Potential Dual Immunomodulatory Role of VEGF in Ulcerative Colitis and Colorectal Carcinoma

Zdravković, Nataša; Jovanović, Ivan; Radosavljević, Gordana; Arsenijević, Aleksandar; Zdravković, Nebojša; Mitrović, Slobodanka; Arsenijević, Nebojša

doi:10.7150/ijms.8277

Cited by 27 publications

(40 citation statements)

References 54 publications

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“…IL-6 and TGF-β direct the differentiation of naive Th lymphocytes towards the Th-17 phenotype [17–21]. We found higher values of IL-6 and IL-17/IL-10 ratio in patients with extra-intestinal manifestations of UC, while TGF-β values were unchanged, suggesting a key role of IL-6 in the development of the Th-17 immune response [10]. The increased expression of IL-17 in intestinal mucosa and its increased concentration in serum of patients with UC suggest that Th-17 cells play an important role in UC [10].…”

Section: Immunological Background Of Ibdmentioning

confidence: 99%

“…We found higher values of IL-6 and IL-17/IL-10 ratio in patients with extra-intestinal manifestations of UC, while TGF-β values were unchanged, suggesting a key role of IL-6 in the development of the Th-17 immune response [10]. The increased expression of IL-17 in intestinal mucosa and its increased concentration in serum of patients with UC suggest that Th-17 cells play an important role in UC [10]. Other study results show that the number of Th-17 cells and expressions of IL-17, IL-21 and IL-22 were significantly increased in intestinal tissue biopsies taken from patients with active UC and with active CD in comparison to healthy controls [22].…”

Section: Immunological Background Of Ibdmentioning

confidence: 99%

“…In our recent study, we have found significantly higher serum levels of both pro- and anti-inflammatory cytokines: TNF-α, TGF-β, IL-4, IL-6, IL-10, IFN-γ in patients with UC compared to healthy controls [10]. Analysis of the contra-regulatory cytokines ratio revealed significantly higher values of IFN-γ/IL-4, IFN-γ/TGF-β, IFN-γ/IL-10, IL-17/IL-10, IL-6/TGF-β, IL-27/IL-17, IL-17/TGF-β ratio in patients with UC compared to healthy controls, indicating pro-inflammatory cytokine predominance in patients with UC [10].…”

Section: Immunological Background Of Ibdmentioning

confidence: 99%

“…Analysis of the contra-regulatory cytokines ratio revealed significantly higher values of IFN-γ/IL-4, IFN-γ/TGF-β, IFN-γ/IL-10, IL-17/IL-10, IL-6/TGF-β, IL-27/IL-17, IL-17/TGF-β ratio in patients with UC compared to healthy controls, indicating pro-inflammatory cytokine predominance in patients with UC [10]. According to available data, the increased expression of pro-inflammatory cytokines, such as TNF-α, IL-1β and IL-6, and a deficiency of immunosuppressive IL-10 are hallmarks of intestinal inflammation [11–13].…”

Section: Immunological Background Of Ibdmentioning

confidence: 99%

“…Our previous results showed higher levels of IL-6 and CRP in sera of patients with UC and a correlation with the presence of extra-intestinal manifestations of disease [10]. In line with this finding, other study results showed that IL-6 was the predominant cytokine found in inflamed areas of UC patients and its concentration correlated with the Mayo endoscopic score for severity of the disease [10]. IL-6 is produced mainly by monocytes/macrophages and plays a major role in the development of the Th-17 immune response [17].…”

Section: Immunological Background Of Ibdmentioning

confidence: 99%

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The relationship between the immune system and oral manifestations of inflammatory bowel disease: a review

