Potential Genotoxicity in Copper Sulphate Treated Mice.

Fahmy, Maha A.

doi:10.1508/cytologia.65.235

Cited by 14 publications

(2 citation statements)

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“…Similar results have also been reported in Swiss albino mice after oral, subcutaneous and intraperitoneal exposures to copper sulphate. Fahmy (2000) reported teratogenic effects of copper in carp at much lower copper concentrations (0.051 mg/L at pH 7.6 and 0.019 mg/L at pH 6.3) where deformed head, spinal column, upper jaw and a small or absent swim bladder was reported. Copper toxicity is believed to be due to nonspecific binding of the reactive metal cation (Cu 2+ ) to biologically important molecules (Rakshit and Gangopadhyay, 2015).…”

Section: Discussionmentioning

confidence: 98%

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Solvent-less Synthesis, Antimalarial and Toxicity Evaluation of Lumefantrine-Copper Complex in Swiss Mice

Arise¹,

Tella²,

Iyiola³

et al. 2016

Not Sci Biol

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The antimalarial efficacy and safety of mechanically induced solventlessly synthesized lumefantrine-copper complex were investigated in experimental mice. Parasite level in Plasmodium berghei-infected mice treated with lumefantrine -copper complex (LCC) significantly declined (p < 0.05) at day 3 and was comparable with that of chloroquine-treated mice. LCC attained a percentage chemo-suppression which was significantly higher than those of pure lumefantrine and comparable with chloroquine. Pure lumefantrine attained a clearance of 88.52%, chloroquine was 91.95%, while LCC was 95.10%. Administration of lumefantrine, LCC and chloroquine to mice for 7 days caused a significant increase (p < 0.05) in the activities of alkaline phosphatase, acid phosphatase and lactate dehydrogenase in the liver when compared with the control, and a significant reduction (p < 0.05) in the liver and kidney activities of alanine and aspartate aminotransferases when compared with the control. Also, there was a significant decrease (p < 0.05) in the levels of PCV, Hb, RBC and lymphocytes and a significant increase (p < 0.05) in the white blood cells count and neutrophil counts in all the treatment groups when compared with control. Alterations in the biochemical parameters and chromosomal aberration in the organs investigated suggested selective, chromosomal and functional toxicity of the tested drugs.Keywords: chloroquine, chromosomal aberration, lumefantrine-copper complex, malaria, solvent-less synthesis Abbreviations: ALT -alanine aminotransferase, AST -aspartate aminotransferase, b.wt. -body weight, LCC -lumefantrinecopper complex, PCV -packed cell volume, Hb -haemoglobin level, WBC -white blood cells count, RBC -red blood cell count, MCV -mean corpuscular volume, MCH -mean corpuscular, TNMA -total number of metaphases analysed, MCAmetaphases with chromosomal aberration, MI -mitotic index, CA -chromosomal aberration Available online: www.notulaebiologicae.ro

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Section: Discussionmentioning

confidence: 98%

“…Malaria, a life-threatening disease, occurs as a result of bites of infected female mosquitoes. About 214 million cases were reported in 2015, while there was about 37% global decrease in malaria incidence between 2000(WHO, 2015. It is caused by the parasitic unicellular protozoans that belong to the genus Plasmodium.…”

Section: Introductionmentioning

confidence: 99%