Mendelian randomization studies of periodontitis: Understanding benefits and natural limitations in an applied context
Simon Haworth,
Nicholas J. Timpson,
Kimon Divaris
Abstract:Mendelian randomization (MR) is a flexible analytical tool that has been widely applied to strengthen causal inference in observational epidemiology and is now gaining attention in many areas including periodontal research. The interpretation of results drawn from MR is based on a series of assumptions, which can be unrealistic or difficult to meet faithfully in some settings. However, we argue that with care, this does not necessarily prevent valuable deployment of the approach. We argue that clarity of prese… Show more
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