Potential Determinants of Coal Workers’ Pneumoconiosis, Advanced Pneumoconiosis, and Progressive Massive Fibrosis Among Underground Coal Miners in the United States, 2005–2009

Laney, A. Scott; Petsonk, Edward L.; Hale, Janet M.; Wolfe, Anita L.; Attfield, Michael D.

doi:10.2105/ajph.2011.300427

Cited by 46 publications

(37 citation statements)

References 8 publications

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“…Exposure to respirable crystalline silica dusts is very common in a multitude of industries and occupational settings. Inhalation of fine silica, including their most abundant naturally occurring polymorphs quartz and cristobalite, can lead to progressive pulmonary fibrosis and silicosis which continues to be a problem in developed and in third world countries [ 1 ]. The presence and severity of the disease depends on many factors such as individual susceptibility, and the level and duration of exposure [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

et al. 2014

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RationaleMineral particles in the lung cause inflammation and silicosis. In myeloid and bronchial epithelial cells the inflammasome plays a role in responses to crystalline silica. Thioredoxin (TRX) and its inhibitory protein TRX-interacting protein link oxidative stress with inflammasome activation. We investigated inflammasome activation by crystalline silica polymorphs and modulation by TRX in vitro, as well as its localization and the importance of silica surface reactivity in rats.MethodsWe exposed bronchial epithelial cells and differentiated macrophages to silica polymorphs quartz and cristobalite and measured caspase-1 activity as well as the release of IL-1β, bFGF and HMGB1; including after TRX overexpression or treatment with recombinant TRX. Rats were intratracheally instilled with vehicle control, Dörentruper quartz (DQ12) or DQ12 coated with polyvinylpyridine N-oxide. At days 3, 7, 28, 90, 180 and 360 five animals per treatment group were sacrificed. Hallmarks of silicosis were assessed with Haematoxylin-eosin and Sirius Red stainings. Caspase-1 activity in the bronchoalveolar lavage and caspase-1 and IL-1β localization in lung tissue were determined using Western blot and immunohistochemistry (IHC).ResultsSilica polymorphs triggered secretion of IL-1β, bFGF and HMGB1 in a surface reactivity dependent manner. Inflammasome readouts linked with caspase-1 enzymatic activity were attenuated by TRX overexpression or treatment. At day 3 and 7 increased caspase-1 activity was detected in BALF of the DQ12 group and increased levels of caspase-1 and IL-1β were observed with IHC in the DQ12 group compared to controls. DQ12 exposure revealed silicotic nodules at 180 and 360 days. Particle surface modification markedly attenuated the grade of inflammation and lymphocyte influx and attenuated the level of inflammasome activation, indicating that the development of silicosis and inflammasome activation is determined by crystalline silica surface reactivity.ConclusionOur novel data indicate the pivotal role of surface reactivity of crystalline silica to activate the inflammasome in cultures of both epithelial cells and macrophages. Inhibitory capacity of the antioxidant TRX to inflammasome activation was evidenced. DQ12 quartz exposure induced acute and chronic functional activation of the inflammasome in the heterogeneous cell populations of the lung in associated with its crystalline surface reactivity.Electronic supplementary materialThe online version of this article (doi:10.1186/s12989-014-0058-0) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

et al. 2014

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“…19 Further study is important given that the central Appalachian coal fields have been identified as an area with significant rates of rapidly progressive and advanced disease. 6,7,25–27 …”

Section: Discussionmentioning

confidence: 99%

Linking Compensation and Health Surveillance Data Sets to Improve Knowledge of US Coal Miners’ Health

Almberg

Cohen

Blackley

et al. 2017

Journal of Occupational &Amp; Environmental Medicine

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Objective Increase knowledge of US coal miners’ respiratory health by linking data from the black lung benefits program (BLBP) and the coal workers’ health surveillance program (CWHSP). Methods BLBP claims data from 2000 through 2013 was linked to CWHSP data from 1970 through 2016. Results Overall, 273,644 miners participated in CWHSP, 37,548 in BLBP, and 22,903 in both programs. Median age of miners at their time of first/only participation in CWHSP was 28 and 32 years, respectively. BLBP claimants were older (median age 59). Thirty-nine percent of BLBP claimants had not participated in CWHSP. The relative contributions of states to participation differed between CWHSP and BLBP. For example, Kentucky miners accounted for 18% of CWHSP participants, but 36% of BLPB participants. Conclusions Many BLBP claimants never appeared in CWHSP, indicating missed opportunities for secondary prevention.

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“…The average age of death due to pneumoconiosis significantly decreased from 2011 to 2012 in Kentucky then remained the same in 2013. This result may suggest that workers are being diagnosed with severe forms of pneumoconiosis at younger ages, and young miners with less mining tenure may be at heightened risk for the development of pneumoconiosis [Laney et al, ].…”

Section: Discussionmentioning

confidence: 99%

“…There has not only been an increase in prevalence, but also in the severity of pneumoconiosis for younger miners with less cumulative exposure. In a study done on underground coal miners from 2005 to 2009, when compared to 12 other states, miners in Kentucky, Virginia, and West Virginia, had a greater risk of advanced CWP (RR = 8.1), progressive massive fibrosis (RR = 10.5), and r‐type opacities(RR = 7.7), in younger miners with less mining tenure [Laney et al, ].…”

Section: Introductionmentioning

confidence: 99%

Patterns of pneumoconiosis mortality in Kentucky: Analysis of death certificate data

Beggs

Slavova

Bunn

2015

American J Industrial Med

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Potential Determinants of Coal Workers’ Pneumoconiosis, Advanced Pneumoconiosis, and Progressive Massive Fibrosis Among Underground Coal Miners in the United States, 2005–2009

Abstract: Enhanced surveillance results confirmed the persistence of severe CWP among US coal miners and documented the health consequences of inadequate dust control for miners in parts of Appalachia and at smaller mines.

Cited by 46 publications

References 8 publications

Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

Linking Compensation and Health Surveillance Data Sets to Improve Knowledge of US Coal Miners’ Health

Patterns of pneumoconiosis mortality in Kentucky: Analysis of death certificate data

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