Potential Mediating Biomarkers underlying the Association of Body Mass Index or Waist Circumference with Blood Pressure: Results from Three Population-based Studies

Abstract

We conducted a comprehensive and in-depth assessment of body mass index (BMI) or waist circumference (WC) related to blood pressure (BP) and determined whether the association is mediated by the possible potential mediators in the cross-sectional survey of the Harbin Cohort Study on Diet, Nutrition and Chronic Non-communicable Diseases of 7094 participants aged 20–74 years, and validated the significant findings in the US National Health and Nutrition Examination Survey four cross-sectional cohorts (2005–2006, 2007–2008, 2009–2010, and 2011–2012) and the cohort data of the Harbin People’s Health Study (a median of 4.2 follow-up years). We observed that BMI or WC was positively associated with BP (all P-values < 0.0001). Mediation analyses consistently indicated that these associations were mediated mainly by insulin resistance (IR) as measured by the homeostasis model (HOMA-IR), followed by triglyceride (TG) and total cholesterol (TC), and fasting glucose (FG) in the three studies. The proportions via the mediation of insulin/HOMA-IR were 25~40%, TG and TC were 15~20%, and FG was 2~8%, respectively. These findings suggest that the mediators, insulin/insulin resistance, TG, TC, and FG, could be targeted for preventing hypertension among populations who were overweight or obesity.

A Preliminary Cohort Study Assessing Routine Blood Analyte Levels and Neurological Outcome after Spinal Cord Injury

“…6,7 Further, care must be taken to consider confounding variables such as diet, obesity, diabetes, and smoker status. [8][9][10] There is a growing appreciation of the value of analyzing routinely collected patient samples for relevant biomarkers in various fields, such as breast cancer, liver fibrosis, osteoporosis, and cardiovascular disease. [11][12][13][14] However, to our knowledge, there are no comprehensive studies examining the utility of multiple routinely measured biomarkers in SCI patients, despite the success of such techniques in the fields of Alzheimer's disease, cancer, and osteoarthritis.…”

Wnt5a regulates the cell proliferation and adipogenesis via MAPK‐independent pathway in early stage of obesity

“…The early stage of obesity was developed by feeding short‐term high fat diet in previous study (Lagathu et al, ; Zheng et al, ). Here high fat diet was fed and Lee index was used to measure the obesity at early stage in rats which was like Body Mass Index (BMI) evaluating the human health state in respect of obesity (Wu et al, ). The Lee index is a quantitative measure of obesity that correlates with body fat percentage in rodents which corresponds to the ratio between the cube root of body weight in grams and naso‐anal length in centimeters of the animals, then multiplied by 10 (Bernardis and Patterson, ; Li et al, ; Wang et al, ).…”

Joint interaction effect of metabolic syndrome and obstructive sleep apnea on hypertension

“…MS impairs endothelial function, reduces the ability of baroreceptors located on blood vessels to activate the sympathetic nervous system, decreases the distensibility of large elastic arteries, and disrupts the regulation of BP. In obese individuals, adipose tissue secretes adipocytokines, such as leptin, inducing insulin resistance and subsequently activating the sympathetic nervous system and renin‐angiotensin system . Some biological changes also occur in OSA in animal models .…”