Potential effectiveness of stored cord blood (non-frozen) for emergency use

The Feasibility of Using Blood Bank-Stored (4°C) Cord Blood, Unmatched for HLA for Marrow Transplantation

“…4,5 In this xenogeneic mouse model, the human CB cells seem to serve as a transient bridge, giving the animal's own stem cells an opportunity (as well as stimulation) to repopulate the hematopoietic compartments.…”

“…To minimize the possibility of clinical complications of transplant rejection (failure to implant) or graft vs host disease (GVHD), the selection of CB donors that are closely matched with the recipient for HLA antigens is the most desirable choice. However, in earlier publications, Ende et al, 3 Lu and Ende, 4 and Ende et al 5 have suggested that even if HLA compatibility is disregarded, umbilical CB still might be used effectively in lieu of bone marrow for transplantation, and this is supported by the clinical results of patients with 1, 2, or 3 antigen mismatches who have successfully received allogeneic CB transplants. 2 Previous results 4,5 have indicated that CB stored for 5 to 21 days under blood bank conditions at 4°C will rescue mice from the effects of lethal irradiation by acting as a temporary bridge and by stimulating endogenous hematopoiesis leading to self-reconstitution.…”

“…However, in earlier publications, Ende et al, 3 Lu and Ende, 4 and Ende et al 5 have suggested that even if HLA compatibility is disregarded, umbilical CB still might be used effectively in lieu of bone marrow for transplantation, and this is supported by the clinical results of patients with 1, 2, or 3 antigen mismatches who have successfully received allogeneic CB transplants. 2 Previous results 4,5 have indicated that CB stored for 5 to 21 days under blood bank conditions at 4°C will rescue mice from the effects of lethal irradiation by acting as a temporary bridge and by stimulating endogenous hematopoiesis leading to self-reconstitution. 6 Furthermore, in methylcellulose cultures, blast colonies were generated from 21-day-old stored CB, and replating these colonies produced secondary colonies 62.5% of the time.…”

Role of transfusion medicine in post-crisis nuclear leakage

“…[4] The irreversibly destroyed hematopoietic tissue (category V) becomes a problem that requires hematopoietic stem cell transplantation therapy. [56] However, this technique is new and was not available at the time of Chernobyl accident. Hence, a future follow-up on usage of this new transplantation practice in the emerging cases in the present Japanese crisis is recommended.…”