The relationship between the immune system and oral manifestations of inflammatory bowel disease: a review

Vasovic, Miroslav; Gajovic, Nevena; Brajković, Denis; Jovanović, Marina; Zdravkovaic, Natasa; Kanjevac, Tatjana

doi:10.5114/ceji.2016.63131

Cited by 37 publications

(34 citation statements)

References 98 publications

(145 reference statements)

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“…In fish, the stimulation of different cytokines including tlr-5, il-1β, nf-κb, and il-8 played important roles in intestinal defense and inflammation. The innate immune mechanism of protecting the host from pathogens is related to the alteration of normal endogenous microbiota [78,79]. In this study, long-term exposure to DEHP potentially evoked the expressions of genes related to the immune response in male intestines in the low concentration groups (10-33 µg/L), but significantly inhibited the mRNA level of tlr-5 and il-1β genes in female zebrafish, especially in the highest-level group (100 µg/L).…”

Section: Discussionmentioning

confidence: 99%

DEHP chronic exposure disturbs the gut microbial community and metabolic homeostasis: Gender-based differences in zebrafish

Pei

Jia

Xin

et al. 2020

Preprint

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Background: Di-(2-ethylhexyl) phthalate (DEHP), a predominant phthalate ester (PAE), exhibits various toxic potentials with environmental and human health risks. However, the chronic effects of DEHP exposure on gut microbiota and associated host’s health are still largely unexplored. Here, zebrafish were exposed to relative environmental levels (0-100 μg/L) of DEHP from embryos to adult (3.5 months), then the developmental indexes and microbiota as well as the related energy metabolites in gut tissues were checked to unveil the effects during the growth progress. Results: The results indicated that the composition of gut microbiota was different among male and female adult zebrafish, and DEHP disrupted the diversity and richness of the bacterial community. The histopathological analysis of intestinal tissues revealed the decrease of villus length and tunica muscularis thickness, especially the goblet cells per villi in male fish. Moreover, energy metabolites in gut tissues were actively increased at lower levels groups, which probably contribute to the condition factor of host. For immune-related genes, the expression levels of il-8 was increased both in female and male fish in the lowest concentration (10 μg/L), but the tlr-5 and il-1β genes were in the different response with significantly decreased in female fish. Conclusion: Taken all together, those results indicated that chronic exposure to DEHP led to zebrafish obesity with the disturbed bacterial community in the gut and related metabolism pathways. Those findings provided deep insights on the perturbation of gut microbiota, metabolic homeostasis, and gender-based differences by DEHP exposure.

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Section: Discussionmentioning

confidence: 99%

DEHP chronic exposure disturbs the gut microbial community and metabolic homeostasis: Gender-based differences in zebrafish

Pei

Jia

Xin

et al. 2020

Preprint

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“…This result possibly explains the inflammation scores and decreased histological features of the NFXi group. Notably, IL-10 is an influential interleukin that can modulate pro-and anti-inflammatory cytokines 38 , and IL-10 can also suppress exacerbated mucosal immune responses, maintain intestinal homeostasis and tolerance to commensal microbiota 39 and inhibit collagen deposition in the host intestine 30 .…”

Section: Discussionmentioning

confidence: 99%

Mycobacterial Hsp65 antigen delivered by invasive Lactococcus lactis reduces intestinal inflammation and fibrosis in TNBS-induced chronic colitis model

Cunha

Preisser

Santana

et al. 2020

Sci Rep

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Intestinal fibrosis associated with Crohn’s disease (CD), which a common and serious complication of inflammatory bowel diseases. In this context, heat shock proteins (HSPs) might serve as an alternative treatment because these antigens play important roles in the regulation of effector T cells. We thus evaluated the anti-inflammatory and antifibrotic capacities of an invasive and Hsp65-producing strain—Lactococcus lactis NCDO2118 FnBPA+ (pXYCYT:Hsp65)—in chronic intestinal inflammation to assess its potential as an alternative therapeutic strategy against fibrotic CD. Experimental colitis was induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) in BALB/c mice, and the mice were treated orally with L. lactis NCDO2118 FnBPA+ (pXYCYT:Hsp65) via intragastric gavage. The oral administration of this strain significantly attenuated the severity of inflammation and intestinal fibrosis in mice (p < 0.05). These results are mainly justified by reductions in the levels of the pro-fibrotic cytokines IL-13 and TGF-β and increases in the concentration of the regulatory cytokine IL-10. The L. lactis NCDO2118 FnBPA+ (pXYCYT:Hsp65) strain contributed to reductions in the severity of inflammatory damage in chronic experimental CD, and these findings confirm the effectiveness of this new antifibrotic strategy based on the delivery of therapeutic proteins to inside cells of the host intestinal mucosa.

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“…In fact, VD deficiency has been reported in 60% of patients with inflammatory bowel disease [7]. This vitamin also plays a role in intestinal health mainly by resisting infection and regulating the immune response, including maintaining the balance of intestinal flora and the barrier function of the intestinal epithelium [8].…”

Section: Introductionmentioning

confidence: 99%

No association of vitamin D binding protein gene polymorphisms with ulcerative colitis in Chinese patients

Qiu

Zhang

Wang

et al. 2019

Preprint

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Object Vitamin D (VD) deficiency has been reported in patients with ulcerative colitis (UC), and polymorphism in the gene encoding the vitamin D binding protein (DBP) can affect the characteristics of DBP, thus affecting the level and function of VD in vivo . Previous studies have rarely reported on the potential relationship between DBP polymorphisms and UC. To investigate the associations between genetic variants in DBP genes and UC susceptibility in the Han Chinese population, in order to discern whether any differences exist between this population and those of other countries.Methods In this case-control study, the genotyping of DBP rs4588 and rs7041 polymorphisms was conducted using polymerase chain reaction (PCR)-ligase detection reactions, and the rs4588 and rs7041 genotypes were detected by PCR-restriction fragment length polymorphism.Results In our case-control cohort, no significant difference was observed in the UC risk for either of the two SNPs (rs4588 and rs7401) in the DBP genes ( P > 0.05). No association between UC susceptibility and the DBP gene haplotypes was found either.Conclusions Our results suggest that the two SNPs (rs4588 and rs7401) in the DBP genes may have no correlation with susceptibility to UC in the Chinese Han population. But interestingly, haplotype GC, which contains the rs4588 and rs7041 variants in the DBP gene, may affect the level of oxidative stress in UC patients, especially the level of MDA.

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The relationship between the immune system and oral manifestations of inflammatory bowel disease: a review

Cited by 37 publications

References 98 publications

DEHP chronic exposure disturbs the gut microbial community and metabolic homeostasis: Gender-based differences in zebrafish

DEHP chronic exposure disturbs the gut microbial community and metabolic homeostasis: Gender-based differences in zebrafish

Mycobacterial Hsp65 antigen delivered by invasive Lactococcus lactis reduces intestinal inflammation and fibrosis in TNBS-induced chronic colitis model

No association of vitamin D binding protein gene polymorphisms with ulcerative colitis in Chinese patients

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