Potential effects and molecular mechanisms of melatonin on the dopaminergic neuronal differentiation of human amniotic fluid mesenchymal stem cells

Phonchai, Ruchee; Phermthai, Tassanee; Kitiyanant, Narisorn; Suwanjang, Wilasinee; Kotchabhakdi, Naiphinich; Chetsawang, Banthit

doi:10.1016/j.neuint.2018.12.012

Cited by 18 publications

(20 citation statements)

References 64 publications

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“…Fang et al (119) showed that AD-MSCs pretreated with melatonin showed enhanced beneficial effects in canine acute liver injury. In vitro experiments showed that melatonin pretreatment improved the survival of AD-MSCs by activating Nrf2 through the MT1/MT2 receptor pathway, stimulating ERAD, inhibiting NF-κB and ERS, and alleviating AD-MSC senescence (120). Another study indicated that melatonin pretreatment enhanced the homing capacity of BM-MSCs in a rat model of liver fibrosis (121).…”

Section: Improved Msc Treatment Efficacy (Factors Influencing the Efficacy Of Msc)mentioning

confidence: 99%

The Application of Mesenchymal Stem Cells in the Treatment of Liver Diseases: Mechanism, Efficacy, and Safety Issues

et al. 2021

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Mesenchymal stem cell (MSC) transplantation is a novel treatment for liver diseases due to the roles of MSCs in regeneration, fibrosis inhibition and immune regulation. However, the mechanisms are still not completely understood. Despite the significant efficacy of MSC therapy in animal models and preliminary clinical trials, issues remain. The efficacy and safety of MSC-based therapy in the treatment of liver diseases remains a challenging issue that requires more investigation. This article reviews recent studies on the mechanisms of MSCs in liver diseases and the associated challenges and suggests potential future applications.

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Section: Improved Msc Treatment Efficacy (Factors Influencing the Efficacy Of Msc)mentioning

confidence: 99%

The Application of Mesenchymal Stem Cells in the Treatment of Liver Diseases: Mechanism, Efficacy, and Safety Issues

et al. 2021

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“…It was shown that melatonin promoted 1% fetal bovine serum (FBS)-induced neuronal differentiation during the proliferation period of E15.5 ganglionic eminence NSCs but it decreased neuronal differentiation of the NSCs during the differentiation period [ 28 ]. Melatonin also promoted the neuronal differentiation of amniotic fluid mesenchymal stem cells and mouse-induced pluripotent stem cells, in which ERK/CaMKII and PI3K/Akt signaling pathways were, respectively, involved [ 29 , 30 ]. In adult rat hippocampal organotypic culture experiments, melatonin was found to promote dendritogenesis by the activation of CaMKII, protein kinase C (PKC), and ERK1/2 with partial involvement of the melatonin receptors [ 31 , 32 ].…”

Section: Roles Of Melatonin In Modulation Of Neurogenesismentioning

confidence: 99%

Protective Effects of Melatonin on Neurogenesis Impairment in Neurological Disorders and Its Relevant Molecular Mechanisms

Leung

Cheung

Ngai

et al. 2020

IJMS

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Neurogenesis is the process by which functional new neurons are generated from the neural stem cells (NSCs) or neural progenitor cells (NPCs). Increasing lines of evidence show that neurogenesis impairment is involved in different neurological illnesses, including mood disorders, neurogenerative diseases, and central nervous system (CNS) injuries. Since reversing neurogenesis impairment was found to improve neurological outcomes in the pathological conditions, it is speculated that modulating neurogenesis is a potential therapeutic strategy for neurological diseases. Among different modulators of neurogenesis, melatonin is a particularly interesting one. In traditional understanding, melatonin controls the circadian rhythm and sleep–wake cycle, although it is not directly involved in the proliferation and survival of neurons. In the last decade, it was reported that melatonin plays an important role in the regulation of neurogenesis, and thus it may be a potential treatment for neurogenesis-related disorders. The present review aims to summarize and discuss the recent findings regarding the protective effects of melatonin on the neurogenesis impairment in different neurological conditions. We also address the molecular mechanisms involved in the actions of melatonin in neurogenesis modulation.

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“…Stem cells express MT1 and MT2 and therefore, investigating the involvement of melatonin in stem cell mechanisms is crucial. In a recent study, melatonin spurred differentiation of amniotic fluid (AF)- MSCs into dopaminergic neurons, potentially through the initiation of ERK and CaMKII signaling, regulated by melatonin receptors [ 72 ]. Moreover, targeting melatonin receptors in stem cells may further bolster their differentiative and neuroprotective effects.…”

Section: Novel Evidence Supporting Melatonin As An Effective Theramentioning

confidence: 99%

“…Antioxidants 2020, 9, x FOR PEER REVIEW 6 of 15 regulated by melatonin receptors [72]. Moreover, targeting melatonin receptors in stem cells may further bolster their differentiative and neuroprotective effects.…”

Section: Novel Evidence Supporting Melatonin As An Effective Therapeutic Agent In Strokementioning

confidence: 99%

Melatonin—A Potent Therapeutic for Stroke and Stroke-Related Dementia

et al. 2020

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Secreted by the pineal gland to regulate the circadian rhythm, melatonin is a powerful antioxidant that has been used to combat oxidative stress in the central nervous system. Melatonin-based therapies have been shown to provide neuroprotective effects in the setting of ischemic stroke by mitigating neuroinflammation and accelerating brain tissue restoration. Melatonin treatment includes injection of exogenous melatonin, pineal gland grafting and melatonin-mediated stem cell therapy. This review will discuss the current preclinical and clinical studies investigating melatonin-based therapeutics to treat stroke.

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Potential effects and molecular mechanisms of melatonin on the dopaminergic neuronal differentiation of human amniotic fluid mesenchymal stem cells

Cited by 18 publications

References 64 publications

The Application of Mesenchymal Stem Cells in the Treatment of Liver Diseases: Mechanism, Efficacy, and Safety Issues

The Application of Mesenchymal Stem Cells in the Treatment of Liver Diseases: Mechanism, Efficacy, and Safety Issues

Protective Effects of Melatonin on Neurogenesis Impairment in Neurological Disorders and Its Relevant Molecular Mechanisms

Melatonin—A Potent Therapeutic for Stroke and Stroke-Related Dementia

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