Potential for oxytocin use in children and adolescents with mental illness

Netherton, Elisabeth; Schatte, Dawnelle

doi:10.1002/hup.1212

Cited by 19 publications

(17 citation statements)

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“…Considering the known propensity for hypothalamic involvement in children with CP, and the high incidence of permanent diabetes insipid us (loss of functional desmopressin production and secretion) correlating with hypothalamic, infundibular, and neurohypophyseal dysfunction, we postulate that oxytocin deficiency may also be a common development in these patients, and may partially contribute to the observed social dysfunction. Although no data is currently available to support this theory, recent experiments performed following inhaled administration of oxytocin have demonstrated improved potential for trust and social connectivity in children with autism spectrum disorder, conduct disorders, attachment disorders, anxiety, and depression[34,35]. The prosocial effects of oxytocin are known to play an important role in developing attachment and trust, social memory, and fear reduction[36–38].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Neurobehavioral, Social, and Emotional Dysfunction in Patients Treated for Childhood Craniopharyngioma: A Systematic Literature Review

et al. 2013

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BackgroundCraniopharyngiomas (CP) are locally invasive and frequently recurring neoplasms often resulting in neurological and endocrinological dysfunction in children. In addition, social-behavioral impairment is commonly reported following treatment for childhood CP, yet remains to be fully understood. The authors aimed to further characterize the prevalence of neurobehavioral, social, and emotional dysfunction in survivors of childhood craniopharyngiomas.Materials and MethodsA systematic literature review was conducted in PubMed to identify studies formally assessing neurobehavioral, social, and emotional outcomes in patients treated for CP prior to 18 years of age. Studies published between the years 1990-2012 that reported the primary outcome (prevalence of neurobehavioral, social, emotional/affective dysfunction, and/or impaired quality of life (QoL)) in ≥10 patients were included.ResultsOf the 471 studies screened, 11 met inclusion criteria. Overall neurobehavioral dysfunction was reported in 51 of 90 patients (57%) with available data. Social impairment (i.e. withdrawal, internalizing behavior) was reported in 91 of 222 cases (41%). School dysfunction was reported in 48 of 136 patients (35%). Emotional/affective dysfunction was reported in 58 of 146 patients (40%), primarily consisting of depressive symptoms. Health related quality of life was affected in 49 of 95 patients (52%). Common descriptors of behavior in affected children included irritability, impulsivity, aggressiveness, and emotional outbursts.ConclusionsNeurobehavioral, social, and emotional impairment is highly prevalent in survivors of childhood craniopharyngioma, and often affects quality of life. Thorough neurobehavioral/emotional screening and appropriate counseling is recommended in this population. Additional research is warranted to identify risk factors and treatment strategies for these disorders.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Neurobehavioral, Social, and Emotional Dysfunction in Patients Treated for Childhood Craniopharyngioma: A Systematic Literature Review

et al. 2013

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“…Die Wirksamkeit von intranasal appliziertem Oxytocin ist belegt [17] [33,55]. In den meisten Studien wurden zwischen 8 und 40 IU Oxytocin intranasal verabreicht; dabei wurde über keine Nebenwirkungen berichtet [33,55,56]. Trotz der belegten, durch Oxytocin hervorgerufenen Effekte bleibt der Mechanismus von intranasaler Gabe bis zur Wirkungsentfaltung ungeklärt und muss weiter untersucht werden [55].…”

Section: Oxytocin In Klinischen Studienunclassified

Oxytocin und die suchterhaltenden Mechanismen der Alkoholabhängigkeit

2017

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Oxytocin and the mechanisms of alcohol dependenceSummary One of the crucial purposes of treating alcohol-dependent patients is to enhance their ability to stay abstinent after detoxification therapy. Anxiety and stress vulnerability are the main factors provoking alcohol craving and relapse. In the first months of abstinence, alcohol-dependent patients frequently show sleep disturbances, irritability and depression, indicating chronic activation of stress pathways. In addition, the loss of confidence in interpersonal interactions results in social withdrawal and reduced willingness to participate in therapeutic programs. Current research shows that the peptide hormone oxytocin exerts substantial anxiolytic effects and facilitates prosocial behavior. Oxytocin can be safely ap-K

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“…Importantly, oxytocin does not condition the attachment process but plays the role of modeling the attachment [22]. It is involved in the pathophysiology of mental disorders such as affective disorders, schizophrenia, and autism [23]. It is a key mediator of complex emotional and social behavior, both in humans and in animals [24].…”

Section: Methodmentioning

confidence: 99%

“…Oxytocin is also involved in sexual behavior and stress responses [19]. It reduces anxiety, aggression and stress [23]. This happens with the participation of the amygdala and its connections to the brainstem and hypothalamus.…”

Section: Methodmentioning

confidence: 99%

“…What's more, oxytocin reduces anxiety levels, blood pressure, cortisol levels and accelerates wound healing [28]. It was observed that people who experienced childhood violence or other traumatic situations have lower levels of oxytocin [23]. These observations gave rise to attempts to use intranasally administered oxytocin to compensate its level in people who have experienced violence.…”

Section: Methodmentioning

confidence: 99%

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The role of oxytocin in the pathogenesis and treatment of schizophrenia

Jusiak

Brudkowska

et al. 2017

Current Problems of Psychiatry

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Introduction: Until recently, oxytocin was mainly associated with the pathophysiology of childbirth and sexual functions, but lately this hormone has become the object of interest to psychiatry and psychology due to the significant influence of oxytocin on human behavior in the field of social and emotional functioning. Current scientific research focuses on the participation of oxytocin in the pathogenesis and therapy of mental disorders.Aim: The aim of the paper is to present, on the basis of available literature, the significance of oxytocin for various psychological functions, with particular emphasis on the influence of oxytocin on the course and clinical picture of schizophrenia.Method: Available articles from the Medline / PubMed database were analyzed, which were searched using keywords: oxytocin, schizophrenia, therapeutic use of oxytocin, social cognition, positive symptoms, negative symptoms and time descriptors: 2013-2017. There are included articles published in Polish and English.Results:The research results carried out so far suggest that oxytocin plays a significant role in modulating complex socio-emotional behaviors in schizophrenic patients. The existing research results also indicate a relationship between the dysregulation of the oxytocinergic system and the pathophysiology of schizophrenia. Many of the studies prove that there is a relationship between the level of oxytocin in the patients' blood plasma and the severity of the disease symptoms. Recent genetic studies indicate a possible relationship between polymorphism of oxytocin genesand polymorphism of oxytocin receptor genes and the risk of developing schizophrenia.Conclusions: Contemporary research on the therapeutic potential of oxytocin and its influence on the functioning of schizophrenia patients seem to be very promising and may contribute to increasing the effectiveness of treatment of schizophrenia and possibly other mental disorders, which in turn will improve the quality of life of patients in cognitive, social and emotional functioning.

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Potential for oxytocin use in children and adolescents with mental illness

Abstract: Given the research already conducted, we recommend investigation into the therapeutic use of oxytocin in adolescent populations for anxiety, psychosis, attachment disorders, and conduct disorder.

Cited by 19 publications

References 129 publications

Prevalence of Neurobehavioral, Social, and Emotional Dysfunction in Patients Treated for Childhood Craniopharyngioma: A Systematic Literature Review

Prevalence of Neurobehavioral, Social, and Emotional Dysfunction in Patients Treated for Childhood Craniopharyngioma: A Systematic Literature Review

Oxytocin und die suchterhaltenden Mechanismen der Alkoholabhängigkeit

The role of oxytocin in the pathogenesis and treatment of schizophrenia

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