Potential effect of compounds isolated from Coffea arabica against UV-B induced skin damage by protecting fibroblast cells

Cho, Yong‐Hun; Bahuguna, Ashutosh; Kim, Han-Hyuk; Kim, Dongin; Kim, Hyeon-Jeong; Yu, Jae-Myo; Jung, Hak Hyun; Jang, Jihoon; Kwak, Jae-Hoon; Park, Geun-Hye; Kwon, O-Jun; Cho, Young Je; An, Jeong Yeon; Jo, Cheorun; Kang, Sun Chul; An, Bong-Jeun

doi:10.1016/j.jphotobiol.2017.08.015

Cited by 35 publications

(28 citation statements)

References 40 publications

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“…Additionally, chlorogenic acid presents a good sun protection factor (SPF)-a factor that measures the capacity of a compound to absorb UV radiation-and in vitro DNA protective effect. This study indicates that this phenolic compound has potential to be used as a preventive agent against premature skin aging induced by UV radiation [45]. Although this study was performed in coffee beans, chlorogenic acid is also the major phenolic in CS (1-6%).…”

Section: Protection Against Skin Uv Damagementioning

confidence: 94%

“…While there are more than 25 types of MMPs, UV light exposure is particularly associated with induction of MMP-1, MMP-3, and MMP-9, which play critical roles in the skin aging process [44]. Recently, the potential effect of compounds isolated from Coffea arabica beans against UV-B induced skin damage was evaluated by Cho et al [45]. The results evidenced individual anti-wrinkle effects of chlorogenic acid, pyrocatechol, and 3,4,5-tricaffeoyl quinic acid against UV-B stimulated mouse fibroblast cells (CCRF), by measuring expression levels of MMP-1, MMP-3, MMP-9, and type-I procollagen.…”

Section: Protection Against Skin Uv Damagementioning

confidence: 99%

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Coffee Silverskin: A Review on Potential Cosmetic Applications

2018

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Coffee silverskin, the major coffee-roasting by-product, is currently used as fuel and for soil fertilization. However, there are several studies reporting silverskin as a good source of bioactive compounds that can be extracted and further used by cosmetic industry. Its high antioxidant potential may be due to the synergistic interaction of chlorogenic acids (1-6%), caffeine (0.8-1.25%), and melanoidins (17-23%), among other antioxidant compounds. The bioactive compounds of silverskin can answer to the new fields of cosmetic industry on natural active ingredient resources that improve health skin appearance, counteract skin aging and related diseases, in an environmentally friendly approach. Skin aging is a complex process associated with oxidative metabolism and reactive oxygen species (ROS) generation. ROS production increase matrix metalloproteinases (MMPs), as well as pro-inflammatory mediators, resulting in consequent skin damage and aging. To counteract this process, cosmetic industry is looking for compounds able to increase MMP inhibitory activities, hyaluronidase inhibitory activity, expression of collagen and elastase inhibitory activity, as potential bioactive ingredients with anti-aging purposes. This review focuses on skin aging factors and the potential anti-aging, anti-inflammatory, antimicrobial, anti-cellulite and anti-hair loss activity, as well as protection against UV damage, of coffee silverskin and their bioactive compounds.

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Section: Protection Against Skin Uv Damagementioning

confidence: 94%

Section: Protection Against Skin Uv Damagementioning

confidence: 99%

Coffee Silverskin: A Review on Potential Cosmetic Applications

2018

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“…Wang et al, 2019 investigated the anti-cancer effect of CGA and reported that CGAs have the ability to induce apoptotic cell death as well as inhibit cell proliferation 32 . CGAs have been reported to trigger apoptosis via inducing hydrogen peroxide production, stimulation of several caspases mainly caspase-3, besides activating mitochondria-dependent pathways 33,34 . Furthermore, caffeine may contribute to the induction of apoptosis in various cancer cell lines via several pathways 35,36 .…”

Section: Discussionmentioning

confidence: 99%

Assessment of Anti-Cancerous Effect of Green, Roasted and Decaffeinated Coffee on Oral Squamous Cell Carcinoma Cell Line (In Vitro Study)

Rashad

Latif

Abdul-Aziz

2021

JNR

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Oral Squamous Cell Carcinoma (OSCC) is one of the most prevailing malignancies of the head and neck area. So far, treatment methods are associated with harmful effects which drive attention towards natural compounds such as coffee. The current study attempted to test the anti-cancerous effect of green coffee, medium roasted coffee and decaffeinated coffee in OSCC cell lines and correlate the obtained results with their total phenolic content. We prepared coffee extracts using soxhlet apparatus. Then, we purchased and sub-cultured OSCC-25 cell into four study groups. We subjected three of those groups to coffee extracts separately. We left the remaining group without any treatment as a control group. We assessed cell cytotoxic effect of each extract by MTT viability assay. Additionally, we evaluated the apoptotic effect of each extract on OSCC-25 cell lines using flowcytometric analysis. Finally, we measured the total phenolic content in each coffee extract. The results revealed that coffee extracts induced varying degrees of cell cytotoxicity and apoptosis. Green coffee showed the highest cytotoxic and apoptotic effect followed by medium roasted coffee, then decaffeinated coffee. The total percentage of necrotic cells were higher in the coffee extracts groups, compared to the control group with a higher value in favor of green coffee followed by medium roasted coffee. Upon chemical analysis, the results showed that green coffee extract contained the highest concentration of phenolic compounds followed by medium roasted coffee then decaffeinated coffee extracts. We concluded that green coffee was the most potent anti-cancer extract. It seems plausible that coffee, and particularly green coffee could be for treating of OSCC.

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“…Since COX-2 and the associated PGs mediate uVB-induced cutaneous inflammation (5,35), these results indicate that 7-MEGA may exhibit an anti-inflammatory effect on UVB-irradiated human keratinocytes by downregulating coX-2. uVB induces the upregulation of MMP-1 and MMP-3 in skin cells and tissues (27,28,36), which causes UV-mediated skin inflammation and damage (7,37). a recent study has demonstrated the skin regenerative effects of 7-MeGa on H 2 o 2 -treated HacaT cells through the downregulation of MMP-1 and upregulation of type 1 procollagen (32).…”

Section: Discussionmentioning

confidence: 99%