Potential Curative Effect of Curcumin on Gastric Ulcer Induced by Piroxicam in Male Albino Rats

Abstract

This study intended to investigate the curative effect of curcumin on piroxicam-induced gastric ulcer in rats. Twenty-seven male albino rats were allocated into three similar groups (9 of each). The first group (G1) was the control, G2 received piroxicam (30 mg∕ kg BW.) to induce gastric ulcer and G3 received piroxicam (30 mg∕ kg BW.) and on the third day it received curcumin (200 mg ∕ kg BW.) orally for 21 day. At the end of the experiment, the rats were humanly euthazied and blood and serum samples were taken for haematological and biochemical analysis, respectively. Subsequently, the stomachs were opened along their curvature for evaluation of ulceration, gastric juice was measured and gastric samples were preserved in 10% neutral buffered formalin for histopathological examination. Piroxicam administration induced gastric ulceration (100%), non-significant changes in the gastric juice volume and a remarkable decrease in the number of red blood cells, hemoglobin concentration and packed cell volume with a significant increase in platelets count, white blood cells, neutrophils, eosinophils and monocytes. Furthermore, it displayed a significant reduction of glutathione peroxidase, superoxide dismutase and catalase activities with a significant increase in malondialdehyde and tumor necrosis factor alpha concentrations. Histopathological results revealed focal mucosal erosive and ulcerative changes with sever hyperemia of stomach in piroxicam treated group (G2). Oral administration of curcumin treated the piroxicam induced gastric ulceration and improved the altered hematological parameters, oxidant ∕ antioxidant status and histological pictures of rats in G3. Therefore, curcumin may offer an attractive strategy for treatment of gastric ulcer.

Therapeutic Effects of Esomeprazole, Curcumin, Chitosan, and Curcumin-Chitosan Mixture on Ethanol-Induced Gastric Ulcer in Female Rats

“…We can link these results with other studies, the role of Bryophyllum pinnatum leaf extract in healing acetic acid-induced chronic GU model in rats (Araugo et al, 2021) All study groups showed non-significant differences in the volume of gastric juice, which was still within the normal range compared to the normal control group. This result is in agreement with Ibrahim et al (2019), who revealed that the piroxicam-induced ulcer model in rats showed non-significant changes in the gastric juice volume.…”

Anti-ulcer and gastro protective effects of dexlansoprazole in experimentally induced gastric ulcer in rats

“…As presented in Table 4, piroxicam treatment triggered a significant rise in hepatic and renal serum biomarkers, such as creatinine, urea, uric acid, ALT, AST, and Alkaline phosphatase levels, in comparison to controls (P≤0.05). These findings were consistent with earlier researches [46][47][48] that indicated that piroxicam caused significant rise in markers of liver and kidney activity, lowered PG-E2 concentrations and stimulated oxidative stress.…”