Vasovic¹,

Gajovic²,

Brajković³

et al. 2016

cejoi

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Inflammatory bowel diseases (IBDs) are chronic, relapsing inflammatory diseases characterized by exacerbations and remissions of the gastrointestinal tract, clinically manifested as Crohn’s disease and ulcerative colitis. The etiology of IBDs is considered to be multi factorial, comprising environmental, immune, microbial and genetic factors. Clinical signs may include abdominal pain, frequent bloody diarrheas, mucorrhea, vomiting, fever, fatigue or weight loss. Changes in the oral cavity often precede intestinal symptoms. Inflammatory bowel disease leads to a significant deterioration of oral health, which indicates that cooperation between the dentist and the gastroenterologist is necessary when considering patients’ welfare. Patients with IBD have an altered immune response, but microorganisms of the oral cavity may also be responsible for its modification.This review paper discusses the correlation between the immune system and inflammatory bowel disease manifestations in the oral cavity.

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Section: Immunological Background Of Ibdmentioning

confidence: 99%

Section: Immunological Background Of Ibdmentioning

confidence: 99%

Section: Immunological Background Of Ibdmentioning

confidence: 99%

Section: Immunological Background Of Ibdmentioning

confidence: 99%

Section: Immunological Background Of Ibdmentioning

confidence: 99%

See 3 more Smart Citations

The relationship between the immune system and oral manifestations of inflammatory bowel disease: a review

Vasovic¹,

Gajovic²,

Brajković³

et al. 2016

cejoi

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show abstract

Evolving Experimental Platforms to Evaluate Ulcerative Colitis

et al. 2022

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tissue thus altering tissue integrity, anatomy, and physiology subsequently affecting the overall health-related quality of life (HRQoL) of afflicted individuals. [1][2][3] It is estimated that the lifetime financial loss associated with the typical UC patient can be greater than $1 million/patient to cover direct and indirect medical expenses including treatment, hospitalizations, and general medical care. [3][4][5][6][7] As an example, vedolizumab and adalimumab treatment for UC had total direct medical costs of $100 022 and $151 133, respectively, per patient. [8] This number varies greatly depending upon the severity of the disease with a greater expense attributed to those exhibiting a poor clinical disposition. At the domestic level, the total cost to treat UC is estimated to be between $4-14 billion per year which seems to rise on an annual basis. [3,6,7] The specific etiological basis regarding the initiation and progression of UC is currently unknown. Physical manifestations of severe UC take the form of ulcerations affecting the mucosal lining, specifically along the length of the affected large intestine and rectum as depicted in Figure 1. These lesions contain an overabundant accumulation of innate and adaptive immune cells, including T cells, that promote an inflammatory environment Ulcerative colitis (UC) is a multifactorial disease defined by chronic intestinal inflammation with idiopathic origins. It has a predilection to affect the mucosal lining of the large intestines and rectum. Management of UC depends upon numerous factors that include disease pathogenesis and severity that are maintained via medical or surgical means. Chronic inflammation that is left untreated or managed poorly from a clinical stance can result in intestinal ulceration accompanied by resulting physiological dysfunction. End-stage UC is mediated by surgical intervention with the resection of diseased tissue. This can lead to numerous health-related quality of life issues but is considered a curative approach. Regimens to treat UC are ever evolving and find their basis within various platforms to evaluate and treat UC. Numerous modeling systems have been examined to delineate potential mechanisms of action. However, UC is a heterogenous disease spanning unknown genetic origins coupled with environmental factors that can influence disease outcomes and related treatment procedures. Unfortunately, there is no one-size-fits-all model to fully assess all facets of UC. Within the context of this review article, the utility of various approaches that have been employed to gain insight into different aspects of UC will be investigated.

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Mdm4

Salajegheh¹

2016

Angiogenesis in Health, Disease and Malignancy

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Potential Dual Immunomodulatory Role of VEGF in Ulcerative Colitis and Colorectal Carcinoma

Cited by 27 publications

References 54 publications

The relationship between the immune system and oral manifestations of inflammatory bowel disease: a review

The relationship between the immune system and oral manifestations of inflammatory bowel disease: a review

Evolving Experimental Platforms to Evaluate Ulcerative Colitis

Mdm4

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