Potential impact of parental Tdap immunization on infant pertussis hospitalizations

Abstract

We estimated the potential impact of parental Tdap immunization before delivery, at delivery and at the 2-week newborn visit on U.S. infant pertussis hospitalizations. We used published data for pertussis hospitalization rates among U.S. infants aged 0–4 months, the Tdap vaccine efficacy in adults, and the proportion of infants with pertussis <6 months of age in which either parent was the source (16%–40% from mothers and 16%–20% from fathers). Immunizing parents before pregnancy or ≥2 weeks prior to delivery should reduce pertussis hospitalizations among infants 0–4 months by 2694–9314 if both parents are vaccinated, and by 1347–6909 if only mothers are vaccinated. Greater reductions in pertussis hospitalizations would be achieved if parents are immunized ≥2 weeks prior to delivery than after delivery or the 2-week newborn visit. Although immunizing parents prior to pregnancy or delivery is best, immunizing parents in the postpartum period should provide protection to that newborn and to infants of subsequent pregnancies.

Receipt of pertussis vaccine during pregnancy across 7 Vaccine Safety Datalink Sites

“…Administering Tdap during the third trimester of pregnancy is likely to be the most effective strategy for preventing severe pertussis infections in newborns (Anon., 2013;Peters et al, 2012;Terranella et al, 2013) and thus the CDPH and ACIP recommendation has been broadly endorsed (A.C.O.G. Committee Opinion No.…”

Management and prevention of pertussis infection in neonates

“…Also, the maximum response was not achieved until 14 days after Tdap administration [68,69]. As a matter of fact, a greater reduction in pertussis hospitalization in infants 0-4 months old would be achieved if parents were immunized at least 2 weeks prior to delivery rather than after delivery or at the 2-week newborn visit [70].…”

Does googling for preconception care result in information consistent with international guidelines: a comparison of information found by Italian women of childbearing age and health professionals

“…This finding reflects the fact that pertussis is not sufficiently recognized as a threat for newborns. In several outbreaks the maternal-newborn transmission has been observed as one of the main transmission patterns [39]. …”