Potential mechanism of action of J5 vaccine
in protection against severe bovine coliform mastitis

Dosogne, Hilde; Vangroenweghe, Frédéric; Burvenich, Christian

doi:10.1051/vetres:2001001

Cited by 49 publications

(51 citation statements)

References 51 publications

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“…This is related to the hypothesis of Dosogne et al (2002) that the J5 vaccination might induce a T helper 1 (Th 1 ) response. Indeed, the Th 1 response is characterized by the production of cytokines that enhance PMN diapedesis, as reflected in the high υ values.…”

Section: Stage 2: Estimation Of the Parametersmentioning

confidence: 82%

Mathematical Model of the Acute Inflammatory Response to Escherichia coli in Intramammary Challenge

Detilleux

Vangroenweghe

Burvenich

2006

Journal of Dairy Science

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We constructed a mathematical model of the early response to Escherichia coli infection of the mammary gland and explored the roles and interactions between inflammatory cells and bacteria. The model incorporates 3 equations that describe the interactions among bacteria, milk somatic cells, and blood leukocyte densities. These 3 equations were fitted to cell densities observed during acute inflammatory responses in unvaccinated and vaccinated heifers inoculated with 10 4

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Section: Stage 2: Estimation Of the Parametersmentioning

confidence: 82%

Mathematical Model of the Acute Inflammatory Response to Escherichia coli in Intramammary Challenge

Detilleux

Vangroenweghe

Burvenich

2006

Journal of Dairy Science

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“…E. coli serotypes in mastitic milk are similar to the faecal isolates. There are a very large number of E. coli serotypes as classified by surface antigens but the inner layer of the cell wall is common to all serotypes of E. coli and Enterobacteriaceae in general [65].…”

Section: E Coli As Pathogenmentioning

confidence: 99%

“…During multiplication, destruction and lysis, they release an outer-membrane component, the endotoxin or LPS [68], a thermostable molecule that is a unique structural component of the cell wall of the Gram-negative pathogens. Two phenotypic forms of coliforms with slightly different LPS can be distinguished: smooth with complete LPS sidechains and rough with incomplete LPS side-chains [65,154,169]. Many studies have shown that the pathogenicity of E. coli in the mammary gland is associated with LPS.…”

Section: Endotoxin As Local Mediatormentioning

confidence: 99%

“…Modulation of inflammation and tissue damage in coliform mastitis can be obtained through antibodies directed against the cell wall [65] or through LPS scavengers such as polymyxin B [262]. Nowadays, the tools, techniques and products to study and modulate host-pathogen interactions are made available by advances in molecular biology.…”

Section: Modulation Of Severitymentioning

confidence: 99%

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Severity of E. coli mastitis is mainly determined by cow factors

et al. 2003

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-Intramammary infections of dairy cows with Gram-positive bacteria such as Staphylococcus aureus (major cause of mastitis) have received a lot of attention because of their major economic impact on the dairy farm through production losses induced by an increase in somatic cell count. Management strategies, including greater awareness for efficient milking and hygienic measures, have limited the spread of Gram-positive bacteria and resulted in a significant decrease of proportion of S. aureus isolates and subclinical mastitis worldwide. Other organisms such as coliform subspecies and Streptococcus uberis, both environmental bacteria that cause clinical mastitis, have received less attention. Escherichia coli causes inflammation of the mammary gland in dairy cows around parturition and during early lactation with striking local and sometimes severe systemic clinical symptoms. This disease affects many high producing cows in dairy herds and may cause several cases of death per year in the most severe cases. It is well known that bacterial, cow and environmental factors are interdependent and influence mastitis susceptibility. Many studies, executed during the last decade, indicate that the severity of E. coli mastitis is mainly determined by cow factors rather than by E. coli pathogenicity. During E. coli mastitis, the host defense status is a cardinal factor determining the outcome of the disease. Today, we know that the neutrophil is a key factor in the cows' defense against intramammary infection with E. coli. Effective elimination of the pathogen by neutrophils is important for the resolution of infection and the outcome of E. coli mastitis. This review is a compilation of some major findings over the last 15 years concerning mainly host factors that modulate and influence neutrophil function and the mammary inflammatory reaction. The individual chapters address: virulence factors of E. coli strains, how neutrophils kill E. coli, connection between endotoxins, tumor necrosis factor-a and nitric oxide, severity classification of E. coli mastitis, lifespan of neutrophils, host factors that influence severity, tissue damage and production loss.

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“…Several attempts have been made to prevent cows from contracting E. coli mastitis through vaccination [40]. E. coli strain J5 is a rough (Rc) mutant strain that consists of a conserved lipid A portion of the cell wall and some common core polysaccharides.…”

Section: Introductionmentioning

confidence: 99%

The toll-like receptor-4 (TLR-4) pathway and its possible role in the pathogenesis ofEscherichia colimastitis in dairy cattle

et al. 2007

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-Mastitis is one of the most costly production diseases in the dairy industry that is caused by a wide array of microorganisms. In this review, we focus on the Gram-negative Escherichia coli infections that often occur at periods when the innate immune defence mechanisms are impaired (i.e., parturition through the first 60 days of lactation). There is substantial evidence demonstrating that at these periods, the expected influx of polymorphonuclear neutrophil leukocytes (PMN) into the mammary gland is delayed during inflammation after intramammary infection with E. coli. Here, we provide some hypotheses on the potential mechanisms of action on how the disease may develop under circumstances of immunosuppression, and describe the potential involvement of the toll-like receptor-4 signal transduction pathway in the pathogenesis of E. coli mastitis. In addition, some ideas are proposed to help prevent E. coli mastitis and potentially other diseases caused by Gram-negative infections in general.

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Potential mechanism of action of J5 vaccine in protection against severe bovine coliform mastitis

Cited by 49 publications

References 51 publications

Mathematical Model of the Acute Inflammatory Response to Escherichia coli in Intramammary Challenge

Mathematical Model of the Acute Inflammatory Response to Escherichia coli in Intramammary Challenge

Severity of E. coli mastitis is mainly determined by cow factors

The toll-like receptor-4 (TLR-4) pathway and its possible role in the pathogenesis ofEscherichia colimastitis in dairy cattle

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