pearls. The cooking process and consumer acceptance are rigorously analyzed to determine their compatibility and desirability in this popular beverage. Analysis of variants showed that Pearls, once made from Mesocarp of Nypa fruticans incorporated into the milk tea beverage, have 4.3 overall acceptance, and the best organoleptic test with texture, aroma, and color is 4.3 (likes). Additionally, this research contributes a nuanced understanding of mesocarp flour's potential against traditional tapioca pearls, considering cost-effectiveness, scalability, and consumer preferences, thereby fostering innovation in sustainable beverage production.

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Potential metabolites of Arecaceae family for the natural anti-osteoarthritis medicine: A review

Cited by 9 publications

References 119 publications

The Controversial Roles of Areca Nut: Medicine or Toxin?

The Controversial Roles of Areca Nut: Medicine or Toxin?

Mechanistic evaluation of antiarthritic and anti-inflammatory effect of campesterol ester derivatives in complete Freund’s adjuvant-induced arthritic rats

Transforming Milk Tea: Harnessing Nypa fruticans Mesocarp Flour as an Alternative for Tapioca Pearl for Sustainable Product Development and Innovation

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