Potential Causal Association between Depression and Oral Diseases: A Mendelian Randomization Study

Zhang, Xiaobin; Jiang, Hehe; Zhang, Linlin; Li, Chunjing; Chen, Chen; Xing, Mengzhen; Ma, Yuning; Ma, Yuxia

doi:10.3390/genes14122191

Cited by 3 publications

(1 citation statement)

References 70 publications

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“…Depression is a common disease of mood disorder that is characterized by constant melancholy, cognitive injury, and lack of interest. Severe depression often leads to thoughts about death, accompanied by self-abuse and even suicidal tendencies [ 1 ]. Depression influences many individuals, with more than 300 million individuals diagnosed with the disease each year [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic Causal Associations between Various Serum Minerals and Risk of Depression: A Mendelian Randomization Study

Wang,

Liu,

Yang

2024

Actas Esp Psiquiatr

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Background: Previous observational studies have discovered a connection between depression and mineral status. Confirming this potential connection is challenging due to confounding factors and potential reverse causality which is inherent in observational studies. Materials and Methods: We performed a Mendelian randomization (MR) analysis to estimate the causal association of serum minerals with depression. Leveraging summary-level data on depression, a genome-wide association study (GWAS) was applied. The data on serum minerals were collected from the FinnGen Biobank database. MR assessments representing causality were produced by inverse-variance weighted approaches with multiplicative random and fixed effects. Result: Sensitivity analyses were performed to validate the reliability of the results. A noteworthy correlation emerged between serum zinc levels and reduced risk of depression. An odds ratio (OR) of 0.917 for depression associated with a one standard deviation increase in serum zinc levels (OR = 0.968; 95% CI = 0.953–0.984, p = 1.19 × 10-4, random effects model inverse variance weighted (IVW)); (OR = 0.928; 95% CI = 0.634–1.358, p = 0.766, MR Egger). Sensitivity assessments supported this causation. However, the risk of depression did not exhibit an association with other minerals. Conclusions: In summary, a higher zinc concentration is causally associated with a reduced depression risk. This MR outcome may assist clinicians in the regulation of specific mineral intake, particularly for high-risk patients with serum zinc deficiencies.

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Section: Introductionmentioning

confidence: 99%

Genetic Causal Associations between Various Serum Minerals and Risk of Depression: A Mendelian Randomization Study

Wang,

Liu,

Yang

2024

Actas Esp Psiquiatr

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Mendelian randomization studies of periodontitis: Understanding benefits and natural limitations in an applied context

Haworth,

Timpson,

Divaris

2024

J Clinic Periodontology

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Mendelian randomization (MR) is a flexible analytical tool that has been widely applied to strengthen causal inference in observational epidemiology and is now gaining attention in many areas including periodontal research. The interpretation of results drawn from MR is based on a series of assumptions, which can be unrealistic or difficult to meet faithfully in some settings. However, we argue that with care, this does not necessarily prevent valuable deployment of the approach. We argue that clarity of presentation as well as careful assessment of specific analytical conditions is a fundamental part of all MR analyses. To that end, awareness of its limitations should also guide the design of MR investigations and the presentation of results rather than rule out its use altogether. Notably, considerations similar to those known to be important in conventional epidemiological settings apply to MR. While MR studies are valuable in their contrast to other study limitations, the application of this technique must be carefully cross‐examined. Specific considerations include possible confounders, recruitment strategy and phenotypic measurement and differential analysis properties across studies. In the case of periodontal research, current MR applications are limited by the available evidence base for genetic contributions to periodontitis; however, this sets a specific scene for the strategic use of MR and shines light on a need for greater research emphasis on the genetics of the condition and intermediaries. This article provides a perspective on the uses and inherent limitations of MR studies and the importance of adhering to basic epidemiological principles when designing them.

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Clinical research progress on acupuncture for the treatment of otogenic vertigo

Yi,

Yang,

Wang

et al. 2024

World J Clin Cases

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Otogenic vertigo is a common disorder that affects the vestibular system, which often results in considerable discomfort and impaired daily functioning. Traditional Chinese medicine (TCM), including acupuncture and moxibustion, has been historically utilized to manage the symptoms of vertigo. However, the effectiveness and methodology of these treatments have rarely been investigated in the medical literature. This study reviews the existing literature on the point selection, method, and therapeutic effect of acupuncture and moxibustion to provide a reference for the TCM treatment of otogenic vertigo. A literature search was performed using the PubMed search engine. The terms used included otogenic vertigo, acupuncture treatment, and acupuncture point selection. A total of 34 relevant articles were retrieved from PubMed. These suggest that the clinical treatment of otogenic vertigo should consider the functions of zang-fu organs and meridians and select different acupuncture treatment methods according to syndrome differentiation based on the difference between deficiency and excess. Acupuncture and moxibustion therapy should be based on acupoint selection, considering the syndrome differentiation, supplemented with experience. The treatment of otogenic vertigo with acupuncture and moxibustion refers to the selection of appropriate acupuncture methods under the guidance of TCM theory and following the principles of syndrome, disease, and meridian differentiation. Common acupuncture methods include body acupuncture, auricular acupuncture, scalp acupuncture, acupoint injection, electroacupuncture, and moxibustion. There are many acupuncture and moxibustion acupoints selected for the treatment of otogenic vertigo. Individualized treatment according to the patient’s specific condition is effective and safe, which can help to improve the patient’s vertigo symptoms and cerebral blood perfusion.

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Potential Causal Association between Depression and Oral Diseases: A Mendelian Randomization Study

Cited by 3 publications

References 70 publications

Genetic Causal Associations between Various Serum Minerals and Risk of Depression: A Mendelian Randomization Study

Genetic Causal Associations between Various Serum Minerals and Risk of Depression: A Mendelian Randomization Study

Mendelian randomization studies of periodontitis: Understanding benefits and natural limitations in an applied context

Clinical research progress on acupuncture for the treatment of otogenic vertigo

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