Potential Effect of Carbimazole on Parotid Acini of Albino Rats

Abstract

Purpose: This study aimed to study the effect of carbimazole on parotid acini. Materials and Methods: 20 adult albino rats were selected and divided into two groups: control group (GI) consisted of 10 rats received distilled water by intragastric intubation for 6 weeks and carbimazole group (GII) in which 10 rats received carbimazole dissolved in distilled water with a dose (1.35mg/kg bodyweight/once/ day) by intra-gastric intubation for 6 weeks. Results: GI illustrated normal histological features of acini. Serous acini were apparently normal in size with pyramidal shaped cells with pyramidal shaped cells of apparently normal height surrounding narrow lumen with basally located nucleus and basophilic cytoplasm. Carbimazole group showed marked destruction in acini. Most of the acini were shrunken with consequent separation between the acini in some areas. Some acini showed apparent loss of cell height and apparent widening of their lumina. Statistical Results: GI showed higher mean area % of acini, compared to GII. The difference was statistically significant. Conclusion: carbimazole has destructive effect on parotid acini.

Histological and Immunohistochemical Study of Tartrazine Effect on The Adult Albino Rat Parotid Gland and The Possible Protective Role of Omega-3 Fatty Acids.

“…It was reported that reactive oxygen species attack the proteins and lipids that form the secretory granules membrane leading to its damage. In addition, they cause zymogen granules stability loss through an interaction with the protein contents and the nucleic acids of them (Hassan et al, 2021). Similar observations were demonstrated by Nasr El-Din &Abdel Fattah (2020) in hypothyroid rats and they were attributed to an increase in the Bax/Bcl-2 ratio.…”