Potential effects of zinc on information processing in boys with attention deficit hyperactivity disorder

Yorbık, Özgür; Ozdag, Mehmet Fatih; Olgun, Abdullah; Şenol, Mehmet Güney; Bek, Semai; Akman, Şerif

doi:10.1016/j.pnpbp.2007.11.009

Cited by 51 publications

(47 citation statements)

References 42 publications

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“…Using an auditory oddball task, Yorbik et al (2008) examined the effect of plasma zinc level on information processing in children with and without AD/HD, with reduced amplitude and longer latency P3 interpreted in terms of deficient working memory updating. A zinc-deficient AD/HD group showed an earlier N2 component than controls, suggesting an unique effect on inhibition processing.…”

Section: Attentionmentioning

confidence: 99%

Ten years on: A follow-up review of ERP research in attention-deficit/hyperactivity disorder

Johnstone

Barry

Clarke

2013

Clinical Neurophysiology

145

132

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This article reviews the event-related potential (ERP) literature in relation to attention-deficit/hyperactivity disorder (AD/HD) over the years [2002][2003][2004][2005][2006][2007][2008][2009][2010][2011][2012]. ERP studies exploring various aspects of brain functioning in children and adolescents with AD/HD are reviewed, with a focus on group effects and interpretations in the domains of attention, inhibitory control, performance monitoring, non-pharmacological treatments, and ERP/energetics interactions. There has been a distinct shift in research intensity over the past 10 years, with a large increase in ERP studies conducted in the areas of inhibitory control and performance monitoring. Overall, the research has identified a substantial number of ERP correlates of AD/HD. Robust differences from healthy controls have been reported in early orienting, inhibitory control, and error-processing components. These data offer potential to improve our understanding of the specific brain dysfunction(s) which contribute to the disorder. The literature would benefit from a more rigorous approach to clinical group composition and consideration of age effects, as well as increased emphasis on replication and extension studies using exacting participant, task, and analysis parameters. • Research focus and intensity has been in the domains of attention, inhibitory control, performance monitoring, non-pharmacological treatments, and ERP/energetics interactions.• Some consistent differences from healthy controls are emerging, but more emphasis on replication and extension studies is needed to increase the consistency and specificity of results. AbstractThis article reviews the event-related potential (ERP) literature in relation to attentiondeficit/hyperactivity disorder (AD/HD) over the years 2002 to 2012. ERP studies exploring various aspects of brain functioning in children and adolescents with AD/HD are examined, with a focus on group effects and interpretations in the domains of attention, inhibitory control, performance monitoring, non-pharmacological treatments, and ERP/energetics interactions. There has been a distinct shift in research intensity over the past 10 years, with a large increase in ERP studies conducted in the areas of inhibitory control and performance monitoring. Overall, the research has identified a substantial number of ERP correlates of AD/HD. Robust differences from healthy controls have been reported in early orienting, inhibitory control, and error-processing components.These data offer potential to improve our understanding of the specific brain dysfunction(s) which contribute to the disorder. The literature would benefit from a more rigorous approach to clinical group composition and consideration of age effects, as well as increased emphasis on replication and extension studies using exacting participant, task, and analysis parameters.

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Section: Attentionmentioning

confidence: 99%

Ten years on: A follow-up review of ERP research in attention-deficit/hyperactivity disorder

Johnstone

Barry

Clarke

2013

Clinical Neurophysiology

145

132

View full text Add to dashboard Cite

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“…ADHD is one of the most common psychiatric problems in childhood and adolescence (1,2). An estimated 5% to 12% of school-age children suffer from ADHD (3). The disease can negatively affect the social interactions of children and adolescents.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Methylphenidate Supplemented by Zinc, Calcium, and Magnesium for Treatment of ADHD Patients in the City of Zahedan

2016

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“…Furthermore, zinc treatment was reported significantly superior to placebo in reducing symptoms of hyperactivity, impulsivity and impaired socialization in ADHD patients [58,59]. Another preliminary human study showed that many children with ADHD have lower zinc concentration in comparison to healthy children and zinc supplement as an adjunct to methylphenidate has favourable effects in the treatment of ADHD children, pointing to the possible association of zinc deficiency and ADHD pathophysiology [60].…”

Section: Discussionmentioning

confidence: 99%

Fetal and Neonatal Endocrine Disruptors

2015

Environmental Hazards and Neurodevelopment

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Abstract:The interactions between genes and the environment are now regarded as the most probable explanation for autism. In this review, we summarize the results of a metallomics study in which scalp hair concentrations of 26 trace elements were examined for 1,967 autistic children (1,553 males and 414 females aged 0-15 years-old), and discuss recent advances in our understanding of epigenetic roles of infantile mineral imbalances in the pathogenesis of autism. In the 1,967 subjects, 584 (29.7%) and 347 (17.6%) were found deficient in zinc and magnesium, respectively, and the incidence rate of zinc deficiency was estimated at 43.5% in male and 52.5% in female infantile subjects aged 0-3 years-old. In contrast, 339 (17.2%), 168 (8.5%) and 94 (4.8%) individuals were found to suffer from high burdens of aluminum, cadmium and lead, respectively, and 2.8% or less from mercury and arsenic. High toxic metal burdens were more frequently observed in the infants aged 0-3 years-old, whose incidence rates were 20.6%, 12.1%, 7.5%, 3.2% and 2.3% for aluminum, cadmium, lead, arsenic and mercury, respectively. These findings suggest that infantile zinc-and magnesium-deficiency and/or toxic metal burdens may be critical and induce epigenetic alterations in the genes and genetic regulation mechanisms of neurodevelopment in the autistic children, and demonstrate that a time factor "infantile window" is also critical for neurodevelopment and probably for therapy. Thus, early metallomics analysis may lead to early screening/estimation and treatment/prevention for the autistic neurodevelopment disorders.

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Potential effects of zinc on information processing in boys with attention deficit hyperactivity disorder

Cited by 51 publications

References 42 publications

Ten years on: A follow-up review of ERP research in attention-deficit/hyperactivity disorder

Ten years on: A follow-up review of ERP research in attention-deficit/hyperactivity disorder

Effectiveness of Methylphenidate Supplemented by Zinc, Calcium, and Magnesium for Treatment of ADHD Patients in the City of Zahedan

Fetal and Neonatal Endocrine Disruptors

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